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Now Foods L-Methionine is a dietary supplement, in the composition of which there is an exogenous amino acid – L-methionine and vitamin B6 in the form of pyridoxine hydrochloride. The recommended dose provides 1 g of L-methionine and 20 mg of vitamin B6.
Methionine (Met) is a sulfuric amino acid (next to cysteine, Cys) and one of eight exogenous (essential) amino acids. The organism of humans and other mammals cannot synthesize methionine, therefore it needs to be provided with food. It appears in the form of L-methionine, as the organism assimilates amino acids with relative configuration L.
Methionine is the most important donor of active methyl groups taking part in the large number of biochemical reactions taking place in the organism. By reacting with ATP, it leads to its breakdown, as a result of which adenosine is produced. Adenosine is then combined with methionine and S-adenosyl methionine (SAMe) is produced, which is a biologically active form of methionine. S-adenosyl methionine is the source of methyl groups in many reactions of methylation, i.a. in the synthesis of adrenaline, noradrenaline, choline and creatine.
After giving up a methyl group, S-adenosyl methionine is converted to S-adenosyl homocysteine, breaking down later to homocysteine and adenosine. Homocysteine may undergo methylation once again to methionine (transmethylation). B-group vitamins are essential for this process (especially vitamins B6, B12 and folates). The results of experimental studies proved that B-group vitamin deficiency, especially vitamin B6, caused metabolism disorders of methionine and excessive production of homocysteine. Increased level of homocysteine leads to the intensification of inflammation, inhibits the growth of endothelial cells and constitutes a risk factor of atherosclerosis.
S-adenosyl methionine takes part in regulating metabolism of neurotransmitters in the brain, such as dopamine and serotonin, the level of which plays a crucial role in controlling mood. Deficiency of these substances is observed in depression and the main effect of antidepressant drugs from SSRI group is based on increasing the level of these neurotransmitters in the brain. Interestingly, research from 2005 proved that supplementation with L-methionine increased the level of SAMe in the organism to a larger extent than supplementation with the preparations with SAMe.
S-adenosyl methionine increases the concentration of glutathione (GSH) in the brain, liver and erythrocytes. Glutathione is a tripeptide with powerful antioxidant properties. The optimal level of glutathione is necessary to maintain oxidative-reductive potential in cells and appropriate processes of detoxification. It protects the organism from oxidative stress of various origins and supports the work of the liver in metabolic processes. Moreover, the increase of the concentration of GSH protects DNA from damages, which consequently prevents mutations and carcinogenesis.
S-adenosyl methionine alleviates joint pain to a comparable extent as nonsteroidal anti-inflammatory drugs (NSAIDs). It is commonly used as support in the therapy of osteoarthritis, bone inflammation and arthritis. Thanks to antioxidant properties, it decreases the production of inflammatory mediators and limits the activity of the pro-inflammatory cytokine TNF-alpha.
To sum up, Now Foods L-Methionine is a dietary supplement with multidirectional, beneficial influence on the organism. It is especially recommended to people prone to depression, dealing with pain in joints and problems with the liver as well as to optimize metabolic processes.
In order to avoid unbeneficial growth of homocysteine level in the organism, one needs to supplement L-methionine along with vitamin B6. The producer took care of an additive of this vitamin to the preparation.
Methionine increases the absorption of iron and selenium.
Now Foods is a company with years of experience in the industry that offers a wide range of nutrients and dietary supplements. Brand is known for its high-quality products designed for hair and nails and supplements supporting the immune system. The offer includes the antioxidant supplements, antibacterial supplements, reducing appetite supplements, products supporting the reduction of body fat and improving digestion. All products are made from natural ingredients.
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|per portion (2 capsules)||amount||%DV|
|Vitamin B-6 (from Pyridoxine HCl)||20 mg||1176%|
|L-Methionine (Free-Form)||1 g (1,000 mg)||†|
Gelatin (capsule), Magnesium Stearate (vegetable source) and Silica.
Exogenous methionine is an amino acid containing sulphur in its composition. It provides multi metabolism, with the indispensable help of vitamin B6. Participates in the synthesis of phospholipids (e.g. Lecithin), carnitine responsible for transport in the body of long-chain fatty acids, burned in the mitochondria cells (organelles in cells with a separate kernel), along with cystine forms cysteine. It is in the body antioxidant function. Natural source of acquisition of methionine are high-protein foods of animal origin (eggs, meat, fish), vegetable (sesame seeds, grain products). Available in all protein and carbohydrate protein and amino acid supplements such EAA and contain so-called all-day amino acids, supporting the liver preparations and cosmetics supporting the growth and condition of hair, skin and nails.
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