NITROBOLON ENERGIZER contains large doses of the strongest energizers and boosters. The product helps improve nutrient, oxygen and blood supplies to muscles. It also considerably increases muscle efficiency during heavy-load workout.
NITROBOLON ENERGIZER contains large doses of the strongest energizers and boosters. The product helps improve nutrient, oxygen and blood supplies to muscles. It also considerably increases muscle efficiency during heavy-load workout.
The preparation will work well both as pre-workout, electrolyte liquid to sip during training and after-training regeneration supplement. In order to test your individual tolerance, during the first days of use it is recommended to use the reduced dose or at least the one recommended by the producer. Next, the dose may be adjusted to the individual needs. The product has strong stimulating effect and should not be taken before sleep.
Trec Nutrition is a company offering a wide choice of products for athletes. Products of this brand include carbohydrate-protein supplements, protein and energizers. The offer also includes amino acid supplements, creatine, HMB, fat burners, thermogenics, products supporting metabolism and speeding up the regeneration of joints.
|per portion (28 g)||amount||%RDA|
|SLOW ABSORPTION GLYCOGEN LOADER:Isomaltulose||7,33 g||*|
|PUMP AND ENERGIZED MATRIX:Creatine Monohydrate, Tri-Creatine Malate, Creatine Ethyl Ester, Kre-Alkalyn||6,92 g||*|
|ENERGY AND RECOVERY MATRIX:BCAA Complex (L-leucine, L-Isoleucine, L-Valine), Inosine, Glutamine Complex (L-Glutamine, N-Acetyl L-Glutamine)||5,81 g||*|
|NITRIX OXIDE AMPLIFIER:L-Arginine Alpha-Ketoglutarate, Di-Arginine Malate, Citrulline Malate||3,05 g||*|
|NEUROTROPIC MATRIX:Taurine, L-Tyrosine, Caffeine Anhydrous, Inositol||2,09 g||*|
|ELECTROLYTE REPLACEMENT MATRIX:|
|NATURAL VITAMIN B BOOSTER:|
|Pantothenic acid||2.04 mg||34%|
|Vitamin B2||0.48 mg||34%|
|Vitamin B6||0.48 mg||34%|
|Vitamin B1||0.37 mg||34%|
|Vitamin B12||2.55 µg||102%|
|Vitamin C||13.62 mg||17%|
acidity regulators (malic acid, citric acid), anti-caking salt (silicon dioxide), sweetener (sucralose), pigment (Quinoline yellow).
Glycogen loader is a carbohydrate complex, containing glucose and maltodextrin. Glucose (dextrose), monosaccharide - is an essential component of polysaccharides. It is used as a primary source of energy for the brain and red blood cells, it is quickly using or supplementing glycogen contained in muscles and liver, it is easily digestible (no etching). Maltodextrins have a bioavailability similar to that of glucose, and their molecular weight reduces their retention in the stomach. In the sports supplementation, Glycogen leader (carbohydrate complex) is used in the preparations supplementing energy levels after intense workout and during the biological body recovery.
Isomaltulose (Palatinose ™) - disaccharide built from simple sugars: glucose and fructose bound by a glycosidic bond 1,6-, with a low glycemic index (GI = 32), sustained energy release without causing excessive insulin growth and, consequently, without the increase in adipose tissue. It is fermented in the mouth causing dental caries. Natural sources of Isomaltulose are sugar cane and honey. In the sports supplementation (and dietetics) it is a component of carbohydrate and protein-carbohydrate supplements and pre- and post- workout stacks.
Dosage: As a dietary supplement and personal energy needs.
Creatine monohydrate is a popular and cheapest form of creatine used in sports supplementation in Poland. This is a molecule, in which are bound: creatine molecule with a molecule of water. It has a high bioavailability and tissue velocity saturation. Supports the exercise capacity (strength and endurance), accelerates muscle growth and regeneration after training exercise. Transport of creatine into the muscle cells is supported by the insulin hormone. For better effect of saturation of the tissues, a diet increasing the content of insulin in the body is indicated (carbohydrate and high protein diet) and supporting nutrients and supplements (Dietary carbohydrate and carbohydrate-protein, insulin ALA, d-pinitol or taurine). Creatine monohydrate is present in the form of mono-preparation supplements (capsules, powders, tablets) and multicomponent supplements (i.e. as a component of creatine stacks).
