• The activity independent of the MTHFR gene mutation
• Supports the nervous system functions
• Safe methylated form of folates
• The proper metabolism of homocysteine
• Supports normal pregnancy development
• Prevention of cardiovascular diseases
• Regulation of methylation
• Prevention of anaemia

NOW FOODS Methyl Folate is a dietary supplement containing the latest 4th generation folate, Quatrefolic®, which made up of 5-methyltetra-hydrofolate and glucosamine salt. The 4th generation folates are characterised by high activity and absorption. One capsule provides 1,000 mcg of folates.

Methyltetra-hydrofolate is a biologically active, methylated form of folate. Folates are involved in biochemical reactions, in which they play a role of coenzymes. They are a source of one-carbon residues, needed for the proper synthesis of DNA, proteins and myelin sheaths as well as for the transformations of amino acids. Folates are particularly needed in the cells which undergo intensive divisions, i.a. in bone marrow cells or fetal tissues.

Folates reduce homocysteine levels. Homocysteine is a sulphur amino acids, whose high blood level increases the risk of cardiovascular diseases, including coronary heart disease. It also promotes the development of mental disorders. Folates are necessary for remethylation of homocysteine to methionine, resulting in reducing homocysteine levels. Numerous studies demonstrate inverse correlation between the levels of folates and homocysteine in blood.

Folates support the balance in the nervous system. Too high homocysteine level promotes the development of mental disorders and neurodegenerative diseases. Impaired folate metabolism can activate neurotoxic and apoptotic processes. It is also suggested that folate deficiencies accelerate ageing of neurons and impair synthesis of particular neuromediators. Folate deficiencies are often observed in case of particular mental disorders, such as endogenous depression, psychosis and insomnia.

The complex folate sources support the proper pregnancy and child development. The proper folate supply is an essential factor in the prevention of congenital malformations, including serious neural tube defect. These defects are unfortunately still quite often. According to experts’ recommendations, during preconception and pregnancy, women should supplement folates in form of folic acid. You should not give up on using folic acid during pregnancy, but it is worth to supplement also an active folate, which will complement the folate levels faster and effectively support folic acid action.

Folates are necessary for the proper blood formation. Because of the important role in the DNA synthesis, folates and vitamin B12 are necessary for the proper production of erythroblast nuclei. Deficiency of these compounds results in production of abnormal megaloblasts, which are then transformed to enlarged and short-lived megalocytes instead of erythrocytes. This results in development of megaloblastic anaemia.