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The supplement Methyldrene EPH by Cloma Pharma constitutes an incredibly strong pre-workout supplement, which will ensure high energy level and motivation for training. Many active substances are responsible for its effectiveness. They cause not only strong stimulation of muscle work, but they also decrease the feeling of fatigue and positively regulate the work of the nervous system.
Creatine monohydrate - creatine is an important peptide, which naturally occurs in the organism. It is synthesized from 3 amino acids: arginine, glycine and methionine and its main storehouse is muscle tissue. In its cells, facilitation of energy synthesis takes place, which effectively contributes to the improvement of training efficiency.
The mechanism of activity of creatine consists in the fact that after reaching the inside of cells, it binds phosphate groups produced after ATP breakdown. Thanks to this, a molecule of phosphocreatine is produced, which moves these high-energy groups to ADP molecules, thanks to which resynthesis of ATP is stimulated. This process ensures high level of short-lasting energy during training.
The occurrence of the active molecule in the form of monohydrate also ensures high hydration of muscle cells. It contributes to increasing their mass and size, which provides the feeling of muscle pump. Additionally, water constitutes ideal environment for the processes taking place inside a cell, e.g. the synthesis of new muscle proteins, energy production.
Increased creatine level in muscles also demonstrates ergogenic effect. It results from the fact that the active substance protects glycogen from excessively fast utilization. It reduces the level of lactate produced during the process of oxidation, which weakens the effectiveness of muscle work as the training progresses.
Citrulline and arginine - active amino acids engaged in the synthesis of nitric oxide and elimination of redundant metabolic products in the organism. Both these processes ensure changes in the organism, which contribute to improving the effectiveness of its work. These amino acids demonstrate a synergistic effect, therefore their supplementation allows to achieve maximal effects related to them. Citrulline after reaching the organism is converted in the kidneys to arginine.
In the course of basic metabolic changes, by-products are produced in the organism, which include i.a. ammonia. As the concentration of this substance increases, many processes are deteriorated, e.g. muscle work. The organism protects itself from this compound by carrying out the ornithine cycle. Both citrulline and arginine take part in this cycle and lead to transforming ammonia in urea. Thanks to this, redundant nitrogen compounds are eliminated from the organism, which contributes to its effective work.
Both these substances take active part in the synthesis of nitric oxide. During the conversion of arginine to citrulline, NO molecule is secreted. The increase its concentration in smooth muscles of blood vessels leads to a cascade of events, which stimulates widening their lumen. It allows to achieve maximal muscle pump. It ensures better oxygenation of muscle tissue and its nourishment, which is reflected in its effective work.
Arginine alpha-ketoglutarate (AAKG) - a molecule, which is built of glutaric acid salt and arginine in the proportion 1:2. Binding this organic compound with an amino acid ensures its better activity and high stability. It allows to facilitate the synthesis of nitric oxide in the organism, which contributes to the improvement of training performance.
Alpha-ketoglutarate is a molecule taking active part in Krebs cycle. Thanks to this, it also facilitates the process of energy synthesis in the organism.
Caffeine - is one of the most popular stimulants used by sportsmen. After reaching the organism, it ensures production increase of catecholamines - adrenaline and noradrenaline. It results from the fact that caffeine inhibits the activity of an enzyme - catechol-O-methyltransferase, which causes their breakdown in the synapses. This results it stronger reuptake of hormones, which considerably prolongs their activity.
These hormones cause stimulation of the sympathetic system, which is engaged in the process of energy production and strong motivation to train.
Thanks to its lipophilic structure, caffeine effectively permeates blood-brain barrier. It ensures efficient production of dopamine, acetylcholine and serotonin in the nervous system. These compounds are responsible for improving concentration, cognitive functions and motivation to act.
Moreover, the active substance has inhibiting effect on adenosine receptors. Their activation causes inhibition of the production of catecholamines and other stimulating neurotransmitters. Inhibiting its activity contributes to larger psychophysical stimulation of the organism.
DMAE - is a molecule, the whole name of which is dimethylethanolamine. It constitutes an important precursor of acetylcholine, thanks to which it facilitates its synthesis in the organism. Such an effect ensures high motivation to train.
