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Pregnenolone 10mg loz. Pregnenolone 10mg loz.

Source Naturals Pregnenolone is a dietary supplement containing pregnenolone, which plays a role of the precursor in the biosynthesis of steroid hormones. Its endogenous conversion in the organism takes place on many pathways, depending on individual needs of the organism. Clinical studies carried out until now proved that pregnenolone may have influence on the increase of psychomotor abilities and reduction of fatigue in healthy people.

Pregnenolone is a steroid hormone, which is synthesized in mitochondria directly from cholesterol and it plays the role of the precursor for other hormones, i.e. progesterone and DHEA. The process of steroidogenesis is composed of many stages and requires the activity of  many enzymes, which transform subsequent metabolites to the final products, which are testosterone, estrogens, aldosterone and cortisol. Pregnenolone is produced with the participation of an enzymatic complex, in the composition of which there are: cytochrome P-450, NADPH and molecular oxygen.

Hormonal balance
Conversion of pregnenolone takes place on many pathways, dependent on the cellular requirements. Pregnenolone may be converted to DHEA, which in turn may undergo transformation into androgens (including testosterone), estrogens or other steroids. It may also be transformed into any other hormone, including progesterone, corticosterone and aldosterone. Since the organism may convert pregnenolone to other hormones, according to its needs, the supplementation may be used to amend balance disorders of some hormones, without the influence of the balance of other hormones It is a great advantage over steroid hormones, such as DHEA, which may cause the excess of estrogen and testosterone.

Influence on the organism
Due to a very wide scope of influence on the organism, pregnenolone is an exceptional substance. It is believed that as steroid precursor, it takes part in each biochemical mechanism, in which any steroid hormone is engaged. It means that it may have influence on memory, alertness, reaction to stress, female reproductive cycles, natural defense mechanisms of the organism, anabolism and also the functions of joints and tissues. With such a wide spectrum of effects, the potential to use pregnenolone may be unlimited.

The influence on sleep and the nervous system
Pregnenolone playing the functions of a neurosteroid is produced by glial cells of the brain and works in an extranuclear way. The synthesis of pregnenolone by glia takes place independently of its extracerebral sources coming from sex glands and adrenals. The application of pregnenolone to people causes sleep changes and increases the length of the phase NREM and spectral analysis of EEG during sleep indicated reduction of the strength of sigma brainwaves, the high activity of which may be indicative of damages or disorder of the structures of the central nervous system. Apart from this, it was also proven that the effect or pregnenolone influences inhibiting GABA receptors in brain cells, which may lead to increasing mental alertness and also it may stimulate NMDA receptors, which play a crucial role in regulating synapses, influencing at the same time memory and learning.

Anti-stress effect
During research on people, among whom excessive activity of stress was diagnosed, it was discovered that supplementation with pregnenolone demonstrates positive effect. It is believed that when people are in a stressful situation, pregnenolone influences the level of stress, affecting adrenal glands, which produce more steroid hormones. Moreover, decreased concentration of pregnanolone is observed in cerebral fluid of people suffering from endogenous and post-natal depression, which may result from the sudden drop of the level of progesterone and its metabolites.

Neuroprotective effect
It is known that pregnenolone protects neurons from the toxic effect of NMDA, demonstrates anticonvulsant effect and decreases the symptoms of brain ischemia in cerebral atherosclerosis and thanks to this it may effectively preventively protect from the effects of brain ischemia. Initial experimental reports indicate that neurosteroids, including pregnenolone, are synthesized in the central nervous system, they may influence the functions of glial cells, e.g. the synthesis of myelin proteins and in the future they may have therapeutic application in regeneration of damaged nerve fibers.

To sum up, Source Naturals Pregnenolone is an exceptional dietary supplement for men and women at all ages, which provides essential products for the synthesis of the key hormones. It helps to restore lost hormonal balance and it contributes to maintaining it. When used in appropriate doses, it may be a great alternative to other hormonal products, the application of which is burdened with the risk of side-effects. The supplementation is recommended in order to support the functions of adrenals, alleviate the consequences of stress and fatigue and to improve mental efficiency and sleep quality.  

UK Stock
Since 2005
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Pregnenolone 10mg loz. Pregnenolone 10mg loz. 10mg 60 loz.
Source Naturals
£ 8.39

Pregnenolone 10mg loz.

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Description
  • Has wide spectrum of effects
  • Plays a role of the precursor in the biosynthesis of steroids
  • Influences regulation of the hormonal system
  • Has antidepressant and anti-stress effect
  • Improves mental efficiency and memory
  • Increases psychomotor abilities
  • Demonstrates neuroprotective effect
  • Increases the level of energy and vitality
  • Decreases fatigue of the organism

Source Naturals Pregnenolone is a dietary supplement containing pregnenolone, which plays a role of the precursor in the biosynthesis of steroid hormones. Its endogenous conversion in the organism takes place on many pathways, depending on individual needs of the organism. Clinical studies carried out until now proved that pregnenolone may have influence on the increase of psychomotor abilities and reduction of fatigue in healthy people.

