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Source Naturals, IP-6 Inositol Hexaphosphate is a dietary supplement containing 2,400 mg of IP (inositol hexaphosphate) per portion. The preparation protects cells from the activity of free radicals, enhances immunity, and improves the functioning of the cardiovascular system.
IP-6 (inositol hexaphosphate), or phytic acid, is the best known phosphorylated carbohydrate occurring in nature. The substrates for the production of phytic acid are inositol and ATP (as a phosphorus donor). A rich source of IP-6 are mainly the seeds of legumes, cereals and oil plants.
According to clinical tests, both in vivo and in vitro, a high content of inositol hexaphosphate in the diet can reduce the risk of developing bowel cancer. Research on the anticancer activity of IP-6 has been conducted since 1988. Moreover, the compound supports the cardiovascular system and exhibits hypocholesterolaemic properties as well as prevents the formation of stones in the kidneys.
What properties inositol phosphate exhibits depends mainly on the degree of its phosphorylation. Derivatives with higher phosphorylation levels, including IP-6, exhibit the ability to form insoluble complexes with multivalent cations, for example cobalt, zinc, calcium, manganese, or copper. Thanks to its ability to chelate multivalent elements, IP-6 helps to remove excess metals from the organism.
Anticancer effect of IP-6
The anticancer properties of IP-6 have significantly increased the interest in the compound, especially in terms of preventing and treating neoplastic diseases. It has been demonstrated that IP-6 can help to inhibit the growth of cells in the case of bowel, prostate, and breast cancers. IP-6 affects such processes as gene expression, the cell cycle, the angiogenesis and metastasis of cancer, and the production of free oxygen radicals.
The mechanism of the anticancer activity of IP-6 is very complex, multifaceted, and depends on the type of cells; however, it is most probably connected with its antioxidant properties. The compound binds F3+ ions, which inhibits the synthesis of free radicals. Moreover, it affects the antioxidant potential of F3+ ions and their homeostasis, thanks to which it helps to protect them from participation in the wrong reactions that can lead to, for example, oxidative DNA damage.
IP-6 also forms complexes with many cations, which helps to reduce their availability in such cases as cell division and DNA biosynthesis, also when it comes to cancer cells. Another example is the ability of IP-6 to bind zinc ions, which contribute to the weakening of thymidine kinase, an enzyme that participates in DNA synthesis, that way inhibiting the growth of a tumour.
IP-6 also reacts with other compounds, for example starch. When combined with phytic acid, starch goes through to the large intestine untransformed, participates in the formation of stool, and that way helps to remove substances that might have carcinogenic properties more efficiently. Additionally, as a result of bacterial fermentation, part of starch can be used to form short-chained fatty acids, which can help to reduce pH in the large intestine and further increase inositol hexaphosphate’s anticancer properties.
Some tests have also demonstrated that IP-6 can affect the regulation of immune responses and inflammations, for example by normalising the production of IL-6.
To sum up, Source Naturals, IP-6 Inositol Hexaphosphate is a dietary supplement that can help to prevent cancer by slowing down the production of cancer cells. The preparation can constitute an efficient weapon in the fight against free oxygen radicals and their negative effect on health. Additionally, it supports the immune system, has a hypocholesterolaemic effect and prevents the formation of stones in kidneys.
The right dosage of IP-6 depends on many factors, like age and general health. Normally, the dosage is about 2 g a day in a few portions, so the amount recommended by the producer is definitely appropriate.
As IP-6 has the ability to chelate elements, it is a good idea not to take the preparation with meals and mineral and multivitamin supplements in order to prevent their potential deficiencies.
Source Naturals is an American vitamin and herbal supplement provider, created in year 1982. The company specialize in producing nutritional formulations for the maintenance of well-being and the enhancement of life – they introduced numerous award-winning formulas, recognized for their excellence in independent surveys and nutritional analyses.
The company also provides education that empowers individuals to take responsibility for their health.
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microcrystalline cellulose, stearic acid, acacia gum, modified cellulose gum, and silica.
Calories are the conventional name of the unit expressing the energy value of food, the demand and energy expenditure in human body, which in fact is 1 kilocalorie (1 kcal). 1 kilocalorie is the amount of thermal energy required to heat 1 g of water and 1 degree Celsius. The SI unit of thermal energy is 1 joule (1J), equal to approximately 4,185 kcal.
