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Doctor’s Best Collagen Types 1 & 3 is a dietary supplement which contains the highest-quality collagen proteins types 1 and 3, which underwent enzymatic hydrolysis in order to guarantee the proper amino acid content and effectiveness. The product is additionally enriched with vitamin C, which is involved in the synthesis of collagen and promotes the proper condition of connective tissue.
The supplement supports the treatment of bone and joint diseases as well as improves the condition of skin, hair and nails. Moreover, it positively affects joint mobility and increases comfort of exercising.
Collagen is a common extracellular protein which is the basic structural component of dermis. Collagen proteins make up for 1/3 of all proteins in the body system, and they are present also in ligaments, tendons, cartilage and cornea.
The main function of collagen is the maintenance of the proper structural integrity of connective tissue, its elasticity and resistance to stretching. Collagen type 1 is present mainly in the skin, bones, ligaments and tendons, while collagen type 3 – in the skin, blood vessels and intestines.
Until now, 29 genetically different forms of collagen were described. Their common characteristic was the presence of super-helix, a triple helix. Super-helix is stabilised mainly due to the presence of glycine and large amounts of proline and hydroxyproline. All proteins from collagen group are built only of endogenous amino acids.
Collagen and ageing
With age, the ratio of collagen synthesis drops. Also the activity of enzymes involved in posttranslatic modifications is lower, and collagen fibres become thinner. Already after the age of 25, the human body system loses its ability to keep the balance between synthesis and degradation of collagen, which results in deterioration of skin and nails condition, impaired functioning of blood and lymphatic vessels as well as can lead to serious consequences, like arthritis or osteodystrophy.
Moreover, with age we can observe impaired functioning of fibroblasts, which results in slower production and exchange of collagen. Impaired collagen metabolism contributes not only to dysfunctions within mobility, whose symptoms include stiffness and joint pain, but it also negatively affects tissues and organs, for which collagen is important.
Collagen – a protein important for skin
As the most important component of extracellular matrix, collagen is crucial for skin, as it is responsible for its elasticity and durability. Collagen type 1 is the most common in the skin and is a fibrous support for skin, while collagen type 3 entangles collagen fibres type 1 and determines their proper arrangement. Impaired collagen metabolism can be a cause for premature wrinkles, skin damage and discolouration.
Collagen can restore young appearance of skin, counteract hair loss and add brigthness, strengthen the nail plate and prevent its splitting.
Collagen for the proper functioning of bones and joints
Collagen type 1 makes up for 85–95% of all organic substances in bones. It is responsible for the tissue resistance to stretching and bone hardness.
Collagen hydrolysate promotes joint protection and can contribute to the reduction of pain resulting from overburden or injuries. Collagen supplementation can also contribute to the restoration of joint cartilage.
To sum it all up, Doctor’s Best Collagen Types 1 & 3 is a dietary supplement which brings many benefits for both health and beauty. It is intended for people being at risk of damaged joints resulting from overburden and other factors which can negatively affect joint structure.
The product is also recommended for elderly people, athletes and people struggling with autoaggressive diseases (osteoarthritis). Also obese people who put their joint at risk of increased burden should take care of the proper collagen level in the body system.
Collagen supplementation is recommended not only in case of first pain symptoms, morning stiffness and reduced joint mobility. It is also worth to start the supplementation if we know that our joint are going to be excessively burden, e.g. as a result of intensive preparation for competition.
For optimal absorption, collagen should be taken on an empty stomach. It is suggested to take the first recommended dosage when fasting and refrain from eating a meal for at least 30 minutes, and the second one before sleep, at least an hour after the last meal.
Preparations containing collagen should never be combined with proteins, including those in the form of high protein ready meals. Proteins impede collagen absorption and prevent some amino acids from being assimilated by the organism.
Physician-founded in 1990, Doctor’s Best is a science-based nutritional supplement company, offering more than 200 products, made primarily with branded ingredients that are thoroughly researched, manufactured to the highest quality standards, and rigorously tested every step of the way—from raw materials to finished product. We use only cGMP-certified manufacturing facilities. Doctor’s Best is committed to transparency through education and communication and strives to be crystal clear in what we offer, why and how we offer it.
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Gelatin (capsule), microcrystalline cellulose.
