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Glycine 1000mg Glycine 1000mg

NOW Glycine 1000 mg is a preparation providing one gram of glycine in its free form in each capsule. By supplementing a diet in this amino acid, important for the work of the organism, it supports the functioning of numerous systems, especially nervous, cardiovascular, digestive or osteoarticular systems as well as the liver. It allows to considerably increase defense and detoxification abilities of the organism, based on antioxidant, anti-inflammatory and immunomodulating mechanisms. It promotes maintaining good psychological condition and when applied in the evening, it effectively prepares the organism for the high-quality night rest. It appears in the form of easy-to-swallow cellulosed capsules and is suitable for vegans.

Glycine – also called α-aminoacetic acid, shortened as Gly, the simplest from the chemical compounds from the group of amino acids, optically inactive, due to having only one atom of hydrogen in the side chain. It was isolated for the first time in 1820. In its form, it resembles crystals, is sweetish in taste and very well-soluble in water. From nutritional point of view, it is considered as a non-essential substance. It is provided to the organism at the amount of 3-5g per day with an average diet. However, there have been more and more reports indicating the need to increase the amount of glycine in order to fulfill the need of the organism for this amino acid.

Glycine as an active substance
It has been considered for a very long period of time as a compound, which does not cause important side effects. Researchers have paid attention only to its constitutional role (participation in creating protein structures). An important property of glycine, apart from being the component of important, biologically active or inactive structures, is its ability to influence glycine receptors (inhibiting transmitters) and N-methyl-D-aspartic receptors (NMDA) (co-agonist supporting activation with glutamate) located in the nervous system. At the same time, when provided from outside, it may work like an active substance. It owes its high effectiveness in the nervous system after the application from outside, to the ability of passive diffusion through blood-brain by unspecific transport. Thanks to this, without major problems it may increase its concentration in the cerebrospinal fluid and influence given receptors, leading to the creation of certain effects.

Properties of glycine

It has immunomodulating, anti-inflammatory and cytoprotective effect
By influencing inflammatory cells, such as e.g. macrophages, it decreases excitability of transcription factors and at the same time the creation of pro-inflammatory cytokines and free radicals. In its application, we observe the drop of the activity of NF-κB, the level of interleukin 6 (IL-6) and TNF-α is lowered, but in turn, the level of interleukin 10 (IL-10) increases, which considerably influences the decrease of the size of inflammations. By influencing the activity of macrophages and increasing the amount of interferon, it effectively increases defense effectiveness of the organism from pathogens. It is believed that for immunomodulating, anti-inflammatory and cytoprotective effects of glycine, its ability to activate chloride channel is responsible, which by interfering with the potential of plasma membrane, inhibits opening calcium channels, dependent on type L and counteracts the growth of intracellular calcium ions, which consequently protects stability of cells.

Increases capacity of antioxidant barrier
Glycine, next to glutamic acid and cysteine, being the component of the structure of glutathione, is an important compound, enabling endogenous synthesis of a given antioxidant compound. By contributing the increasing general pool of glutathione, it takes part in the reduction of mainly hydrogen peroxide and regeneration of other antioxidant compounds, such as vitamin C and E.

Increases effectiveness of detoxification
By enabling the synthesis and increase of the level of glutathione, it supports elimination of many toxic compounds from the organism, including: pesticides, toxins, certain pathogens, e.g. bacteria E. Coli or acetaminophen.

Supports energy balance in the organism
Being a glucogenic amino acid, easy to convert in glucose, it constitutes an important energy substrate. By stimulating the secretion of intestinal hormone (glucagon), it supports insulin in positioning glucose in the organism. After intensive physical effort, it considerably supports glycogen reconstruction, a reservoir of carbohydrates which constitutes an important store of energy substrates. As one of essential ingredients enabling the course of endogenous creatine synthesis, in ensures the organism the ability to create a transporter and store of high-energy compounds, such as e.g. adenosine-5’-triphosphate (ATP).

