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Lactibiane Tolerance Lactibiane Tolerance 30 caps.
£ 26.39

Lactibiane Tolerance 30 caps.

Servings: 30 caps.
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  • Professional lactic acid bacteria supplement
  • Five selected probiotic strains
  • Support for digestive system function
  • Intestinal microbiome homeostasis restoration
  • Regulation of immune system function
  • Aid for irritable bowel syndrome therapy
  • Large dose of probiotic bacteria
  • Suitable for vegetarians
  • Gluten-free product
  • Lactose-free

Lactibiane Tolerance is another professional dietary supplement developed by the French company PiLeJe. As a combination of as many as 5 probiotic bacterial strains, it exhibits a wide range of health-promoting properties, especially in terms of the digestive and immune systems. Its main activity is directed especially at restoring the intestinal microbiome balance and helping in inflammatory disorders of the digestive system.

The preparation was created out of five specially selected lactic acid bacterial strains: Bifidobacterium lactis LA 303, Lactobacillus acidophilus LA 201, Lactobacillus plantarum LA 301, Lactobacillus salivarius LA 302, Bifidobacterium lactis LA 304. All the strains listed above are deposited and registered in the French Pasteur Institute, which confirms their efficacy.

The 21st century is a time of incredibly intensive development of society and medicine. Unfortunately, along with the progress, some mechanisms and behaviours that had determined the human organism for thousands of years changed suddenly. The progress of hygiene, limited (sometimes extremely) contact with various microorganisms, excessive use of drugs (antibiotics, analgesics) or psychoactive substances (coffee, alcohol), or a bad diet can distort those processes.

A crucial problem here is the digestive system and the microorganisms that live in it, as their functioning is reflected in the entire organism. A poor composition of the intestinal microbiome and its distortion by pathogenic bacterial strains can be a reason of many serious consequences for health, including gut barrier leaking, autoimmune disorders, problems with gastrointestinal tract peristalsis and digestion, and even bowel cancer.

Normal intestinal microbiome composition
The progress in hygiene, excessive and maladjusted use of antibiotics, and an improper diet can significantly affect the composition of the microorganisms present in the digestive system of a grown person. It can lead to situations when harmful bacteria and fungi gain advantage and crowd out the positive ones.

The basic and thoroughly-tested ability of probiotics is to settle mainly in the large intestine, and to a much smaller extent in the small intestine. It means that they overtake the area from pathogenic bacteria and prevent their new development. Lactic acid bacteria can also produce various substances with microbicidal properties, which means that they work similarly to antibiotics with the only difference that they can destroy bacterial strains selectively, usually only those dangerous for health.

They also produce great amounts of lactic acid, which makes the intestinal environment more acidic. Pathogenic bacteria and fungi are usually not adjusted to living in such conditions, thanks to which the risk of their overgrowth is reduced.

Leaky gut syndrome
The walls of the gastrointestinal tract with the immune system located in it is the basic barrier that stops bacteria and viruses from permeating into the organism. Unfortunately, lack of balance in the microbiome composition, excessive use of antibiotics or analgesics, an improper diet, or frequent infections can lead to disorders in its stability.

According to many specialists, that situation is one of the factors responsible for the development of many diseases. Too intensive permeation of various substances through intestinal walls can cause excessive immune response, which is the beginning of allergies and sensitive to various substances.

Leaky gut can also lead to the permeation of large molecules and pathogens inside the organism, which can lead to disorders in the physiology of many organs, including the brain, general or local inflammations, especially within the bowel.

Probiotics have a few mechanisms that can prevent those conditions. Firstly, as mentioned before, they can crowd out harmful bacteria, that way preventing intestinal wall damage caused by them. Some strains also produce large amounts of butyric and propionic acids, which are the main source of energy for colonocytes – the cells that form large intestine walls. That, in turn, enables their regeneration and normal development.

Some specific strains are also characterised by some influence on the functioning of the lymphatic system. By stimulating specific elements of the system, they can also increase the activity of some lymphocyte subpopulations, inhibiting the production of pro-inflammatory substances by them and their excessive mobilisation in response to harmless molecules.

Irritable bowel syndrome (IBS)
One of the factors determining the development of the ailment, apart from stress and genetic predispositions, is distorted intestinal microbiome composition. Probiotics can prove therapeutically helpful in that aspect as well.

Apart from restoring the right bacterial composition, they can prevent some symptoms of the disease, such as flatulence, abdominal pains, or diarrhoea. In people with predispositions, properly adjusted supplementation can have a preventive effect, protecting the organism from the development of IBS.

Digestion support
Lactic acid bacterial strains can also affect digestive processes and the general condition of the digestive system. Thanks to the secretion of appropriate enzymes, they support the digestion of some nutrients, including lactose, whose intolerance can be very bothersome and exhausting.

By supporting the regeneration of intestinal walls and mucosa, they can also help to improve the functioning of intestinal villi and natural digestive processes. They also exhibit the ability to regulate peristalsis, thanks to which nutrients can be broken down and absorbed into the circulatory system more efficiently.

To sum up, Lactibiane Tolerance is a dietary supplement that supports the normal functioning of the digestive system in a versatile way. It is particularly recommended for people who want to take care of the right intestinal microbiome composition in order to prevent the development of many serious diseases. It can also be adjusted to serve as an aid in the treatment of the irritable bowel syndrome and the leaky gut syndrome. 