The energy value is determined by the chemical composition of the food product, by means of the so-called. physiological equivalents. Most often Atwater equivalent is used: ratio for protein 4 kcal / g, for carbohydrates 4kcal / g, and for fat - 9kcal / g.
The energy value carried out with the so-called. "Caloric bomb" is equivalent to the physical energy, amounting to 4.1 kcal per 1 g carbohydrate to 5.65 kcal per 1 g protein, 9.45 kcal per 1 g of fat.
Nutritional value, determines the suitability of a food product for realizing life functions of human, the higher it is - the higher bioavailability and lower quantity for consumption for obtaining the effects.
Calcium (element chem. symbol Ca, atomic no. 20, the group of alkaline earth metals) is the basic building substance of bones and teeth, in which stored is 99% of the element, in the form of hydroxylapatite. When building bones and teeth, phosphorus is very important in the right proportion. It is a base-forming element and activator of many enzymes (ATPase) necessary to release the energy of ATP. It has a significant effect on blood clotting and regulates blood pressure and neuromuscular conductivity. Thanks to the reduced permeability of cell membranes, it soothes the symptoms of food allergies. Calcium is actively involved in the metabolism of iron interacts with vitamins A, C and D and phosphorus, magnesium. Natural source of calcium are animal products (dairy products, sardines, salmon, sprats eaten with bones) and plant products (nuts, soybeans, sunflower seeds). Absorption takes place in the small intestine (less in the colon), it has an effect on the level of lactose, insoluble fibre, organic acids, alkalinity (low pH). The best absorption have organic compounds (lactates, amino acid chelates etc.). Obstructing the absorption of calcium is caused by: phytic acid and oxalic acid as well as excess fat. Scientific studies have confirmed that the combination of calcium, magnesium, boron and vitamin D in dose 3 mg / 24h effectively prevent osteoporosis. Supplements on the market are both mono-preparation supplements (enriched with vitamin D3) and multi-component supplements, available at www.muscle-zone.pl.
Calcium deficiency disorders manifested in the construction of the bones (osteoporosis) and iron metabolism. The symptoms are: rickets, cramps and muscle tremor, osteoporosis.
Excess resulting from an overdose of calcium supplements containing vitamin D3 for children and adults overdose of calcium (hypercalcemia). Symptoms of hypercalcemia are: lack of appetite, vomiting and constipation.
The dosage administered in various publications are inconsistent: 800 - 1000 mg / 24 h (100 - 500 mg / 24h)
Magnesium (element from the group of alkaline earth metals, atomic no. 12, a chemical symbol - Mg), one of the most important health microelements, participates in the synthesis process of the disintegration of high energy compounds and processes of transformation of hydrocarbons and fats. It affects the dilation of blood vessels and lower blood pressure, prevents hypercoagulable state. Shortages affect cardiac arrhythmias, malignant muscle cramps, insomnia and anxiety. It is a component of many dietary supplements and found in foods such as whole grain bread, legumes, buckwheat, rice, fish, meat, as well as chocolate, cocoa and nuts.
Dosage of 100 - 500 mg / day
Inositol is an organic compound from the group of B vitamins soluble in fluids, present in the natural or synthetic form, synthesized in plants, such as brewer's yeast, beans, grapefruit, cabbage, sprout of wheat, melons and animal (liver). Along with choline is included in the lecithin. It affects the cell nutrition of the central nervous system (brain) by reducing the level of LDL (bad cholesterol), this makes it applicable in treatment of Alzheimer's disease and atherosclerosis. It has a calming effect. There has been a beneficial effect of inositol on the skin and hair reported.
Sodium is an important component of the intracellular fluids, and is a regulator of acid-base balance. Along with potassium affects the proper of growth and provides the proper functioning of muscles and nerves. The source of acquisition is table salt (NaCl) and bladderwrack, shellfish, bacon, beef, and of plant beets and carrots. People on salt-free diet should avoid, among others, spicy sauces and smoked meats and sausages.
Sodium deficiency is very rare, at heaving sweating after a long effort (e.g. in the marathon).
Excess sodium increases blood pressure (especially for the elderly), edema and increased thirst. Exceeding the daily dose of 14g a day can cause poisoning.
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