Ensures proper condition of the cardiovascular system
By taking part in heme synthesis, it ensures the ability to safely transport oxygen in vessels. By strengthening antioxidant barrier in the organism, it supports unwavering functioning of the processes responsible for maintaining proper blood pressure. It supports stabilization of plaques. By additionally protecting cells of the circulatory system from excessive oxidative stress, including reduction of size of peroxidation of lipids, circulating in the circulatory system and counteracting the processes of hemoglobin glycation in the system with disturbed carbohydrate-insulin balance, it enables maintaining proper structures of the circulatory system and their ability to perform their assigned function.

Supports the work of the nervous system
By influencing glycine receptors in the way that plays a role of an inhibiting neurotransmitter and by interfering with the activity of N-methyl-D-aspartic receptors (NMDA), thanks to which it supports their activation with glutamate, it is engaged in the work of the nervous system. By demonstrating vasoactive properties, promoting widening of blood vessels and facilitating microcirculation in the brain, it supports nutrition, oxygenation and detoxification of the organ, important for the nervous system. By reducing the amounts of stored cholesterol, phospholipids, triglycerides and free fatty acids in the brain during excessive consumption of alcohol, it limits the appearance of swelling in the brain.

Facilitates regeneration processes of bones and joints
By increasing proliferation of osteoblasts in an incorporation of BrdU as well as expression of mRNA Ki-67 in cells, it considerably increases mineral density of bones, trabecular number and density of connections in their structures, which is reflected in the pace of bone revival. It is assumed, that it demonstrates estrogen-similar osteoporotic effect. It is especially visible in women during menopause. Glycine support is also important in regeneration of tendons after injuries.

Supports proper work of the liver
By increasing the amount of glutathione in the liver, the size of damages to hepatocytes causing excessive oxidative activity and accumulation of toxins is decreased. By delaying the absorption of alcohol from the digestive system, it facilitates liver to deal with alcohol. By reducing the storage of triglycerides, cholesterol, free fatty acids and phospholipids in the liver in the period of excessive intake of alcohol, the symptoms of fatty liver are decreased. By ensuring the required composition of bile acids and proper functioning of mitochondria in the period of excessive damage to liver structures, it takes care about its proper functionality.

Supports functionality of kidney structures
By supporting maintaining the structures of nephrons in the period of ischemia, it is conducive to maintaining these structures and at the same time it supports proper functions of kidneys.

Takes care about good condition of the digestive system
By supporting the functioning of the antioxidant barrier, it reduces the size of oxidative stress, constituting danger for the integrity of cells of the immune system. By decreasing the secretion of hydrochloric acid and decreasing oxidative stress endangering the integrity of stomach mucosa, it contributes to maintaining good state of a given part of the digestive system. By the same token, it decreases the number of stomach damages caused by alcohol. By decreasing the feeling of stomachache, caused by the application of acetylsalicylic acid, it improves its tolerance. By limiting the size of inflammations, it improves the functionality of smooth muscles in the intestines.

Decreased tooth decay
By interfering with the lipid composition of teeth, without the influence on calcium or phosphorus retention, it allows to create teeth more resilient to decay.

Facilitates falling asleep and improves sleep quality
Glycine applied from outside shortens the time needed to fall asleep and improves both subjective and objective sleep quality. After an hour from application, the following symptoms are visible: lower body temperature and widening of blood vessels, preparing the organism for the night rest. NREM phase is considerably shortened, enabling falling faster into the phase of deep sleep. Improved sleep quality entails lower fatigue the next dat. The main mechanisms of glycine improving sleep quality are: the influence on NMDA receptors, modulating the expression of some peptides, i.a. arginine vasopressin (AVP) and vasoactive intestinal polypeptide (VIP) and also increasing extracellular release of serotonin in the frontal cortical part.

Supports maintaining good mental state
By supporting restoring serine/glycine balance at the moment of disturbing its concentration in the plasma for the benefit of serine and balancing some other amino acids, such as taurine and glutamate, it promotes maintaining psychological balance. By enabling balancing the proportions created with chosen amino acids and influencing NMDA receptors as well as improving sleep quality, it allows to decrease depression and introduce better mood and attitude to world. Moreover, by means of NMDA receptors, it decreases the symptoms of obsessive-compulsive disorders (OCD).