Vitamin C (ascorbic acid) it is a vitamin soluble in body fluids, can be taken from foods (fruits and vegetables), or as drug derived synthetically. The largest of its resources can be found in broccoli, Brussels sprout, kale, black currant fruit and hawthorn, citrus fruits, tomatoes, Savoy cabbage, potatoes. In fact, intake of vitamin C of the food products does not limit the absorbed quantity. Vitamin C (ascorbic acid) is a potent antioxidant, it is an antitoxic, increasing the immune system due to the elimination of risk of bacterial contamination. Vitamin C prevents rupture of blood vessels, affects the blood cholesterol level. It substantially increases the absorption of iron. Inhibits the growth of cancer cells. Lowers stress levels.
Vitamin C deficiency causes abnormal development of connective tissue, cracking capillaries, abnormal calcification of bone tissue, impaired absorption of iron, scorbutus. With the lack of vitamin C, all kinds of injuries do not heal up properly. Vitamin C deficiency can be caused by smoking; each cigarette is destroying up to 100 mg of vitamin C.
Dosage: The demand is 60-80 mg daily. It does not limit the ability to consume higher doses. Some side effects may occur only with longer taking of synthetic vitamin C.
Calcium (element chem. symbol Ca, atomic no. 20, the group of alkaline earth metals) is the basic building substance of bones and teeth, in which stored is 99% of the element, in the form of hydroxylapatite. When building bones and teeth, phosphorus is very important in the right proportion. It is a base-forming element and activator of many enzymes (ATPase) necessary to release the energy of ATP. It has a significant effect on blood clotting and regulates blood pressure and neuromuscular conductivity. Thanks to the reduced permeability of cell membranes, it soothes the symptoms of food allergies. Calcium is actively involved in the metabolism of iron interacts with vitamins A, C and D and phosphorus, magnesium. Natural source of calcium are animal products (dairy products, sardines, salmon, sprats eaten with bones) and plant products (nuts, soybeans, sunflower seeds). Absorption takes place in the small intestine (less in the colon), it has an effect on the level of lactose, insoluble fibre, organic acids, alkalinity (low pH). The best absorption have organic compounds (lactates, amino acid chelates etc.). Obstructing the absorption of calcium is caused by: phytic acid and oxalic acid as well as excess fat. Scientific studies have confirmed that the combination of calcium, magnesium, boron and vitamin D in dose 3 mg / 24h effectively prevent osteoporosis. Supplements on the market are both mono-preparation supplements (enriched with vitamin D3) and multi-component supplements, available at www.muscle-zone.pl.
Calcium deficiency disorders manifested in the construction of the bones (osteoporosis) and iron metabolism. The symptoms are: rickets, cramps and muscle tremor, osteoporosis.
Excess resulting from an overdose of calcium supplements containing vitamin D3 for children and adults overdose of calcium (hypercalcemia). Symptoms of hypercalcemia are: lack of appetite, vomiting and constipation.
The dosage administered in various publications are inconsistent: 800 - 1000 mg / 24 h (100 - 500 mg / 24h)
Sodium is an important component of the intracellular fluids, and is a regulator of acid-base balance. Along with potassium affects the proper of growth and provides the proper functioning of muscles and nerves. The source of acquisition is table salt (NaCl) and bladderwrack, shellfish, bacon, beef, and of plant beets and carrots. People on salt-free diet should avoid, among others, spicy sauces and smoked meats and sausages.
Sodium deficiency is very rare, at heaving sweating after a long effort (e.g. in the marathon).
Excess sodium increases blood pressure (especially for the elderly), edema and increased thirst. Exceeding the daily dose of 14g a day can cause poisoning.
Collagen is a major component that builds connective tissue (tendons, ligaments cartilage, bone, and blood vessels) from the group of fibrous proteins (i.e. scleroprotein), representing a quarter of the content of protein in the body. It is composed of amino acids (glycine, hydroxylysine, hydroxyproline and proline). Distinguished are eight types of collagen located in different parts of the human body. The source of the acquisition is gelatin (a component of the connective tissue of animal origin). It occurs most frequently in the form of processed collagen hydrolyzate characterized by a high and a good absorbency of amino acids. Recommended in sports supplementation and physically active people, as well as during convalescence after injuries and certain diseases. Available as mono-preparation supplement or of multi-compound supplement (usually also containing chondroitin, hyaluronic acid, and ascorbic acid).
Dosage: 10-20 g per day.
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