• Increases the number of mitochondrions in muscle
• Regenerates the articular cartilage
• Reduces inflammations of joints
• Has a strong anti-depressant properties
• Provides methyl groups
• Protects the liver against toxins
• Helps to burn fat
• Improves an insulin sensitivity
• Increases the natural production of testosterone

Doctor’s Best SAMe 400 Double Strength is a dietary supplement containing in its a scientifically proven, effective dose of high-quality S-adenosylmethionine – metabolically active form of the amino acid methionine.

Methionine is an exogenous amino acid, what means that it is not synthesized in the organism and must be supplied with the food. It participates in metabolic reactions and methylation to provide a sulfur group. Methionine and cysteine are the only amino acids containing sulfur. Methionine is necessary for the synthesis of proteins – it is the first amino acid being linked during the polypeptide chain building, therefore it is a very important ingredient to the processes associated with an increase of muscle mass.

S-adenosylmethionine (SAM, SAM-e, AdoMet) is a provider of methyl groups, which are transmitted to the amino compounds with the participation of enzymes – methyltransferase. Moving methyl groups by SAM is of great importance, among others, for gene activity and DNA synthesis. It participates, among others, in the biosynthesis of a number of hormones and neurotransmitters affecting mood, such as adrenaline. Although it plays different roles throughout the whole organism, most SAM is produced and used in the liver. Synthesized from ATP and methionine with the participation of the enzyme methionine adenosyltransferase.

Mitochondrions: Studies have shown that SAM increases the content of mitochondrions in muscles, which results in the intensity of the energy conversion and contributes to a higher strength. In turn, the increased production of energy leads to a reduction in body fat and an increase in insulin sensitivity (good news for diabetics).

Joints: SAM plays the important role in the regeneration of joints – providing methyl groups involved in the synthesis of cartilage while inhibiting the production of degenerating factors. All this makes it is an excellent prevention against osteoarthritis – a degenerative disease of the joints. Many SAM studies have been carried out so far regarding its use in both osteoarthritis and rheumatoid joints inflammations. In all the studies a remarkable therapeutic efficacy has been provd, and no side effects have been observed! SAM showed the same analgesic effect as non-steroid anti-inflammatory drugs, including popular Naproxen, further improving the performance of joint functionality.

Testosterone: Another unusual feature of the SAM is na activation of a pathway of signal LH – a hormone stimulating testes to produce testosterone. This can be recognized in such a way that the molecule LH combines strongly to its receptor, what results in a stronger signal transmitted to the Leydig’s cells. This occurs due to the increased production of cAMP – cyclic AMP, which plays the role of a transmitter of signals between the activated receptor and special proteins, which affect a specific number of vital processes in the cell and the activity of various genes. Leydig’s cells, in turn, in response to stronger stimulation by the signal, they produce more testosterone – up to 38%.

Depression: SAM participates in a number of important biochemical reactions, including those that affect the central nervous system (CNS), where it play the role as a donor of methyl groups. It shows a strong antidepressant activity, although the exact mechanism of action has not yet been fully recognized. However, it is believed that the improvement of the methylation in the CNS leads to increased level of the neurotransmitters: serotonin, dopamine and norepinephrine.

Liver: SAM deficiency over several weeks resulted in the progressive hepatic steatosis, leading to steatohepatitis, which is considered to be a risk factor for cirrhosis and liver cancer. SAM participates in the synthesis of glutathione – a powerful antioxidant playing roles related to cleaning the organism of harmful substances such as nitrogen compounds and chlorine-derivative toxins. In clinical trials, SAM showed therapeutic efficacy in enhancing the survival of patients with cirrhosis of the liver, waiting for transplantation.

A dietary supplement Doctor's Best SAMe 400 Double Strength has a comprehensive perpose starting from widely health benefits, through use of the purpose of improving the mental and physical capacity, ending on the use for therapeutic purposes. It is recommended especially to endurance athletes to increase strength and improve the level of endogenous testosterone. It is also recommended to people with osteoarthritis and rheumatoid arthritis. People prone to depression or depressed mood and those that expose the liver to contact with a large amount of toxins (drugs, alcohol, harmful food) they should take the formulation into consideration as part of prevention and health improvement.