Supports body mass control
By increasing the concentration of adiponectin, it influences metabolism of carbohydrates and fats, facilitating body mass control. Additionally, it is believed that important effect supporting weight control may take place thanks to the properties of glycine, supporting the secretion of glucagon-like peptide-1 (GLP-1), glucagon and leading to limiting the pace of lipogenesis, indirect influence on the activity of cAMP and AMPK.

NOW Glycine 1000 mg is a mono-preparation, supplementing a diet with an amino acid, important for the functioning of the human organism, glycine. By constituting an important element building numerous structures of the organism, it ensures proper functioning of proteins. By creating an important building block of glutathione, a compound constituting a pillar of antioxidant barrier and strong link of detoxification processes, it allows to maintain proper balance. It also controls unwavering functions of many systems, including nervous, digestive, circulatory, osteoarticular and immune systems, as well as organs, such as liver or kidneys. Thanks to its unique properties, fulfilled in the nervous system, it allows to maintain psychological balance. When applied in the evening, it calms down the organism, preparing it for sleep and modulates its course in order to ensure the highest-quality night sleep. Closing glycine in gelatin-free capsules makes it suitable also for vegans.  

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Glycine 1000mg Glycine 1000mg 100 caps.
Now Foods
£ 10.11

Glycine 1000mg 100 caps.

Servings: 100 caps.
1-2
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EU Stock
Availability:
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Minimum expiration date:
2022-05
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Description
  • Glycine in the free form
  • Important structural element of proteins
  • Important component of glutathione
  • Strengthens antioxidant barrier
  • Limits the size of inflammations
  • Accelerates detoxification processes
  • Significantly influences neurotransmission
  • Takes care about good state of the nervous system
  • Promotes maintaining psychological balance
  • Supports relaxation of the organism
  • Prepares the organism for night rest
  • Ensures better sleep quality
  • Supports cardiovascular system
  • Takes care about the condition of the digestive system
  • Maintains functionality of the liver
  • Supports regeneration of bones and joints
  • Decreases susceptibility of teeth to caries
  • Supports body mass control
  • Closed in cellulosed capsules
  • Suitable for vegans

NOW Glycine 1000 mg is a preparation providing one gram of glycine in its free form in each capsule. By supplementing a diet in this amino acid, important for the work of the organism, it supports the functioning of numerous systems, especially nervous, cardiovascular, digestive or osteoarticular systems as well as the liver. It allows to considerably increase defense and detoxification abilities of the organism, based on antioxidant, anti-inflammatory and immunomodulating mechanisms. It promotes maintaining good psychological condition and when applied in the evening, it effectively prepares the organism for the high-quality night rest. It appears in the form of easy-to-swallow cellulosed capsules and is suitable for vegans.

Glycine – also called α-aminoacetic acid, shortened as Gly, the simplest from the chemical compounds from the group of amino acids, optically inactive, due to having only one atom of hydrogen in the side chain. It was isolated for the first time in 1820. In its form, it resembles crystals, is sweetish in taste and very well-soluble in water. From nutritional point of view, it is considered as a non-essential substance. It is provided to the organism at the amount of 3-5g per day with an average diet. However, there have been more and more reports indicating the need to increase the amount of glycine in order to fulfill the need of the organism for this amino acid.

Glycine as an active substance
It has been considered for a very long period of time as a compound, which does not cause important side effects. Researchers have paid attention only to its constitutional role (participation in creating protein structures). An important property of glycine, apart from being the component of important, biologically active or inactive structures, is its ability to influence glycine receptors (inhibiting transmitters) and N-methyl-D-aspartic receptors (NMDA) (co-agonist supporting activation with glutamate) located in the nervous system. At the same time, when provided from outside, it may work like an active substance. It owes its high effectiveness in the nervous system after the application from outside, to the ability of passive diffusion through blood-brain by unspecific transport. Thanks to this, without major problems it may increase its concentration in the cerebrospinal fluid and influence given receptors, leading to the creation of certain effects.

