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Apollo’s Hegemony Agmatine is a dietary supplement containing 500 mg of agmatine sulphate per capsule. The preparation improves blood flow in muscles and enhances their regeneration, helps to restore sensitivity to stimulants, and has a beneficial effect on the efficiency of the nervous system (nootropic, neuroprotective, and antidepressant properties).
Agmatine is a polyamine, an L-arginine metabolite formed as a result of decarboxylation. Agmatine occurs commonly in many food products but its content in food is much lower than standard doses with biological activity, which is why it is becoming a more and more common component of dietary supplements, where it is found in the form of agmatine sulphate.
The most popular application of agmatine is stimulating the phenomenon of the so-called muscle pump, because of which it enjoys great popularity among physically active people. However, agmatine exhibits a much wider range of activity, it goes far beyond just stimulating nitric oxide.
Agmatine – endogenous neuromodulator
For a relatively short time, agmatine has been named one of endogenous neuromodulators or neurotransmitters, believed to have a significant role in supporting the treatment of many central nervous system (CNS) disorders. Thanks to its neuromodulatory and neuroprotective properties, agmatine can prove of great help in case of such ailments as depression, anxiety disorders, morphine addiction, Parkinson’s disease, epilepsy, or brain trauma.
According to scientific research, agmatine can prove a promising agent in terms of alleviating neuropathic pain (it works in synergy with some analgesics, such as morphine – it is able to stimulate anxiolytic activity), supporting drug addiction treatment, preventing strokes, and supporting cognitive functions. Agmatine works in synergy with many antidepressants as well, for example bupropion.
Antidepressant effect of agmatine
Agmatine is stored in nerve cells, and then, as a result of their activation, it is released. To define the location of agmatine more exactly, it is present mainly in the areas involved in regulating anxiety, stress and depression.
It has been observed that aginine decarboxylase, the enzyme that allows the production of agmatine, increases in stressful conditions. It is believed that the process is the organism’s defensive response to stress.
Beneficial effect on brain function
Many scientific studies demonstrate that agmatine exhibits nootropic properties and is involved in learning and remembering processes. It has been shown that after oral administration, agmatine affects cognitive functions, which, in turn, suggests that it can cross the blood-brain barrier and reach the brain. Moreover, the half-life of agmatine in the circulatory system is much shorter than its half-life in the brain itself.
Agmatine also shows the ability to prevent excitotoxicity caused by glutamate and excessive NMDA receptor activation. Excitotoxicity is a pathological process involved in many disorders in the organism, for example: brain strokes, neurodegenerative diseases (multiple sclerosis, Alzheimer’s or Parkinson’s disease), hypoglycaemia.
Restoration of sensitivity to stimulants
Using agmatine can not only slow down the development of tolerance to analgesics and reduce drug or alcohol addiction. As it turns out, the substance can also prove of great help in case of growing resistance to stimulants. Thanks to its ability to antagonise NMDA receptors of the glutamatergic system, agmatine helps to increase the level of neurotransmitters (like catecholamines – noradrenaline and dopamine), whose reserves drop as a result of excessive excitability connected with regular supplementation with some stimulants, for example caffeine, DMAA, PEA. Agmatine slows down the development of tolerance to psychoactive substances, improves the regeneration of dopamine receptors, and helps to get through the difficult period of stimulant withdrawal.
Blood and oxygen flow improvement in tissues
By helping to increase nitric oxide synthesis, agmatine dilates blood vessels and improves blood flow in muscles, thanks to which it increases exercise capacity and endurance. The probable mechanism of that activity is connected with the fact that agmatine affects vascular endothelial cells. By permeating through blood vessels, agmatine molecules bind with receptors found in the membranes of vascular endothelium, in response to which cells produce nitric oxide.
To sum up, Apollo’s Hegemony Agmatine is a dietary supplement that, apart from its beneficial effect on exercise and regeneration capacities of the organism, also exhibits great potential in terms of treating neurological and neurodegenerative diseases. The preparation is designed not only for physically active people who wish to increase their nitric oxide synthesis, but also for those who struggle with increasing tolerance to stimulants or need support in the difficult period of stimulant withdrawal.
It is a good idea to take agmatine about 30 minutes before training, as that will allow an increase in nitric oxide levels in blood vessels and, therefore, a better muscle pump. An additional advantage of agmatine supplementation before workout is the fact that it can help to reduce tolerance to stimulants contained in, for example, pre-workout supplements. In order to increase the effect of the restoration of sensitivity to stimulants, it can prove useful to combine agmatine with huperzine A supplementation, as the substance can improve the desired effect as a non-invasive NMDA inhibitor.
Apollo’s Hegemony is a manufacturer of dietary supplements whose composition is based on the latest scientific research and experience. The company is constantly expanding its range of products and taking care that they are of top quality.
It offers formulations which have multiple effects on the body and those with more targeted effects – e.g. boosting alertness and focus, increasing the tolerance to stress, promoting peaceful sleep and maintaining the health of the liver and adrenal glands.
Dietary supplements by Apollo’s Hegemony are effective owing to carefully selected composition which comprises the most potent forms and their precise doses. What is more, herbal supplements contain standardised extracts.
All products of this brand comply with good manufacturing practices (GMP) and their ingredients are vegan and vegetarian friendly.
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|per portion (1 capsule)||amount||%DV|
|Agmatine sulfate||500 mg||-|
Microcrystalline cellulose, rice flour, gelatin (capsule shell).
The product has not been tested for substances banned by the World Anti-Doping Agency (WADA).
Agmatine sulfate is a compound of agmatine, and hence the substance resulting from the processing of arginine.
It meets the body's range of functions, including increases levels of nitric oxide responsible for vasodilation and thus improves blood circulation. It stimulates the release of growth hormone and testosterone. It increases the amount of nutrients delivered to the muscles, and normalizes blood glucose levels, thereby mimicking the operation characteristic of insulin; improves the functioning of the central nervous system; fights free radicals; reduces depot body fat, and also affects the metabolism of calcium, thus providing a better functioning of the heart, brain and muscles.
Dosage: 500-1500 mg, the best half an hour before training.
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