Pregnenolone is a steroid hormone, which is synthesized in mitochondria directly from cholesterol and it plays the role of the precursor for other hormones, i.e. progesterone and DHEA. The process of steroidogenesis is composed of many stages and requires the activity of  many enzymes, which transform subsequent metabolites to the final products, which are testosterone, estrogens, aldosterone and cortisol. Pregnenolone is produced with the participation of an enzymatic complex, in the composition of which there are: cytochrome P-450, NADPH and molecular oxygen.

Hormonal balance
Conversion of pregnenolone takes place on many pathways, dependent on the cellular requirements. Pregnenolone may be converted to DHEA, which in turn may undergo transformation into androgens (including testosterone), estrogens or other steroids. It may also be transformed into any other hormone, including progesterone, corticosterone and aldosterone. Since the organism may convert pregnenolone to other hormones, according to its needs, the supplementation may be used to amend balance disorders of some hormones, without the influence of the balance of other hormones It is a great advantage over steroid hormones, such as DHEA, which may cause the excess of estrogen and testosterone.

Influence on the organism
Due to a very wide scope of influence on the organism, pregnenolone is an exceptional substance. It is believed that as steroid precursor, it takes part in each biochemical mechanism, in which any steroid hormone is engaged. It means that it may have influence on memory, alertness, reaction to stress, female reproductive cycles, natural defense mechanisms of the organism, anabolism and also the functions of joints and tissues. With such a wide spectrum of effects, the potential to use pregnenolone may be unlimited.

The influence on sleep and the nervous system
Pregnenolone playing the functions of a neurosteroid is produced by glial cells of the brain and works in an extranuclear way. The synthesis of pregnenolone by glia takes place independently of its extracerebral sources coming from sex glands and adrenals. The application of pregnenolone to people causes sleep changes and increases the length of the phase NREM and spectral analysis of EEG during sleep indicated reduction of the strength of sigma brainwaves, the high activity of which may be indicative of damages or disorder of the structures of the central nervous system. Apart from this, it was also proven that the effect or pregnenolone influences inhibiting GABA receptors in brain cells, which may lead to increasing mental alertness and also it may stimulate NMDA receptors, which play a crucial role in regulating synapses, influencing at the same time memory and learning.

Anti-stress effect
During research on people, among whom excessive activity of stress was diagnosed, it was discovered that supplementation with pregnenolone demonstrates positive effect. It is believed that when people are in a stressful situation, pregnenolone influences the level of stress, affecting adrenal glands, which produce more steroid hormones. Moreover, decreased concentration of pregnanolone is observed in cerebral fluid of people suffering from endogenous and post-natal depression, which may result from the sudden drop of the level of progesterone and its metabolites.

Neuroprotective effect
It is known that pregnenolone protects neurons from the toxic effect of NMDA, demonstrates anticonvulsant effect and decreases the symptoms of brain ischemia in cerebral atherosclerosis and thanks to this it may effectively preventively protect from the effects of brain ischemia. Initial experimental reports indicate that neurosteroids, including pregnenolone, are synthesized in the central nervous system, they may influence the functions of glial cells, e.g. the synthesis of myelin proteins and in the future they may have therapeutic application in regeneration of damaged nerve fibers.

To sum up, Source Naturals Pregnenolone is an exceptional dietary supplement for men and women at all ages, which provides essential products for the synthesis of the key hormones. It helps to restore lost hormonal balance and it contributes to maintaining it. When used in appropriate doses, it may be a great alternative to other hormonal products, the application of which is burdened with the risk of side-effects. The supplementation is recommended in order to support the functions of adrenals, alleviate the consequences of stress and fatigue and to improve mental efficiency and sleep quality.  

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Composition

Composition

Container size: 60 lozengesDaily serving size: 1 lozengeServings per container: 60
per serving (1 lozenge)amount%RDA
Pregnenolone10 mg**

Other ingrednients

mannitol, sorbitol, hydroxypropyl methylcellulose, natural cherry flavor, modified cellulose gum, silica, stearic acid, and magnesium stearate.

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Pregnenolone

Information

Pregnenolone, called the “father of steroid hormones”, is a steroid synthesised from cholesterol as a result of the activity of the enzyme 20,22-desmolase found in mitochondria. Pregnenolone is a precursor to all steroid hormones, among others, progesterone, testosterone and estradiol, and mineralocorticoids and glucocorticoids.

Pregnenolone supplementation helps optimise hormonal balance. Unlike ready-made hormones, taking pregnenolone is “personalised” because it helps the body decide to which hormone it will be converted.

Pregnenolone administration is recommended both to women (during menopause and irregular periods) and middle-aged men (prevents drops in testosterone and libido). Pregnenolone supplementation may benefit also persons undertaking strenuous physical activity and struggling with “adrenal fatigue” (optimised cortisol levels) and the elderly in which levels of pregnenolone and hormones for which it is a precursor decrease (promyelinating properties and improvement in cognitive functions).

Our store offers pregnenolone in different package sizes, in the form of capsules, tablets and tasty lozenges.

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