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Aliness Sodium Butyrate, 550 mg (Butyric acid 170 mg) is a diet supplement containing sodium butyrate, a source of butyric acid – a key energy material for the for epithelial cells of the small and large intestines. Sodium butyrate is a safe and well-tolerated compound with proven beneficial influence on the human gastrointestinal tract.
The formulation is contained in an innovative form of enteric microcapsules that protect butyric acid against the destructive effects of digestive enzymes in the upper part of the gastrointestinal tract and gradually release the substance at the target site – along the whole length of the intestines.
Sodium butyrate, i.e. butyric acid sodium salt, is a butyric acid source. Butyric (butane) acid is a saturated acid belonging to the group of short-chain fatty acids (SCFA), present in the large intestine. As a result of diseases and disorders of the gastrointestinal tract, the amount of butyric acid produced can be significantly reduced. A diet with a small amount of fiber also depletes endogenous butyrate resources.
SCFA are the basic source of energy for intestinal epithelial cells. Naturally, these compounds are formed in the large intestine due to anaerobic bacterial fermentation of dietary fiber. Along with butyric acid, acetic and propionic acid are also members of the SCFA. Of these compounds, butyrate is the most important source of energy for colonocytes. SCFA perform many functions in the digestive tract – they participate in the regulation of intestinal pH, improve the absorption of magnesium, calcium and iron, and beneficially influence the glucose metabolism. They promote the growth of useful intestinal bacterial flora, while inhibiting the growth of potentially pathogenic bacteria, including E. coli and Salmonella.
Sodium butyrate is a key ingredient in intestinal homeostasis. It is indispensable for optimal regeneration of intestinal epithelial cells. Sodium butyrate positively affects the minimization of hypersensitivity of intestinal receptors, regulation of intestinal neurotransmission and intestinal peristalsis.
Sodium butyrate is effective in reducing the symptoms associated with the Irritable Bowel Syndrome (IBS). Butyrate has a normalizing effect in functional bowel disorders, which include IBS. Numerous clinical studies have shown a decreased level of butyrate in people suffering from diarrheic form of IBS. While studying the effect of butyric acid on IBS symptoms, pain reduction was confirmed, including the pain after eating and during defecation. The best effects are visible during long-term use of butyrate. In studies, the effectiveness of supplementation was observed after a 3-month course. Sodium butyrate is a perfect complement to the pharmacological treatment of IBS – the studies showed an improvement in patients’ quality of life.
Butyric acid and other SFCA have an anti-inflammatory effect on the intestinal mucosa. These compounds, and to the biggest extend – butyrate, inhibit the activity of inflammatory mediators in intestinal epithelial cells, including IL-8. Supporting the regeneration, SFCA are helpful in the prevention of inflammatory bowel diseases. Sodium butyrate is recommended in the therapy of numerous inflammatory diseases of the digestive tract – inflammatory bowel diseases or diarrhea of various origins.
Butyric acid and other SFCA play an important role in the prevention of cancer formation process. These compounds, especially butyrate, have the ability to induce apoptosis of altered colonocytes, and because of that they can inhibit the tumor development at an early stage. Butyrate may inhibit the cell cycle of cancer cells. At the same time, butyric acid increases the proliferation of normal epithelial cells.
To sum up, Aliness Sodium Butyrate, 550 mg (Butyric acid 170 mg) is a diet supplement in the enteral form, ensuring the desired effects of butyric acid. This formulation is recommended in digestive ailments, in order to restore and regenerate the intestinal mucosa, supplementary in the irritable bowel syndrome, inflammatory diseases of the mucosa, diarrhea of various origins, after antibiotic therapy and in SCFA deficiency states.
It is best to take sodium butyrate with a meal. Supplementation with butyric acid should be accompanied by a balanced diet rich in probiotics and prebiotics. A diet rich in processed foods, simple sugars and insufficient fiber supply can adversely affect the number of endogenous SCFA.
Aliness is a Polish brand owned by Medicaline. The company has advanced development and research facilities and meets the demanding European Standards of Production and Storage based on the pharmaceutical standard GMP and HACCP. A team of experienced specialists supervises the quality of manufactured dietary supplements. The company uses only the highest quality certified raw materials, often occurring in patented forms.
Aliness cooperates with the research laboratories accredited by the Main Pharmaceutical Inspectorate - SGS Poland and J.S. Hamilton Poland S.A., and also with the National Institute of Medicines, responsible for quality and safety control in research and development. Many Aliness products have an ecological certificate, which is a guarantee of the lack of use of artificial fertilizers, pesticides and chemical plant protection products at all stages of the production of the raw material.
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Sodium butyrate is butyric acid sodium salt. It is much more stable than pure butyric acid, it does not have such a bad smell. In supplementation, it occurs in the form of a micro granulate, which is resistant to digestive enzymes of the upper gastrointestinal tract. The granules ensure the gradual release of sodium butyrate and distributing it over the entire length of the small and large intestine.
Sodium butyrate is used in disorders of the digestive tract. It has been shown to have a beneficial effect on intestinal colonocytes and is used by them as a source of energy. In addition, it promotes the increase in the amount and size of the intestinal villi and improves the integrity of the intestinal mucosa. It may also limit the production of proinflammatory cytokines and stimulate the production of compounds with antibacterial properties.
Dosing: according to the recommendation of a specialist. In prevention, the dose is usually from 150 to 300 mg of sodium butyrate per day.
Sodium is an important component of the intracellular fluids, and is a regulator of acid-base balance. Along with potassium affects the proper of growth and provides the proper functioning of muscles and nerves. The source of acquisition is table salt (NaCl) and bladderwrack, shellfish, bacon, beef, and of plant beets and carrots. People on salt-free diet should avoid, among others, spicy sauces and smoked meats and sausages.
Sodium deficiency is very rare, at heaving sweating after a long effort (e.g. in the marathon).
Excess sodium increases blood pressure (especially for the elderly), edema and increased thirst. Exceeding the daily dose of 14g a day can cause poisoning.
Salt (sodium chloride, or table salt), natural source of electrolytes (chlorine and potassium), regulating water and electrolyte and acid-base balance of the body, affecting the nervous system and blood pressure. Sodium is an essential element for the proper growth. The proper dose of salt prevents overheating of the body and solar stroke. It provides the proper functioning of muscles and nerves the body. Chlorine in combination with sodium, is involved in the digestive process and maintains acid-base balance in the body, as antitoxin removes toxic products of metabolism in the liver. Salt is a flavour component and preservative of many foods, nutritional supplements and mixtures of electrolytes, available at www.muscle-zone.pl
Dosage: no specific standards of consumption, used so as to provide sufficient amount of electrolytes to the body (sodium and chloride).
Butyric acid (butanoic acid) is an organic chemical compound belonging to the group of short-chain fatty acids (SCFA). In physiological conditions, it is produced in the large intestine by bacteria responsible for the fermentation of undigested carbohydrates.
Butyric acid positively affects the condition of the intestines. It is a source of energy for intestinal epithelial cells (colonocytes) – it stimulates their growth and differentiation; helps to maintain the integrity of the intestinal epithelium and stimulates the production of mucus in the intestinal mucosa. In addition, it promotes a reduction in the level of proinflammatory cytokines in the gastrointestinal tract.
Due to the characteristic and very unpleasant smell as well as the low durability, pure butyric acid is rarely used. Instead, for therapeutic purposes, salts of butyric acid (most commonly sodium butyrate) and its analogs (e.g., glycerol tri-butyrate, arginine butyrate) are used.
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