Dosage: depending on the form of supplement, the type of exercise and weight, normally are used one of the following models of creatine supplementation:
- cyclic supplementation : 5-10g per day in 1-3 portions during the day, 3-5g per dose. The length of the cycle for 4-8 weeks.
- cyclic supplementation with saturated phase: the first 5-7 days after 20-30g daily in 4-6 doses of 4-6g per serving, then the maintenance phase 2-10g per day in divided doses. The length of the cycle 4-8 weeks
- constant supplementation: 0,03-0,05g per kg of body weight for an extended period of time.
Creatine malate (tri-creatine malate, TCM, di-creatine malate) is a combination of one molecule of creatine and three (or two) of molecules of malic acid in the ionized form (malate) in one molecule. It has better solubility in liquids of creatine monohydrate. Malate is involved in energy conversion enhancing effect of creatine in this regard. With proper use of creatine malate, there is an increase in exercise capacity of the body (strength and endurance), acceleration - although slower than provide other compounds creatine for better quality - of increase in lean body mass, provides faster and better biological regeneration after exercise. To have a fast saturation of the muscles with creatine, products containing insulin should be used (carbohydrates and proteins) or insulin-mimetic (and the substances of similar ALA, D-pinitol, taurine). Creatine malate is available in the form of powders and capsules (mono-preparation supplements and creatine stacks), for purchase at muscle-zone.pl
Dosage: Usual recommendation in sports, depends on the form of supplement, the type of exercises and weight, uses one of the following creatine dosage models:
- cyclic supplementation: 5-10g per day in 1-3 portions during the day, 2-5g per dose. Cycle length approx. 4-12 weeks
- Constant supplementation: 0,03-0,05g per kg of body weight for an extended period of time.
Creatine ethyl ester (CEE) - Creatine with strong anabolic, catabolic and erogenic potential obtained through esterification, to obtain a higher bioavailability of creatine, and thus reducing the value of its individual doses. This results in lower weight gain than during use of special forms of creatine but better quality. Creatine ethyl ester is used in sports supplementation to obtain improvement in exercise capacity (strength and endurance) as mono-preparation supplement (in tablet form) or as a nutritional supplement (creatine stacks) and pre-workout supplements.
Kre-Alkalyn (buffered creatine monohydrate) is a patented formula of creatine, operating with better effect in smaller doses than other forms of creatine (creatine monohydrate). Use of kre-alkyn does not store water in the intercellular spaces, and muscle cells, its use provides full transportation (without support) into muscle cells. With its application, there are no digestive disorders.
Kre-alkalyn regularly used enhances the exercise capacity (strength and endurance) and accelerates the growth of lean body mass. Used after exercise affects the rapid renewal of cells and reduces the feeling of fatigue. It is often used by athletes, despite the higher price then other complexes of creatine. It is available as mono-preparation supplements (capsules, and powders) as well as the complementing of creatine stacks.
Dosage: as recommended by the manufacturer 2.5 - 5g / 24h.
BCAA are three essential amino acids having a side branched aliphatic chain (isoleucine, leucine, and valine) and a similar course of metabolic processes, occurring in the muscle tissue. In its natural form, they are found in high-protein animal foods (i.e. beef, milk proteins). BCAA have the anti-catabolic and anabolic potential. They support energy carriers during the energy crisis and affect the functioning of the nervous system (eliminate stress, reduce fatigue), hormone activity and kinases, which are responsible for the metabolism of proteins. In the sports supplementation they are used as supporting elements of exercise capacity (strength and endurance) and post-workout recovery; also as anti-catabolic and catalyst of anabolic changes. Taking BCAA after exercise almost immediately restores the levels of these amino acids in the blood (excluding liver) and supplies the muscle tissue. Leucine activates of mTOR kinases (starting anabolism of muscle proteins) and has the intensified effect with insulin, which acts on the PI3-kinase and protein kinase B. Branched amino acids chain BCAA, willingly used by strength, strength-endurance and endurance athletes, they are available in the form of single-component supplements, and advanced amino acid supplements, creatine, pre- and post- training stacks, and isotonic drinks.