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Container size: 30 capsulesServing size: 1 capsuleServings per container: 30
per 1 capsuleamount%DV
Bifidobacterium lactis LA 30310x10^9 CFU*
Lactobacillus acidophilus LA 201*
Lactobacillus plantarum LA 301*
Lactobacillus salivarius LA 302*
Bifidobacterium lactis LA 304*

Other ingrednients

Capsule (Vegetable source), Bulking Agent (Corn Starch), Maltodextrin, Anti-caking Agent (Magnesium Stearate).

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Bifidobacterium lactis


What is Bifidobacterium lactis?

Bifidobacterium lactis is a strain of probiotic bacteria capable of producing lactic acid which are classifed as gram-positive, rod-shaped bacteria. They populate naturally the end part of the ileum and large intestine. Their main function is to compete for nutrients and adhesion sites with pathogenic bacteria. Their properties can be thus desribed as antidiarrhoeal, regenerating the intestinal mucosa, helping the body take in more micronutrients and regulating intestinal peristalsis. 

This bacteria strain has also the ability to produce lactic acid from lactose or other substances which will hinder indirectly (by acidifying the environment) or directly (by killing bacteria) the growth and survival of such pathogenic bacteria as Salmonella or Helicobacter pylori.

The supplementation with probiotic strains helps restore healthy intestinal microflora which is nowadays disrupted by many negative environmental factors. 

Lactobacillus acidophilus


What is Lactobacillus acidophilus?

Lactobacillus acidophilus is a strain of rod-shaped bacteria with the ability to produce lactic acid which is beneficial to our health. These bacteria reside mainly in the intestinal mucosa. Like other probiotic strains, it can easily survive adverse conditions prevailing in specific sections of the digestive tract. As a result, it passes through the small intestine after oral administration and adheres to epithelial cells, forming small colonies. What is more, the strain was detected in the vagina, cervix and urethra. Owing to that, they can combat numerous diseases and maintain a healthy digestive and genitourinary system by competing with pathogenic microorganisms.

Apart from lactic acid production, the bacteria strain can synthesise also other organic acids which have the ability to inhibit the adhesion and proliferation of such pathogens as Escherichia coli, Staphylococcus aureus, Salmonella, Candida albicans, Shigella, Clostridium, Listeria and Helicobacter. By maintaining the normal pH in the intestines, it promotes the digestion of food and absorption of micro- and macronutrients.

It has been reported that this strain is capable of synthesising vitamin K. Consequently, it supports proper blood clotting and has a positive impact on bone structure.

By synthesising lactase, it can also promote lactose digestion, whereby treating unpleasant digestive ailments after consuming dairy products. It uses many bacteriocins for fighting pathogens, such as acidolin, acidophilin, lactobacillin, lactocin and many more. 

It is applied in medicine in the treatment of food poisoning, improving the body’s immunity and treating illnesses with antibiotics. It is a component of many prebiotic, probiotic and functional formulas and various nutritional supplements available at

Lactobacillus plantarum


What is Lactobacillus plantarum?

Lactobacillus plantarum is a strain of gram-positive, motionless, rod-shaped bacteria which ferment milk in the intestinal environment. These probotic strains are believed to be the most resistant to adverse conditions prevailing in different sections of the digestive tract. Apart from the small intestine, they were detected in the oral cavity and even vagina where they compete with pathogenic microorganisms, protecting the body from bacterial infections, viruses and mycoses. 

They affect the vitality of pathogens and synthesis of compounds beneficial to the health of, e.g. lactic acid and short-chain fatty acids. As a result, it normalises intestinal function, thereby ensuring proper digestion and nutrient absorption. By using the lactase enzyme, it has the ability to break down milk sugar which is the cause of many unpleasant digestive ailments in the majority of adults.

It is used in medicine for treating irritable bowel syndrome, problems with digestion and Crohn’s disease. It is used in supplementation as one of the components of complex probiotics available at

Lactobacillus salivarius


What is Lactobacillus salivarius?

Lactobacillus salivarius is a probiotic bacterium found mainly in the colon, small intestine and vagina, but it has been also detected in the oral cavity. It competes on populated areas with pathogens for a source of nutrients and adhesion site, hereby supporting other friendly bacteria strains in fighting pathogens. By adhering to the intestinal mucosa, it supports the intestinal barrier function. It has also a significant immunomodulatory action. It improves the balance between Th1 and Th1 helper cells in asthmatics, showing consequently an anti-inflammatory action. It inhibits the secretion of proinflammatory cytokines and supports the treatment of many skin allergies.

By producing lactic acid, bacteriocins and small amounts of hydrogen peroxide, it inhibits the growth or reduces the number of fungi of the genus Candida, E.coli, Salmonella ssp., Streptococcus pyogenes and Helicobacter pylori. Along with Bifidobacterium breve, it promotes the removal of Streptococcus mutans in the oral cavity which is responsible for tooth decay, dental plaque formation and mouth ulcers.

Promising results have been also observed in reducing pain. It results from the fact that Lactobacillus salivarius has the ability to induce the expression of receptors associated with pain relief, in particular OPRM1 in the intestines. What is more, it influences the brain-gut connection, hereby improving gut health after taking antibiotics or damaged by pathogens. As a result, it can contribute to improving cognitive functions, reducing depressive states and anxiety. It has also shown a beneficial impact on the cardiovascular system by reducing cholesterol levels and blood pressure.

Lactobacillus salivarius is found mainly in complex probiotic or symbiotic formulas available at

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