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Pure Labs NAC is a dietary supplement with 600 mg of N-acetyl cysteine (NAC) per serving. NAC is a precursor to glutathione – a multi-functional tripeptide which is one of the most important systemic antioxidants involved in the body’s detoxification processes for xenobiotics. First of all, the formula supports liver function and increases antioxidant capacity of this organ.
Glutathione is a tripeptide composed of cysteine, glycine and glutamic acid. It participates in the phase II of biotransformation of xenobiotics – so-called conjugation reactions. Thiol groups of glutathione react with many substances, leading to the formation of complexes that can be removed through the urine or bile. The highest concentrations of glutathione are observed in the liver and thus critical to cleansing the body of harmful substances and free radicals.
The conjugation of chemical compounds with glutathione is detoxifying. Glutathione combines with, among others, heterocyclic compounds, aliphatic unsaturated hydrocarbons or aliphatic and aromatic hydrocarbon epoxides.
Glutathione protects the liver against harmful effects of highly reactive substances which are products of cellular metabolism – free radicals, quinones and epoxides. A great amount of compounds conjugated with glutathione may lead to a decrease in its levels in the liver. This results in a reduction in antioxidant capacity of this organ and partial binding of toxic compounds.
Normal glutathione levels in the body are necessary for healthy liver function. NAC allows you to replenish glutathione levels, regenerate hepatocytes, protect against a harmful impact of some xenobiotic and improve liver enzyme levels. It is used, among others, in the treatment of nonalcoholic steatohepatitis which is caused by oxidative stress and lipid peroxidation processes.
A reduction in mitochondrial glutathione levels induces cell apoptosis. At low GSH levels, cardolipin is oxidised. Cardolipin is located in the internal cell membrane of this organelle and reduces its permeability. This leads to increased efficiency of cellular respiration processes. Cardiolipin oxidation is followed by the release of cytochrome c, a protein involved in the initiation of cell apoptosis.
As a strong antioxidant, glutathione inactivates reactive oxygen species and protects cell structure from their damaging effects. Glutathione takes part in the reduction of the oxidised form of vitamin C into ascorbate with proper antioxidant activity.
N-acetyl cysteine is used in toxicology as an effective antidote for some toxic chemical compounds. First of all, it is used in poisoning with paracetamol which is partly metabolised into very hepatotoxic N-acetyl-p-benzoquinone imine. Liver glutathione deficiency leads to hepatocellular necrosis. By replenishing glutathione levels, NAC helps bind completely and inactivate a harmful substance. Furthermore, NAC is used in poisoning with Amanita phalloides or some irritant gases.
N-acetyl cysteine may aid in the treatment of some psychiatric disorders. By boosting glutathione levels in the nervous system, NAC has an impact on glutamatergic transmission. NAC may relieve symptoms of depression, bipolar disorder and obsessive-compulsive disorder. This compound may be helpful in the therapy for schizophrenia and addictions.
To sum up, Pure Labs NAC is a dietary supplement recommended especially for individuals who take medicines or stimulants for a long time to protect and support liver function, strengthen the body’s immunity and help cleanse the body of toxins.
In order to increas glutathione activity and maximise detoxification processes, it is suggested to combine NAD supplements with those containing selenium. Selenium is a component of isoenzymes of glutathione peroxidase, protecting body cells against harmful oxidation by peroxides. In addition, this element helps detoxify the body by binding and removing heavy metals, e.g. mercury and lead.
PURE LABS NUTRITRION is a company offering a wide selection of diet and nutritional supplements. An important part of the offer are sports supplements, such as L-arginine, which is necessary to build muscles, a natural testosterone boosters and strength enhancing supplements. The company also produces other supplements, such as vitamin supplements and supplements supporting weight reduction.
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Cysteine belongs to the group of essential amino acids, synthesized by the body, involved in detoxification of the body. The combination of L-cysteine with glutamine and glycine is involved in the synthesis of glutathione (a powerful antioxidant) and the proteins, enzymes and co-enzymes. Present in the protein product, in smaller amounts in corn and peanuts. The source of the acquisition are also concentrates and whey protein isolates, and preparations containing mixtures of amino acids. Not in the form mono-preparations. It is a component of detoxification, supporting the work of the liver supplements and in supplements improving the cosmetics of the body, usually in the form of L-cystine (two connected cysteine particles) or in the form of NAC.
Dosage: the usual supplementation: 50-500 mg per day.
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