Dosage: usually 1-2 grams of BCAA per 10 kg of body weight per day. Mainly before and after training.
Leucine is an essential amino acid, one of the three branched chain amino acids, ketogenic, its isomer is isoleucine. It affects the secretion of anabolic hormones (insulin, combined carbohydrates), acts on enzymes (mTOR) starting the process of muscle protein synthesis and controlling its course. Protein synthesis by leucine is affecting the development of bones, muscles and skin. It reduces the fat tissue. Without the availability of leucine, protein synthesis is impossible. It naturally occurs in animal products (such as eggs, meat, dairy and fish), plant origin, and as a post-training supplements, BCAA, EAA, no-boosters, creatine stacks, carbohydrate supplements. Ir is also in the form of mono-preparation supplements. It is one of the most important amino acids for the athlete's body, basically in every sports discipline.
Dosage: The demand is 5-10 g / 24h, dosage pre- and post-workout and in the morning after waking up.
Valine – is a branched essential amino acid, indispensible for the functioning of the nervous system (receiving of sensory information), involved in muscle protein synthesis and energy generation. Administration of additional doses of valine before exercise (or immediately after) has anti-catabolic effect, protecting the proteins and allowing them to rebuild. It is slightly stimulatory (delays symptoms of fatigue during workout), affecting the level and relations of neurotransmitters. It helps to protect the liver. It stimulates an increase in strength and muscle mass, participates in the reduction of body fat. BCAA, EAA, and other mixtures of amino acid supplementation, protein and protein supplements and carbohydrate-stacks, brings positive results in strength and endurance sports.
Valine deficiency can occur in case of increased energy needs of the body, as the result of stress and too much stress load.
Inosine (purine nucleoside) is formed in the body during the degradation of adenosine involving the ADA, its ingredients are: hypoxanthine and ribose. Participates in energy conversion in the body and reduces the level of lactic acid in the cells and muscle tissue , providing increase of the exercise capacity and an extension of an effort time. Scientific research confirmed neuroprotective and anti-virus action of inosine. In the sports supplementation used in the disciplines of endurance and strength as a dietary supplement and support of the effort. Available in the form of mono-preparation supplements and complex multicomponent supplements (including creatine stacks, nitrogen boosters).
Dosage: 1-2g a day, mainly before and after training.
Glutamine (L-glutamine) - endogenous amino acid building proteins, glutamic acid amide. In the human body it is responsible for the synthesis of proteins, acid-base balance and removing ammonia from the organism. With the shortage of energy taken from the muscle tissue, glutamine with alanine participate in the process of gluconeogenesis, and participate in the production of glucose substrate. Glutamine has a direct impact on the proper functioning of the digestive system and immune immunity of the organism. Participates in the synthesis of one of the most powerful antioxidant glutathione. It has anti-catabolic potential. It can be found naturally in foods of animal and vegetable origin, protein supplements. Used as mono- or multi-component amino acid supplements, and supplements improving biological recovery after exercise, often in combination with BCAA.
Dosage: 5-20 g per day (portioned during the day, and after training and waking up). The supplementation uses the minimum dose of 2-15g to 1 serving.
L-glutamine - amino acid building endogenous proteins, glutamic acid amide. In the human body it is responsible for the synthesis of proteins, acid-base balance and removing ammonia outside of the organism. With the shortage of energy taken from the muscle tissue, glutamine with alanine participate in the process of gluconeogenesis, and participate in the production of glucose substrate. L-glutamine has a direct impact on the proper functioning of the digestive system and immunity of the organism. Participates in the synthesis of one of the most powerful antioxidant - glutathione. It has anti-catabolic potential. It is found naturally in foods of animal and vegetable origin and high protein supplements. Used as mono-preparation or multi-component amino-acid supplements and supplements enhancing biological recovery after exercises, often in combination with BCAA.