Properties of glycine

It has immunomodulating, anti-inflammatory and cytoprotective effect
By influencing inflammatory cells, such as e.g. macrophages, it decreases excitability of transcription factors and at the same time the creation of pro-inflammatory cytokines and free radicals. In its application, we observe the drop of the activity of NF-κB, the level of interleukin 6 (IL-6) and TNF-α is lowered, but in turn, the level of interleukin 10 (IL-10) increases, which considerably influences the decrease of the size of inflammations. By influencing the activity of macrophages and increasing the amount of interferon, it effectively increases defense effectiveness of the organism from pathogens. It is believed that for immunomodulating, anti-inflammatory and cytoprotective effects of glycine, its ability to activate chloride channel is responsible, which by interfering with the potential of plasma membrane, inhibits opening calcium channels, dependent on type L and counteracts the growth of intracellular calcium ions, which consequently protects stability of cells.

Increases capacity of antioxidant barrier
Glycine, next to glutamic acid and cysteine, being the component of the structure of glutathione, is an important compound, enabling endogenous synthesis of a given antioxidant compound. By contributing the increasing general pool of glutathione, it takes part in the reduction of mainly hydrogen peroxide and regeneration of other antioxidant compounds, such as vitamin C and E.

Increases effectiveness of detoxification
By enabling the synthesis and increase of the level of glutathione, it supports elimination of many toxic compounds from the organism, including: pesticides, toxins, certain pathogens, e.g. bacteria E. Coli or acetaminophen.

Supports energy balance in the organism
Being a glucogenic amino acid, easy to convert in glucose, it constitutes an important energy substrate. By stimulating the secretion of intestinal hormone (glucagon), it supports insulin in positioning glucose in the organism. After intensive physical effort, it considerably supports glycogen reconstruction, a reservoir of carbohydrates which constitutes an important store of energy substrates. As one of essential ingredients enabling the course of endogenous creatine synthesis, in ensures the organism the ability to create a transporter and store of high-energy compounds, such as e.g. adenosine-5’-triphosphate (ATP).

Ensures proper condition of the cardiovascular system
By taking part in heme synthesis, it ensures the ability to safely transport oxygen in vessels. By strengthening antioxidant barrier in the organism, it supports unwavering functioning of the processes responsible for maintaining proper blood pressure. It supports stabilization of plaques. By additionally protecting cells of the circulatory system from excessive oxidative stress, including reduction of size of peroxidation of lipids, circulating in the circulatory system and counteracting the processes of hemoglobin glycation in the system with disturbed carbohydrate-insulin balance, it enables maintaining proper structures of the circulatory system and their ability to perform their assigned function.

Supports the work of the nervous system
By influencing glycine receptors in the way that plays a role of an inhibiting neurotransmitter and by interfering with the activity of N-methyl-D-aspartic receptors (NMDA), thanks to which it supports their activation with glutamate, it is engaged in the work of the nervous system. By demonstrating vasoactive properties, promoting widening of blood vessels and facilitating microcirculation in the brain, it supports nutrition, oxygenation and detoxification of the organ, important for the nervous system. By reducing the amounts of stored cholesterol, phospholipids, triglycerides and free fatty acids in the brain during excessive consumption of alcohol, it limits the appearance of swelling in the brain.

Facilitates regeneration processes of bones and joints
By increasing proliferation of osteoblasts in an incorporation of BrdU as well as expression of mRNA Ki-67 in cells, it considerably increases mineral density of bones, trabecular number and density of connections in their structures, which is reflected in the pace of bone revival. It is assumed, that it demonstrates estrogen-similar osteoporotic effect. It is especially visible in women during menopause. Glycine support is also important in regeneration of tendons after injuries.

Supports proper work of the liver
By increasing the amount of glutathione in the liver, the size of damages to hepatocytes causing excessive oxidative activity and accumulation of toxins is decreased. By delaying the absorption of alcohol from the digestive system, it facilitates liver to deal with alcohol. By reducing the storage of triglycerides, cholesterol, free fatty acids and phospholipids in the liver in the period of excessive intake of alcohol, the symptoms of fatty liver are decreased. By ensuring the required composition of bile acids and proper functioning of mitochondria in the period of excessive damage to liver structures, it takes care about its proper functionality.

Supports functionality of kidney structures
By supporting maintaining the structures of nephrons in the period of ischemia, it is conducive to maintaining these structures and at the same time it supports proper functions of kidneys.

