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Quaterfolic®, i.e. methyltetrahydrofolate (glucosamine salt of 5-methyltetrahydrofolic acid) is a highly available, methylated form of folate. In contrast to synthetic folic acid (vitamin B9), which must undergo complex biochemical transformations, methyltetrahydrofolate is a metabolically active form. It is characterized by high safety, bioavailability, and chemical stability.
Transformations of folic acid with the participation of DHFR and MTHFR
As already mentioned, folic acid (a synthetic form present in most of the dietary supplements) undergoes a complex metabolism, which results in the production of the target bioactive form – tetrahydrofolate. Folic acid, with the help of dihydrofolate reductase (DHFR) and methylenetetrahydrofolate reductase (MTHFR) enzymes, is first reduced to dihydrofolate and then to tetrahydrofolate.
MTHFR gene mutation and absorption of folic acid
MTHFR refers not only to the enzyme but also to the gene responsible for its formation. In case of MTHFR gene mutations, the functionality of the enzyme encoded by the gene is disturbed, so is the metabolism of folic acid. This results in a significant reduction in the bioavailability of this compound, which may be the cause of folate deficiency, with many health consequences. Unlike folic acid, methyltetrahydrofolate, i.e. active folate, does not need to be reduced by MTHFR.
Folates and the homocysteine level
Methyltetrahydrofolate is the source of one-carbon residues necessary in many metabolic processes, including in the transformation of amino acids. It is necessary for the remethylation of homocysteine to methionine, which results in lowering the homocysteine level in the body. Homocysteine is a sulfuric amino acid, whose elevated level promotes the occurrence of cardiovascular diseases, disorders of the nervous system, including Alzheimer's disease and cancer (especially colon cancer).
Protection against anemia
One of the symptoms of folate deficiency is megaloblastic anemia, characterized by the presence of megalocytes – enlarged erythrocytes with shorter survival time and a slower production rate. This is due to the participation of folates and vitamin B12 in the proper formation of erythroblast cell nuclei. Symptoms of this type of anemia include easy fatigability, decreased energy levels, difficulty with concentration, headaches, and impaired fertility.
Folates – essential for normal pregnancy
The appropriate supply of folates is essential for the proper course of pregnancy. Folates are needed for proper divisions of intensely dividing cells, which include fetal tissue. Therefore, this is why the demand for folates increases during pregnancy. It is recommended to supplement folates already in the preconception period, as well as during pregnancy and after birth.
It has been shown that folate deficiency in the diet of a pregnant woman increases the risk of congenital malformations of the fetus, such as neural tube defects. The best solution seems to be the combined supplementation of active folate and folic acid (do not give up folic acid). The inclusion of methylated folate in the supplementation will bring benefits in the form of faster saturation of the body and better digestibility.
Folates for the health of the nervous system
Folates are essential for the proper functioning of the nervous system. There is more and more data on their neuroprotective properties. They participate in the synthesis of neurotransmitters, including adrenaline, noradrenaline, and dopamine. Numerous epidemiological studies indicate that folate deficiency contributes to the development of diseases and disorders of the nervous system such as depression, accelerated aging of neurons, dementia or various types of neuropathy. This is due to elevated levels of homocysteine, accompanying folate deficiency.
In conclusion, Aliness Methylo Folian 5-MTHF is a dietary supplement aimed at ensuring adequate folate supply and supplementing their deficiencies. The product is recommended especially for those, whose diet is low in folates, in conditions of increased demand for folates, for pregnant women, and women trying for a child, in methylation disorders, and to lower homocysteine levels.
Besides the folates, B6 and B12 vitamins also participate in the metabolism of homocysteine. In addition, vitamin B12 interacts with folates in many other biochemical reactions.
For pregnant women and those planning pregnancy, daily supplementation of folic acid at a dose of 400 μg is recommended. A diet that should be rich in folic acid is also very important. Products rich in this ingredient include leafy vegetables (spinach, lettuce), sunflower, citrus fruits, and many more.
Aliness is a Polish brand owned by Medicaline. The company has advanced development and research facilities and meets the demanding European Standards of Production and Storage based on the pharmaceutical standard GMP and HACCP. A team of experienced specialists supervises the quality of manufactured dietary supplements. The company uses only the highest quality certified raw materials, often occurring in patented forms.
Aliness cooperates with the research laboratories accredited by the Main Pharmaceutical Inspectorate - SGS Poland and J.S. Hamilton Poland S.A., and also with the National Institute of Medicines, responsible for quality and safety control in research and development. Many Aliness products have an ecological certificate, which is a guarantee of the lack of use of artificial fertilizers, pesticides and chemical plant protection products at all stages of the production of the raw material.
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Salt (sodium chloride, or table salt), natural source of electrolytes (chlorine and potassium), regulating water and electrolyte and acid-base balance of the body, affecting the nervous system and blood pressure. Sodium is an essential element for the proper growth. The proper dose of salt prevents overheating of the body and solar stroke. It provides the proper functioning of muscles and nerves the body. Chlorine in combination with sodium, is involved in the digestive process and maintains acid-base balance in the body, as antitoxin removes toxic products of metabolism in the liver. Salt is a flavour component and preservative of many foods, nutritional supplements and mixtures of electrolytes, available at www.muscle-zone.pl
Dosage: no specific standards of consumption, used so as to provide sufficient amount of electrolytes to the body (sodium and chloride).
What is 5-methyltetrahydrofolate (5-MTHF)?
5-methyltetrahydrofolate (5-MTHF) is a methylated, biologically active form of folate. It is especially willingly used by people with folic acid metabolism disorders, especially by polymorphisms of the gene coding the production of methyltetrahydrofolate reductase. Using this form allows to skip narrow gorge created by this polymorphism and enjoy all effects induced by folates. It is also a good substitute for synthetic folic acid (pteroylmonoglutamic acid), which in clinical trials demonstrates the ability to increase the frequency of developing cancers.
Folates, also called vitamin B9 have a wide contribution to the development of the nervous system. They contribute to converting homocysteine to methionine and then to s-Adenosyl methionine, which is the main donor of methyl groups. Thanks to this, the condition of the circulatory system is increased, as the amount of pro-inflammatory homocysteine is decreased and the intensity of the production processes of creatine and neurotransmitter synthesis is higher, which is reflected in the reduction of fatigue and better psychological condition.
5-MTHF in mono-supplements and complex vitamin preparations may be found in the offer of muscle-zone.pl.
Vitamin B9 (folic acid, folacin, vitamin M) is part of a complex of B vitamins soluble in water. It takes part in the production of red blood cells, in cooperation with vitamin B12, preventing anaemia progression, its molecules are involved in catalysis of hematopoietic processes. Together with vitamins B6 and B12 it helps in the treatment of hyperhomocysteinemia. It eliminates disturbances in the gastrointestinal tract. It affects the proper functioning of the immune system. Necessary during pregnancy, because its deficiency causes neural tube defects in the fetus. The natural ingredient of yeast, eggs, liver, green vegetables and it is synthesized in the gastrointestinal tract by intestinal bacteria.
Dosage: The daily requirement is 0.1-0.2 mg.
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