Dosage: 5-20 g per day (portioned during the day, and after training and waking up). The minimum dose used in supplementation is 2-15g per 1 serving.
Arginine alpha-ketoglutarate (AAKG) is a salt glutaric acid and arginine. The presence of these compounds results in intensification of the operation of each of them. Arginine alpha-ketoglutarate improves the bioavailability by stimulating the decomposition to CO2 and H2O, which means that it becomes a precursor in the synthesis of nitric oxide. It has anti-catabolic properties enhancing anabolism. Enhances the functioning of the insulin hormone, insulin-mimetics IGF-1) and somatotropin growth hormone.
AAKG is part of the pre-workout supplements (improving muscle blood flow and increasing the exercise capacity (strength and endurance)), as well as improves the recovery process after training. Most often used to increase the synthesis of nitric oxide (supplements pre- and post-workout), increasing muscle blood flow and regeneration. Particularly valued by the representatives of power sports, power and strength sports and strength athletics. Used very often in the rehabilitation of sports injuries.
Arginine is an exogenous amino acid, it is a component of dietary proteins, not always synthesized in the human body in necessary quantity, so it is necessary to deliver it in the form of synthetics. It takes part in the biosynthesis agmatine, creatine and nitrogen oxides. The use of supplements containing arginine before workout increases the exercise capacity (strength, endurance). Used after considerable effort intensifies the transfer of energy and building compounds and intensifies the process of recovery. Used at bedtime in combination with lysine and ornithine enhances the synthesis of growth hormone. takes part in the intrasystemic synthesis of creatine. Arginine (as a precursor of ornithine) is involved in the urea cycle, increases the flow of blood in the circulatory system, increases sexual potency (in a short time after application). It affects the body's immunity preventing infections, and lowers blood pressure. In supplements – usually as alpha-ketoglutarate.
Citrulline Malate is formed by combining molecules of the citrulline amino acid and molecules of malic acid in one molecule, which has the chemical stability and is well soluble in liquids. Ionized malic acid has the ergogenic potential, providing a complementation to the citrulline potential of with new properties. It improves the exercise capacity and reduces the feeling of fatigue, and its supplementation is beneficial at any level of fitness. It affects the acid-base balance. It should be used by people who practice sports: strength, endurance and mixed strength-endurance. To achieve the best results, a dose of Citrulline Malate 6 g / 24h is recommended.
It is available as single-ingredient supplements and multi-component supplements (creatine stacks, no-boosters, amino acid supplements). It is used in the periodic, cyclic and constant supplementation.
Dosage: 3-8 g daily (in divided doses). The optimal dose to achieve beneficial results, proven experimentally, is 6 g / 24h.
Taurine – non-protein amino acid containing sulphur, which is synthesized in the body from methionine and cysteine, present in sufficient amount in human or animal body (in the brain, heart and skeletal), although in some cases must be supplemented. Significantly affects the calcium content in the cells and stabilizes the water and electrolyte balance and maintains acid-base balance. Takes part in the synthesis of bile acids. In the body acts as a neurotransmitter and neuromodulator. It is an insulin-mimetic improving insulin metabolism, responsible for transport of nutrients (such as amino acids, glucose, creatine) to the cells and muscle tissue. These properties determine that it is a valued mono-preparation supplement and valuable addition to creatine and amino acid supplements, recommended for psycho-pchysically active people and athletes and other competitive sportsmen in pre- and post-workout periods.
Dosage: 3 grams per day.
Tyrosine - endogenous amino acid (synthesized within the body), one of the 22 protein amino acids building. It occurs naturally in animal food products (eggs, dairy, meat). If the deficiency, it can be synthesized by hydroxylation of phenylalanine, capable of being converted to tyrosine in the liver. It is a precursor of neurotransmitters: dopamine (the group of catecholamines, participating in the processes occurring in the nervous system, causing muscle coordination and participates in the synthesis of many hormones) and noradrenaline (counteracting stress, stimulating the heart and circulatory system, and increasing glycogenolysis and lipolysis participating in the processes of energy transformations). Tyrosine is a precursor of thyroid hormones responsible for the rate of change in metabolic processes and pigment (melanin). In the supplementation, preparations containing tyrosine are used in programs reducing body fat (weight loss), improve mood and are stimulants.
