• Complex of the most bioavailable vitamin B12 and folinic acid
• Syngergistic effects for complex methylation support
• Promotes metabolism at the cellular level
• Provides enzymes for many reactions in the body
• Prevents atherosclerotic plaque formation
• Improves body energy mechanisms

Seeking Health Hydroxo B12 with Folinic Acid is a supplement with two compounds which act synergistically in regulating methylation: vitamin B12 in the form of hydroxocobalamin and folinic acid. They support energy metabolism of every person with increased physical load and support also efficient functioning of the cardiovascular system.

Vitamin B12 – contained in the supplement as hydroxocobalamin. It ensures much higher absorption than the popular form cyanocobalamin. Studies indicate that hydroxocobalamin is the most bioavailable non-methylated form of vitamin B12. In the body, it functions as an active enzyme in numerous reactions affecting energy mechanisms.

Folic acid – also belongs to B vitamins, found under the number 9. It is vital to proper gene expression, regulates the development of neural tube in the foetus and neurons in adults. It is shown to affect significantly the mood and activity of neurotransmitters. More and more often high doses of folic acid are suggested as an alternative for strong psychiatric medications.

Folic acid vs. folinic acid
Although both names sound similar, and metabolically speaking, both acids are on the same pathway, there is a significant difference between them when it comes to supplementation.

Folinic acid, which is a common name for 5-formyltetrahydrofolate, is one of the two metabolically active forms of folic acid. For many years, folic acid was supplemented with the thought that it will easily enter the pathway of its transformations and convert to its bioactive derivatives. Meanwhile, more and more research suggests that the tendency for folic acid metabolism disorders is increasing. It is estimated that over half of society may have problems with synthesising the enzymes necessary for dealing with the crucial compound.

That is why it is much more beneficial to supplement the metabolically active forms of folic acid, that is folinic acid and 5-methyltetrahydrofolate. What is more, recent research demonstrates that supplementation of ordinary folic acid can be harmful for the organism, accelerate the development of cancer, and have a negative effect on foetal development.

Complex methylation support
Even though both vitamin B12 and folinic acid demonstrate many autonomous properties in the body, they have been used and selected in ratio maximising their synergistic action on improving methylation. It is a process comprising a range of reactions determining bioavaility of nutrients. Its disorders lead to impairment of all metabolic functions of the body, especially affecting energy mechanisms.

The role of vitamin B12 and folinic acid in homocysteine methylation
Cobalamin is a coenzyme of two reactions in the methylation pathway: the conversion of homocysteine into methionine and methylmalonyl-CoA intosuccinyl-CoA. The main task of the supplement is to improve the first one of these reactions. The formula provides the body with hydroxocobalamin, easily converted into the methylated vitamin B12 which is an active enzyme stimulating the production of H4-folate from 5-methyl-H4-folate. 5-methyl-H4-folate (otherwise known as levomefolic acid) is a biologically active form of folic acid. Consequently, the formula supports comprehensively this phase of methylation.

The impact of methylation on metabolic homeostasis
The conversion of homocysteine has a significant role in cellular metabolism. Its disorders lead to impairment of the whole methylation process which entails disorders in other regulatory mechanisms of the body. It affects especially body energy balance because methylation products are intermediate substrates in the Krebs cycle – the basic energy mechanism of the human body.

Hyperhomocysteinaemia and the health of the cardiovascular system.
Disorders of homocysteine methylation will also cause its elevated concentration in the blood where it degenerates the blood vessel bed. Hyperhomocysteinaemia is associated with damages to endothelium of blood vessels. Because of that, it is identified as the primary cause of developing an atherosclerotic plaque.

To sum up, Hydroxo B12 with Folinic Acid is a complex support for the basic reaction in the methylation process. It ensures efficient functioning of body energy balance and healthy cardiovascular system. The supplementation with this formula should be considered by hard-training athletes as well as office workers – studies demostrate that mental stressors show the same ability to impair methylation as physical effort.