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Jarrow Formulas DIM + CDG is a dietary supplement combining two unique compounds – diindolylmethane (DIM) and calcium-D-Glucarate (CDG). Complex formula ensures twofold effect – it supports estrogen and testosterone balance and additionally it facilitates the process of detoxifying the organism.
The product is recommended in order to improve hormonal balance. It fights the symptoms of estrogen dominance both in women and men. It supports the breakdown of the so-called “bad” forms of estrogen metabolites and supports liver in detoxification. It allows to efficiently remove dangerous xenoestrogens, xenobiotics and other toxic compounds from the organism. Many studies prove that the substances contained in the preparation lower the risk factors of developing hormone-dependent cancers.
Diindolylmethane (DIM)) is a metabolite of Indole-3-Carbinol (I3C) – a compound naturally occurring in cruciferous vegetables, such as broccoli, cabbage or cauliflower. I3C, after getting into the organism is subjected to the activity of myrosinase, an enzyme, which catalyzes its breakdown to DIM.
DIM demonstrates a range of pro-health properties. First of all, both in men and women, it positively influences metabolism of hormones and modulates their level in the organism. Additionally, it has antioxidant, anti-inflammatory and anticancer effect.
Calcium-D-Glucarate (CDG) – is a compound which is the combination of calcium and glucaric acid. In the organism it takes part in the process of glucuronidation, in which drug metabolites, carcinogens and other dangerous toxic substances are neutralized and removed from the system. Therefore, it is one of the most important compounds responsible for effective detoxification of the organism.
The improvement of estrogen metabolism
Estrogen metabolism is essential in preventing excessive level of these hormones in the organism. The fact, whether there are unbeneficial estrogen metabolites left in the organism is dependent on the efficiency of this process.
DIM improves estrogen metabolism by changing estrogen metabolite breakdown. By influencing the enzymes taking part in estrogen metabolism, it increases the production of 2-hydroxyestradiol and 2-hydroxyestrone, limiting at the same time the production of 4-hydroxyestrone and 16-hydroxyestradiol. 2-hydroxyestradiol and 2-hydroxyestrone protect the organism and constitute the so-called “good” estrogens, while 4-hydroxyestrone and 16-hydroxyestradiol have carcinogenic effect and are blamed for the majority of harmful effects of estrogen dominance.
CDG complements the activity of DIM. Low level of CDG in the organism correlates with higher level of beta-glucuronidase. High concentration of beta-glucuronidase increases the number of estrogen receptors. This means that estrogen metabolites, which could be eliminated from the organism, bind with a larger number of receptors and stay in the organism, disturbing hormonal balance. Supplementing CDG reverses this unbeneficial process. It has been proven in one of the studies that CGD was able to lower the number of estrogen receptors by 48%, thanks to which the level of estrogens in blood serum was decreased by 23%.
Facilitating detoxification process
CDG is one of the most important compounds that take part in the process of glucuronidation. The reactions of glucuronidation allow to increase the polarity of dangerous toxic substances, drug metabolites and remnants of hormone breakdown, thanks to which they can be easily bound and eliminated from the organism with urine and bile.
Glucuronidation leads to the total incapacitation or elimination of dangerous chemical compounds in the system. Its pace depends on, among others, the presence of β-glucuronidase enzyme. Increased level of β-glucuronidase inhibits the process of detoxification and correlates with many various diseases, especially cancer. CDG inhibits the activity of β-glucuronidase, thanks to which it facilitates the main detoxification pathway of the organism.
Many clinical studies have confirmed anticancer and chemopreventive properties of DIM and CDG. Thanks to facilitating the metabolism of estrogens and effective detoxification of the organism, the main causes of hormone-dependent cancers are eliminated (breast cancer, endometrial cancer, cervical cancer and prostate cancer).
DIM is also effective, when the disease has already developed – it slows down its progression and limits the risk of metastatases. It promotes apoptosis (programmed cell death) in cancer cells. It inhibits angiogenesis (the creation of blood vessels in existing cancer cells), thanks to which it allows to disconnect the tumor from nutrients essential for its growth.
Benefits for women
The excess of estrogens in the female organism is responsible, among others, for mood swings, skin problems, difficulties in maintaining proper body mass or lower libido. By restoring hormonal balance, DIM decreases all unbeneficial symptoms of estrogen dominance.
DIM may be used in the treatment of intensive symptoms of premenstrual syndrome (PMS). It also constitutes a safe alternative to hormonal replacement therapy used among women in menopause.
The disorders of hormonal balance make women prone to cancer – especially breast cancer, endometrial cancer and cervical cancer. Thanks to the ability to balance out the level of “good” and “bad” estrogens, DIM lowers this risk and by the same token is a valuable element of prophylaxis of hormone-dependent carcinogenic diseases.
Benefits for men
DIM is more and more widely used by men in order to maintain the balance between the level of testosterone and estrogen. A natural consequence of the passing time is the drop in testosterone level, which may lead to estrogen domination in the organism. Research shows that men with slight estrogen surplus are three times more prone to strokes, the development of coronary heart disease or prostate cancer. Moreover, estrogen domination is often related to gynecomastia and is conducive to storing fatty tissue, which inhibits our work on the dreamed silhouette.
DIM not only facilitates estrogen metabolism and prevents unbeneficial symptoms of estrogen domination, but it also may increase the level of testosterone in blood. This compound works as aromatase inhibitor – an enzyme responsible for transforming testosterone in estrogen. By inhibiting aromatase, it naturally makes the larger pool of free testosterone stay in the organism.
Many bodybuilders, who use natural or synthetic testosterone boosters implement DIM to their supplementation in order to inhibit the conversion of testosterone surplus to estrogens and prevent possible side-effects.
DIM is also used in order to prevent benign prostatic hyperplasia (BPH). It also reduces unfavorable symptoms (urinary incontinence, difficulties in urination, pain symptoms) in already sick men.
Summing up, DIM + CDG is a supplement suitable both for women and men. It combines two perfectly researched compounds with scientifically proven effectiveness. By using one preparation, it is possible to take care about proper hormonal balance and effective detoxification of the organism and additionally take care about lowering the risk of developing hormone-dependent cancers.
1 capsule a day during a meal.
Dietary supplement complementary to a diet for athletes. It can not be used as an alternative or substitute for a varied diet.
It can not be used as an alternative or substitute for a varied diet.
Do not exceed the recommended daily intake.
Best before: the expiry date on the bottom or side of the packaging (min. 3
months of shelf-life).
Should not be administered to nursing mothers and pregnant women.
Keep in dry and dark place, at room temperature not exceeding 25°C, and away
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|per 1 capsule||amount||%DV|
|calcium (as calcium D-glucarate)||30 mg||4%|
|calcium D-Glucarate (CDG)||250 mg||*|
|BioResponse DIM (A patented complex containing ≥25% diindolylmethane) (starch, diindolylmethane, Vitamin E [as d-alpha tocopheryl succinate (tocophersolan)], soy phosphatidylcholine, silica)||100 mg||*|
Cellulose, Silicon Dioxide And Magnesium Stearate (Vegetable Source), Hydroxypropylmethylcellulose (Capsule)
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