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|Servings: 60 caps.|
The preparation is in the form of capsules, thanks to which it is characterized by high effectiveness. It was proven that the time of the capsule’s breakdown is 4 times shorter than in case of a tablet, which means that vitamin D3 in this form may demonstrate considerably higher bioavailability.
Vitamin D3, discovered in 1922 by McCollum, since recently, it has been one of the most valued vitamins. Currently, it is more often called a prohormone. Vitamin D3, also called cholecalciferol, is produced in skin from 7-dehydrocholesterol, under the influence of UVB radiation. It may be also obtained with food.
It was believed for a long time that the role of vitamin D is mainly based on maintaining proper bone metabolism and calcium balance. This changed when in 1979, thanks to Stumpf laboratory, a receptor for vitamin D was discovered - VDR (Vitamin D Receptor) and it was proven that it is present in the majority of human extra-skeletal cells. This caused that vitamin D started to be attributed an increasingly higher and meaningful role in the functioning of the whole organism. Currently, its important participation in immunological and anticarcinogenic processes is highlighted.
Vitamin D deficiency is a very common phenomenon all around the world in all age groups. Both insufficient synthesis of vitamin D under the influences of sun, resulting from i.a. geographical and seasonal differentiation as well as insufficient supply with a diet (including also coexisting absorption deficiencies and diseases inhibiting absorption) only deepen this problem.
Recent research proved that deficiency of vitamin D may be the cause of many diseases, including: cancers, diabetes, hypertension, autoimmune diseases, neurological diseases, diseases of the skeletal system (decreased movement efficiency, worse work of muscles).
The influence of vitamin D3 on the skeletal and muscle system is the best-known. This vitamin enables proper bone mineralization, maintains proper relation between bone formation and resorption, at the same time reducing bone turnover and leading to the increase of bone mass.
Vitamin D also takes part in the activation of numerous metabolic processes taking place in muscle tissue. This vitamin i.a. stimulates the synthesis of protein and influences the proliferation of muscle cells. It was proven that even slight deficiency of vitamin D3 may lead to decreasing the strength of skeletal muscles. Its proper supply positively influences their functioning and facilitates regeneration e.g. after fractures.
Immunomodulating effect of vitamin D is related to i.a. its influence on the level of cathelicidin. Cathelicidin is a peptide characterized by a wide spectrum of antibacterial effects. It was proven that increasing active metabolites of vitamin D in blood contributes to the increased synthesis of the above mentioned peptide. Moreover, vitamin D leads to decreasing inflammatory reaction (it decreases the level of pro-inflammatory cytokines and increases the level of anti-inflammatory cytokines), counteracting chronic inflammations and autoimmune diseases, such as: rheumatoid arthritis, non-specific inflammatory bowel disease, fybromyalgia.
Vitamin D demonstrates neuroprotective effect, related mainly to its ability to stimulate the synthesis of neurotransmitters and especially dopamine, the insufficient level of which is the only active factor of Parkinson’s disease. It was proven that deficiency of vitamin D influences deterioration of well-being and the occurrence of depression symptoms and it often accompanies people dealing with cognitive disorders.
To sum up, Doctor's Best Vegan D3 2500 IU is a dietary supplement, which helps to level up deficiency of vitamin D. It is especially recommended to people who avoid exposure to sun and whose diet is poor in products which are the source of vitamin D.
It is also recommended in the winter period, during which skin synthesis of vitamin D is decreased (it helps to decrease the frequency of upper respiratory tract infections). Including vitamin D to constant supplementation may be also one of the key elements of prophylaxis of civilization diseases, and it may also constitute perfect support for physically active people.
Vitamin D is characterized by long half-life and it is stored in the organism, therefore it is best to take the recommended dose e.g. every second day or (in higher doses) even once a week. However, it is most effective to supplement vitamin D according to its level in blood.
Vitamin D is a compound soluble in fats, therefore in order to ensure the best absorption, it should be taken with a meal containing fat.
Physician-founded in 1990, Doctor’s Best is a science-based nutritional supplement company, offering more than 200 products, made primarily with branded ingredients that are thoroughly researched, manufactured to the highest quality standards, and rigorously tested every step of the way—from raw materials to finished product. We use only cGMP-certified manufacturing facilities. Doctor’s Best is committed to transparency through education and communication and strives to be crystal clear in what we offer, why and how we offer it.
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Microcrystalline cellulose, modified cellulose (vegetarian capsule), maltodextrin, starch, sucrose, silicon dioxide, d-alpha tocopherol, ascorbyl palmitate.
Vitamin D belongs to fat soluble vitamins, occurs in three forms: calciferol (vitamin D1) ergocalciferol (vitamin D2) and cholecalciferol (vitamin D3), it is formed under the action of sunlight for at least 15 minutes per day. In the absence of sunlight it should be administered in the diet in the form of fish oil (Vitamin A + D3) and fish oils. It is responsible for the absorption of calcium and phosphorus. It is the building substance of bone tissue particularly necessary during pregnancy, childhood, and for athletes. It is a component of dietary supplements and nutrients among competetive athletes. Deficiency of vitamin D causes children growth inhibition, and rickets.
For adults - deficiency causes osteomalacia.
Excess of vitamin D causes headaches, alopecia, nausea, drowsiness, blurred vision, pain in the long bones, the deposition of calcium deposits.
Dosage: 400 IU units during the day.
Cholecalciferol, or vitamin D3, is an organic chemical that belongs to the family of D vitamins. It is naturally found in fatty fish, fish oil, egg yolks, milk and dairy products. It is also synthesized in the human body. It is formed from 7-dehydrocholesterol present in the keratinocytes of the spinous and the basal layers of the epidermis, and a pre-requisite for initiating this process is the action of 290-315 nm wavelength UVB radiation on the skin.
Cholecalciferol is a biologically inactive compound. In the body, it undergoes enzymatic hydroxylation – first in the liver, with the participation of 25-hydroxylase, when calcidiol is formed and secondly in the kidneys, where under the influence of 1-α-hydroxylase, calcidiol is converted into the final active form – calcitriol.
The most important role of vitamin D3 in the body is the regulation of calcium-phosphate metabolism, which directly affects normal skeletal mineralization. In addition, it is involved in cell proliferation and differentiation, insulin secretion, as well as in some functions of the nervous, endocrine and immune systems.
Cholecalciferol is the most popular form of vitamin D used in dietary supplements. Studies show that supplementation with vitamin D in this form most effectively and rapidly raises the level of 25 (OH) D3 – a metabolite that is a marker of the level of vitamin D in the body.
Dosage: according to RDI standards for individual age groups.
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