The active substance also reduces the level of beta-amyloid, which disturbs the work of the nervous system and cognitive functions.
Powdered Ephedra Viridis leaf - this plant, contrary to its other variations, does not contain ephedrine, which is a banned substance. The extract from this plant, however, contains tannins and other alkaloids, which ensure strong stimulation of the organism.
Active substances also influence proper centers in the nervous system, thanks to which they cause acceleration of metabolism and appetite reduction. These effects are especially vital during reducing fatty tissue.
Leucin - is one of amino acids which are the components of BCAA. They are characterized by the presence of the side chain in a molecule. During long-lasting workouts, when the level of glycogen is depleted, the organism obtains energy from branched-chain amino acids contained in muscle tissue. It not only causes the intensification of catabolic processes, but also higher tryptophan release, which in the nervous system stimulates the synthesis of serotonin. Sudden increase of the level of this neurotransmitter is responsible for strong fatigue. Using leucin helps to maintain proper level of tryptophan, which prevents the accumulation of fatigue during workout.
Moreover, leucin reduces the level of nitric compounds, which are produced during exercises. They cause negative changes in the work of the organism, which also result in higher fatigue.
The application of proper amounts of leucin is also important in relation to the synthesis of proteins. This amino acid activates mTOR kinase, which is directly engaged in this process.
Yohimbe extract - bark from this tree is characterized by the content of alkaloid, named yohimbine. This substance stimulates the secretion of catecholamines in the organism, thanks to which it ensures high energy level. It is related to stronger activation of the sympathetic nervous system of the organism.
Moreover, this substance supports fat burning and the synthesis of new adipose cells. It is related to its inhibiting effect on the work of α2-adrenergic receptors.
The increase of the level of adrenaline in the nervous system helps to effectively reduce appetite and its stimulating influence protects from the drop of energy during tough training in the period of weight loss.
Alpha-GPC – a molecule belonging to the compounds from the group of phospholipids, which contains choline. The active substance ensures high level of energy and improves cognitive functions of sportsmen.
The fact that choline constitutes a precursor for the synthesis of acetylcholine is responsible for the positive effect of alpha-GPC. The increase of the level of this neurotransmitter in the nervous system is related to the improvement of cognitive functions and better work of muscles.
Stronger stimulation of movement neurons by acetylcholine allows to improve effectiveness of work of the organism during tough training sessions. This neurotransmitter also stimulates the secretion of adrenaline and noradrenaline.
cAMP - also called cyclic adenosine monophosphate. It is a substance belonging to the group of nucleotides, which naturally appears in the organism. It plays the role of one of the main mediators of signal transmission in the organism.
The increase of the level of cAMP inside a cell leads to the higher secretion of adrenaline and noradrenaline in the organism. These neurotransmitters cause switching the organism from the rest mode to the state of fight, which results in its more effective work. It allows to achieve high stimulation and perform effective training.
Powdered fruit of Schisandrae Chinensis - a fruit from this plant demonstrates ergogenic and adaptogenic effects. Lignans and triterpenoids contained in the material stimulate the synthesis of dopamine in the nervous system, which contributes to achieving better concentration and motivation during training.
To sum up, Cloma Pharma Methyldrene EPH is a dietary supplement, which by means of many mechanisms ensures strong stimulation of the organism, especially during tough period of reduction. The substances contained in the preparation stimulate many processes in the organism, which are engaged in energy production, achieving strong muscle pump and motivation to train.
The product is recommended to advanced sportsmen, who care about strong stimulation. Moreover, it constitutes a fantastic solution for people who are trying to lose weight, as it intensifies this process and protects from the drop of energy.
When using it for the first time, we absolutely recommend to use only one portion in order to see the body's tolerance to it. It's a potent product, and for some individuals it may be too strong. Then we recommend a dose reduction to 0,5 or 2/3 scoops. Do not take the supplement in the evening and up to several hours before bedtime.