Takes care about good condition of the digestive system
By supporting the functioning of the antioxidant barrier, it reduces the size of oxidative stress, constituting danger for the integrity of cells of the immune system. By decreasing the secretion of hydrochloric acid and decreasing oxidative stress endangering the integrity of stomach mucosa, it contributes to maintaining good state of a given part of the digestive system. By the same token, it decreases the number of stomach damages caused by alcohol. By decreasing the feeling of stomachache, caused by the application of acetylsalicylic acid, it improves its tolerance. By limiting the size of inflammations, it improves the functionality of smooth muscles in the intestines.

Decreased tooth decay
By interfering with the lipid composition of teeth, without the influence on calcium or phosphorus retention, it allows to create teeth more resilient to decay.

Facilitates falling asleep and improves sleep quality
Glycine applied from outside shortens the time needed to fall asleep and improves both subjective and objective sleep quality. After an hour from application, the following symptoms are visible: lower body temperature and widening of blood vessels, preparing the organism for the night rest. NREM phase is considerably shortened, enabling falling faster into the phase of deep sleep. Improved sleep quality entails lower fatigue the next dat. The main mechanisms of glycine improving sleep quality are: the influence on NMDA receptors, modulating the expression of some peptides, i.a. arginine vasopressin (AVP) and vasoactive intestinal polypeptide (VIP) and also increasing extracellular release of serotonin in the frontal cortical part.

Supports maintaining good mental state
By supporting restoring serine/glycine balance at the moment of disturbing its concentration in the plasma for the benefit of serine and balancing some other amino acids, such as taurine and glutamate, it promotes maintaining psychological balance. By enabling balancing the proportions created with chosen amino acids and influencing NMDA receptors as well as improving sleep quality, it allows to decrease depression and introduce better mood and attitude to world. Moreover, by means of NMDA receptors, it decreases the symptoms of obsessive-compulsive disorders (OCD).

Supports body mass control
By increasing the concentration of adiponectin, it influences metabolism of carbohydrates and fats, facilitating body mass control. Additionally, it is believed that important effect supporting weight control may take place thanks to the properties of glycine, supporting the secretion of glucagon-like peptide-1 (GLP-1), glucagon and leading to limiting the pace of lipogenesis, indirect influence on the activity of cAMP and AMPK.

NOW Glycine 1000 mg is a mono-preparation, supplementing a diet with an amino acid, important for the functioning of the human organism, glycine. By constituting an important element building numerous structures of the organism, it ensures proper functioning of proteins. By creating an important building block of glutathione, a compound constituting a pillar of antioxidant barrier and strong link of detoxification processes, it allows to maintain proper balance. It also controls unwavering functions of many systems, including nervous, digestive, circulatory, osteoarticular and immune systems, as well as organs, such as liver or kidneys. Thanks to its unique properties, fulfilled in the nervous system, it allows to maintain psychological balance. When applied in the evening, it calms down the organism, preparing it for sleep and modulates its course in order to ensure the highest-quality night sleep. Closing glycine in gelatin-free capsules makes it suitable also for vegans.  

Directions for use
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Composition

Container size: 100 capsulesServing size: 3 capsulesServings per container: 33
per portion (3 capsules)amount%DV
Glycine (Free-Form) 3000 mg-

Other ingrednients

Cellulose (capsule), Cellulose Powder, Magnesium Stearate (vegetable source) and Silica.

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Glycine

Information

Glycine is belongs to 22 essential amino acids (synthesized within the body) constructing proteins, and non-protein component of enzymes i.e. heme. It is a inhibiting neurotransmitter allowing for improvement in sleep comfort even at a dose of 3 g at bedtime. Glycine (as arginine) is a precursor of creatine. It is essential for the synthesis of a strong antioxidant - removing free radicals out of the body - glutathione. It is cholagogic and cholepoiteic. By interfering with the synthesis of growth hormone, accelerates the biological recovery of an organism. Naturally present in foods of plant and animal origin. In the sports supplementation is a component creatine stacks, amino acid supplements, protein supplements based on natural ingredients and carbohydrate and protein.


 

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