Dosage: Customarily 500-2000 mg per day.
Caffeine (1,3,7-trimethylxanthine, 1-methylotheobromine) is a purine alkaloid occurring in the natural state in plants (Coffea arabica, Camelia sinensis, Paulinia cupana, Ilex paraguariensis), which acts as a natural pesticide, acting toxic to insects. Peculiar smell and taste also deters herbivores. Caffeine in the body inhibits the adenosine receptors in the brain, fighting fatigue and allowing for action activation. It has a beneficial effect on the metabolism of oxygen, which increases the exercise capacity (strength and endurance) and rapid post-workout recovery. In the sports supplementation, caffeine is used as a stimulant nervous system. It has the thermogenic potential and in combination with other substances (e.g. Polyphenols, both occurring in coffee beans, such as cocoa beans, tea leaves and mate) can effectively participate in the reduction of body fat. It is included in many dietary stimulants (creatine stacks, no-boosters, beverages). It is a component of fat burners. It is also in the form of mono-preparation supplements.
Dosage: 100-600 mg per day. Due to the long release of activity should not be used in the evening, before sleep.
Inositol is an organic compound from the group of B vitamins soluble in fluids, present in the natural or synthetic form, synthesized in plants, such as brewer's yeast, beans, grapefruit, cabbage, sprout of wheat, melons and animal (liver). Along with choline is included in the lecithin. It affects the cell nutrition of the central nervous system (brain) by reducing the level of LDL (bad cholesterol), this makes it applicable in treatment of Alzheimer's disease and atherosclerosis. It has a calming effect. There has been a beneficial effect of inositol on the skin and hair reported.
Sodium is an important component of the intracellular fluids, and is a regulator of acid-base balance. Along with potassium affects the proper of growth and provides the proper functioning of muscles and nerves. The source of acquisition is table salt (NaCl) and bladderwrack, shellfish, bacon, beef, and of plant beets and carrots. People on salt-free diet should avoid, among others, spicy sauces and smoked meats and sausages.
Sodium deficiency is very rare, at heaving sweating after a long effort (e.g. in the marathon).
Excess sodium increases blood pressure (especially for the elderly), edema and increased thirst. Exceeding the daily dose of 14g a day can cause poisoning.
Chlorine (chemical element from the group of halogens) - in the natural form of gas it is poisonous and water-soluble (until recently used as a disinfectant in the water supply system, now replaced by fluorination). It is chemically active element. It is used in the form of sodium chloride (NaCl) and potassium (KCl). It participates in the process of digestion and maintains acid-base balance in the body, removes toxic products of metabolism in the liver (antitoxin). Natural source of chlorine for the body is salt and bladderwrack.
Chlorine deficiency can occur due to excessive sweating, vomiting, causing digestive tract problems. It also causes loss of hair and teeth.
Excess chlorine, for example. Drink excessive amounts of chlorinated water, destroys bacterial flora and vitamin E.
Dosage: Daily dose should not exceed 15 grams.
Calcium (element chem. symbol Ca, atomic no. 20, the group of alkaline earth metals) is the basic building substance of bones and teeth, in which stored is 99% of the element, in the form of hydroxylapatite. When building bones and teeth, phosphorus is very important in the right proportion. It is a base-forming element and activator of many enzymes (ATPase) necessary to release the energy of ATP. It has a significant effect on blood clotting and regulates blood pressure and neuromuscular conductivity. Thanks to the reduced permeability of cell membranes, it soothes the symptoms of food allergies. Calcium is actively involved in the metabolism of iron interacts with vitamins A, C and D and phosphorus, magnesium. Natural source of calcium are animal products (dairy products, sardines, salmon, sprats eaten with bones) and plant products (nuts, soybeans, sunflower seeds). Absorption takes place in the small intestine (less in the colon), it has an effect on the level of lactose, insoluble fibre, organic acids, alkalinity (low pH). The best absorption have organic compounds (lactates, amino acid chelates etc.). Obstructing the absorption of calcium is caused by: phytic acid and oxalic acid as well as excess fat. Scientific studies have confirmed that the combination of calcium, magnesium, boron and vitamin D in dose 3 mg / 24h effectively prevent osteoporosis. Supplements on the market are both mono-preparation supplements (enriched with vitamin D3) and multi-component supplements, available at www.muscle-zone.pl.
