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Vitamin B6 belongs to the group of water-soluble vitamins. It includes several pyridine derivatives that participate in many extremely important biochemical reactions in the body. These reactions relate mainly to the metabolism of neurotransmitters (including serotonin), amino acids, lipids and carbohydrates. Such a versatile role of vitamin B6 makes it an irreplaceable and essential ingredient for the proper functioning of the body.
Why the coenzyme form?
Compounds with vitamin B6 activity function as coenzymes, which are compounds capable of binding with appropriate enzymes and their activation, allowing a given biochemical reaction to occur. The most popular form of vitamin B6 - pyridoxine hydrochloride, has to undergo changes in the liver to reach its active coenzyme form. This suggests that supplementation of this vitamin in the form of P-5-P allows direct delivery of the active substance bypassing the liver.
Lowering the homocysteine level
Homocysteine is a sulfuric amino acid whose increased concentration in the body (hyperhomocysteinemia) is associated with an increased risk of cardiovascular disease, as confirmed by many clinical studies. Homocysteine can induce oxidative stress and inflammation and initiate oxidation processes of LDL lipoproteins - so-called bad cholesterol. It also shows pro-thrombotic activity and contributes to the development of neurodegenerative diseases, including dementia.
Vitamin B6 in its active form is a coenzyme for the enzyme cystathionine β-synthase, which catalyzes the reaction leading to a decrease in the homocysteine level. It is believed that under normal conditions this process is responsible for the metabolism of about 50% of this amino acid.
Prevention of anemia
Vitamin B6 is a coenzyme for the enzyme δ-aminolevulinic acid synthase, which is necessary for the synthesis of heme - a component of hemoglobin, which gives the blood a red colour. Therefore, vitamin B6 is necessary for normal processes of hematopoiesis, and its deficiency leads to the development of macrocytic (non-pigmented) anemia.
Improving cognitive skills and mood
Vitamin B6 multidirectionally affects the proper functioning of the nervous system. As already mentioned, it is necessary for the synthesis of some neurotransmitters, including serotonin, colloquially called the happiness hormone. Due to the participation in the carbohydrate metabolism, this vitamin supports the optimal delivery of glucose, and thus the nutrition of cells of the nervous system. Deficiency of vitamin B6 contributes to the faster aging of neurons, it can manifest as a deterioration of mood, slowing mental performance and difficulties in falling asleep.
In conclusion, Aliness Vitamin B6 (P-5-P) is a preparation aimed at supplementing vitamin B6 deficiencies, recommended especially to people who lead a stressful lifestyle, perform mental work, and want to support cardiovascular health and proper metabolism of nutrients.
One of the factors that affect the body's need for vitamin B6 is the amount of protein in the diet. For high-protein diets it is recommended to increase its supply. Demand for this vitamin is also increased by taking oral hormonal contraception and stress.
Vitamin B6 improves the absorption of magnesium, therefore, in the case of supplementation of this element, it is worth taking both preparations at the same time.
Aliness is a Polish brand owned by Medicaline. The company has advanced development and research facilities and meets the demanding European Standards of Production and Storage based on the pharmaceutical standard GMP and HACCP. A team of experienced specialists supervises the quality of manufactured dietary supplements. The company uses only the highest quality certified raw materials, often occurring in patented forms.
Aliness cooperates with the research laboratories accredited by the Main Pharmaceutical Inspectorate - SGS Poland and J.S. Hamilton Poland S.A., and also with the National Institute of Medicines, responsible for quality and safety control in research and development. Many Aliness products have an ecological certificate, which is a guarantee of the lack of use of artificial fertilizers, pesticides and chemical plant protection products at all stages of the production of the raw material.
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Vitamin B6 (pyridoxine, pyridoxal, pyridoxamine) is soluble in the liquid. It participates in the metabolism of proteins, fats and carbohydrates. By reducing the amount of fat in the blood do not enable deposition of the body. It helps the absorption of magnesium and vitamin B12 (cobalamin). It works on the muscle antispasmodic and anti-inflammatory pain in the joints. It acts anti. It provides efficient operation of the brain. It increases energy increasing vigor of a man. The demand for vitamin B6 increases during pregnancy and breast-feeding infants. The natural product is: yeast, eggs, wheat germ, meat (liver), wheat bran, nuts, peanuts peanuts, soybeans. There is a hypothesis that can be synthesized by intestinal bacteria.
Deficiency of vitamin B6 causes abnormal metabolism of proteins, decrease in lymphocytes in the blood, causes a feeling of lethargy and fatigue intensifies.
Dosage: 1.5-2.5 mg daily (increased demand during pregnancy and lactation).
Pyridoxal 5-phosphate (P-5-P) - the form of vitamin B6, called coenzymatic, considered the best assimilable form of this vitamin by the human organism. This is related to direct metabolic activity of pyridoxal-5-phosphate in the human organism. It does not have to be subjected to biochemical transformations in the organism in order to be able to enter metabolic pathways as a biologically active ingredient.
Vitamin B6 is an incredibly important factor regulating the work of many processes in the organism due to its role in the organism as a coenzyme, essential for the activation of many important enzymes. Thanks to this, it regulates metabolism at many levels and its proper supply is conducive to maintaining homeostasis of the organism.
Another aspect of effectiveness of vitamin B6 is its influence on the normalization of emotional states. It is conducive to relaxation, facilitates falling asleep and falling in a deep, the most valuable sleep. Special influence on P5P on the psyche is proven in women before menstruation, as it demonstrates considerable ability to reduce the symptoms of the pre-menstrual syndrome.
Supplementation with vitamin B6 also demonstrates positive influence on the functions of the nervous system. It is conducive to the nourishment of neuronal tissues and optimizes the secretion of neurotransmitters, thanks to which it promotes nervous transmission and demonstrates neuroprotective properties. It was proven that vitamin B6 may decrease the risk of developing Parkinson’s disease.
Some sources also suggest the ability of pyridoxal 5-phosphate to reduce the risk of cancer. This effectiveness is noted especially in relation to breast cancer.
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