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|per portion (6 g)||amount||%DV|
|Creatine Monohydrate||1199 mg||*|
|L-Cytruline Malate||800 mg||*|
|L-Arginine Alpha-Ketoglutarate (AAKG)||639 mg||*|
|L-Arginine Malate||600 mg||*|
|Caffeine Anhydrous||160 mg||*|
|Dimethylaminoethanol (DMAE) bitartrate||30 mg||*|
|Ephedra Viridis Powder (leaves)||25 mg||*|
|Yohimbe Extract 8% Yohimbine||12,5 mg||*|
|L-Alphaglycerylphosphorylcholine (Alpha-GPC)||0,02 mg||*|
|Cyclic adenosine monophosphate (cAMP)||0,01 mg||*|
|Fructus Schisandrae Chinensis (Schisandra Berry) Powder||0,001 mg||*|
Natural Citrus Flavor, Citric Acid, Sucralose, Silicon Dioxide, FD&C Yellow #5, and FD&C Red#40.
Creatine monohydrate is a popular and cheapest form of creatine used in sports supplementation in Poland. This is a molecule, in which are bound: creatine molecule with a molecule of water. It has a high bioavailability and tissue velocity saturation. Supports the exercise capacity (strength and endurance), accelerates muscle growth and regeneration after training exercise. Transport of creatine into the muscle cells is supported by the insulin hormone. For better effect of saturation of the tissues, a diet increasing the content of insulin in the body is indicated (carbohydrate and high protein diet) and supporting nutrients and supplements (Dietary carbohydrate and carbohydrate-protein, insulin ALA, d-pinitol or taurine). Creatine monohydrate is present in the form of mono-preparation supplements (capsules, powders, tablets) and multicomponent supplements (i.e. as a component of creatine stacks).
Dosage: depending on the form of supplement, the type of exercise and weight, normally are used one of the following models of creatine supplementation:
- cyclic supplementation : 5-10g per day in 1-3 portions during the day, 3-5g per dose. The length of the cycle for 4-8 weeks.
- cyclic supplementation with saturated phase: the first 5-7 days after 20-30g daily in 4-6 doses of 4-6g per serving, then the maintenance phase 2-10g per day in divided doses. The length of the cycle 4-8 weeks
- constant supplementation: 0,03-0,05g per kg of body weight for an extended period of time.
Arginine alpha-ketoglutarate (AAKG) is a salt glutaric acid and arginine. The presence of these compounds results in intensification of the operation of each of them. Arginine alpha-ketoglutarate improves the bioavailability by stimulating the decomposition to CO2 and H2O, which means that it becomes a precursor in the synthesis of nitric oxide. It has anti-catabolic properties enhancing anabolism. Enhances the functioning of the insulin hormone, insulin-mimetics IGF-1) and somatotropin growth hormone.
AAKG is part of the pre-workout supplements (improving muscle blood flow and increasing the exercise capacity (strength and endurance)), as well as improves the recovery process after training. Most often used to increase the synthesis of nitric oxide (supplements pre- and post-workout), increasing muscle blood flow and regeneration. Particularly valued by the representatives of power sports, power and strength sports and strength athletics. Used very often in the rehabilitation of sports injuries.
Arginine is an exogenous amino acid, it is a component of dietary proteins, not always synthesized in the human body in necessary quantity, so it is necessary to deliver it in the form of synthetics. It takes part in the biosynthesis agmatine, creatine and nitrogen oxides. The use of supplements containing arginine before workout increases the exercise capacity (strength, endurance). Used after considerable effort intensifies the transfer of energy and building compounds and intensifies the process of recovery. Used at bedtime in combination with lysine and ornithine enhances the synthesis of growth hormone. takes part in the intrasystemic synthesis of creatine. Arginine (as a precursor of ornithine) is involved in the urea cycle, increases the flow of blood in the circulatory system, increases sexual potency (in a short time after application). It affects the body's immunity preventing infections, and lowers blood pressure. In supplements – usually as alpha-ketoglutarate.
Caffeine (1,3,7-trimethylxanthine, 1-methylotheobromine) is a purine alkaloid occurring in the natural state in plants (Coffea arabica, Camelia sinensis, Paulinia cupana, Ilex paraguariensis), which acts as a natural pesticide, acting toxic to insects. Peculiar smell and taste also deters herbivores. Caffeine in the body inhibits the adenosine receptors in the brain, fighting fatigue and allowing for action activation. It has a beneficial effect on the metabolism of oxygen, which increases the exercise capacity (strength and endurance) and rapid post-workout recovery. In the sports supplementation, caffeine is used as a stimulant nervous system. It has the thermogenic potential and in combination with other substances (e.g. Polyphenols, both occurring in coffee beans, such as cocoa beans, tea leaves and mate) can effectively participate in the reduction of body fat. It is included in many dietary stimulants (creatine stacks, no-boosters, beverages). It is a component of fat burners. It is also in the form of mono-preparation supplements.
Dosage: 100-600 mg per day. Due to the long release of activity should not be used in the evening, before sleep.
Ephedra Viridis – a plant known also as green Mormon tea or Green ephedra, gaining popularity since banning its relative Ephedra sinica by FDA. It contains alkaloids with thermogenic properties and thus increases the body’s energy expenditure, thereby creating a larger calorie deficit. It is therefore an effective way to speed up fat burning. Because of its activity, Ephedra viridis extracts are a frequent additive to fat burners.
Some sources report that supplementation with Green ephedra curbs the appetite. It helps stick to a diet, especially during low calorie intake.
In addition, it is that Ephedra viridid is a source of flavonoids capable of reducing the amount of free radicals in the body. Owing to that, supplements with this plant extract reduce oxidative stress, thereby promoting health.
Leucine is an essential amino acid, one of the three branched chain amino acids, ketogenic, its isomer is isoleucine. It affects the secretion of anabolic hormones (insulin, combined carbohydrates), acts on enzymes (mTOR) starting the process of muscle protein synthesis and controlling its course. Protein synthesis by leucine is affecting the development of bones, muscles and skin. It reduces the fat tissue. Without the availability of leucine, protein synthesis is impossible. It naturally occurs in animal products (such as eggs, meat, dairy and fish), plant origin, and as a post-training supplements, BCAA, EAA, no-boosters, creatine stacks, carbohydrate supplements. Ir is also in the form of mono-preparation supplements. It is one of the most important amino acids for the athlete's body, basically in every sports discipline.
Dosage: The demand is 5-10 g / 24h, dosage pre- and post-workout and in the morning after waking up.
Yohimbine is a natural component of the indole alkaloid yohimbine, ingredient of bark of yohimbe (Corynanthe yohimbe), a recognized aphrodisiac and increasing potency mean. It stimulates the nervous system by blocking the adrenergic receptors alpha-2. Tree bark of yohimbe is also a source of alkaloids (isoyohimbine, aloyohimbine), which can enhance its performance. With the right dosage, taken with caffeine on an empty stomach and a longer period before taking a meal, it enhances the process of lipolysis due to increased levels of norepinephrine in the body.
In the sports supplementation it helps to reduce body fat (especially in programs of weight control and its composition), taken before physical activity. It comes in the form of mono-preparation supplements, extracts from yohimbe tree bark, synthetics and in supplements with thermogenic effect. Available for purchase at muscle-zone.pl
Dosage: No specific dosage standards. Some sources give optimal dose of 0.2 mg / kg of body weight (usually used at 5-10 mg per day).
Alpha GPC (L-Alpha Glucerylphosphorylcholine, alphaglycerylphosphorylcholine) occurs naturally in the brain and milk. It is a chemical compound (a derivative of choline and its provider in the body) providing a precursor for the synthesis of acetylcholine, which is a neurotransmitter. Probably it has an impact on the secretion of the growth hormone that allows the intensification of tissue regeneration and it is improving the general condition and forming of proper body building.
The medicine uses it in the neurological treatments (stress, depression). In the sports supplementation is rarely used. It is a part of the supplements supporting a night renewal process.
cAMP (cyclic adenosine monophosphate) is an adenosine derivative which is an important component of a variety of biochemical processes necessary for proper functioning of the body. It has a decisive influence on the permeability of cell membranes and stimulates certain hormones (e.g. noradrenaline, glucagon). Participates in the metabolism of amino acids, it is a factor regulating energy conversion within the body. Influences the level of cholesterol in the blood. It synthesizes ATP. Supplements containing cyclic adenosine monophosphate affect the improvement of functional capacity (strength, endurance and concentration) and cause the storage of energy in muscle tissue.
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