Calcium deficiency disorders manifested in the construction of the bones (osteoporosis) and iron metabolism. The symptoms are: rickets, cramps and muscle tremor, osteoporosis.
Excess resulting from an overdose of calcium supplements containing vitamin D3 for children and adults overdose of calcium (hypercalcemia). Symptoms of hypercalcemia are: lack of appetite, vomiting and constipation.
The dosage administered in various publications are inconsistent: 800 - 1000 mg / 24 h (100 - 500 mg / 24h)
Potassium and sodium regulate the body's water resources, ensuring normal heart rhythm. Maintaining the proper level of potassium provides the proper oxidation of the brain, lowers blood pressure, increases the permeability of cell membranes (as an antagonist of calcium). It is a base-forming element. It is widely used in sports diet before and after training in the form of supplements, nutrients, vitamin-mineral preparations and minerals, concentrates and ready, isotonic and hypertonic beverages. Natural sources of acquisition of potassium are: vegetable products (bananas, citrus fruits, melons, mint leaves, green vegetables, potatoes) and animal products (sea fish, meat). Potassium is present in the form of organic compounds: citric acids, and fumarates gluconates and inorganic (chlorides, sulfates, oxides and carbonates).
Potassium deficiency (hypokalemia): excessive tiredness, headaches and irritability, problems with sleeping, muscle cramps, constipation. Potassium levels may drop sharply in the event of a reduction in blood sugar levels, prolonged starvation, severe diarrhea. They can occur when too much of strong coffee is consumed, with alcohol abuse and when eating too much sweets.
The excess of potassium (hyperkalemia) is often the cause of depression, hypotension, tingling in the extremities.
Magnesium (element from the group of alkaline earth metals, atomic no. 12, a chemical symbol - Mg), one of the most important health microelements, participates in the synthesis process of the disintegration of high energy compounds and processes of transformation of hydrocarbons and fats. It affects the dilation of blood vessels and lower blood pressure, prevents hypercoagulable state. Shortages affect cardiac arrhythmias, malignant muscle cramps, insomnia and anxiety. It is a component of many dietary supplements and found in foods such as whole grain bread, legumes, buckwheat, rice, fish, meat, as well as chocolate, cocoa and nuts.
Dosage of 100 - 500 mg / day
Vitamin B6 (pyridoxine, pyridoxal, pyridoxamine) is soluble in the liquid. It participates in the metabolism of proteins, fats and carbohydrates. By reducing the amount of fat in the blood do not enable deposition of the body. It helps the absorption of magnesium and vitamin B12 (cobalamin). It works on the muscle antispasmodic and anti-inflammatory pain in the joints. It acts anti. It provides efficient operation of the brain. It increases energy increasing vigor of a man. The demand for vitamin B6 increases during pregnancy and breast-feeding infants. The natural product is: yeast, eggs, wheat germ, meat (liver), wheat bran, nuts, peanuts peanuts, soybeans. There is a hypothesis that can be synthesized by intestinal bacteria.
Deficiency of vitamin B6 causes abnormal metabolism of proteins, decrease in lymphocytes in the blood, causes a feeling of lethargy and fatigue intensifies.
Dosage: 1.5-2.5 mg daily (increased demand during pregnancy and lactation).
Biotin (vitamin H, co-enzyme R) is in a group of B vitamins, due to the presence of sulphur compounds it is involved in the synthesis of ascorbic acid (vitamin C). Also synthesized in the intestines. It enhances the production of hormones and regulates cholesterol levels. It reduces muscle pain. It prevents hair loss and graying of hair. It soothes the skin inflammations. No toxic effects. Often combined with other B group vitamins and vitamin A. The natural sources of biotin are: whole grain bread, yeast, eggs (yolk), milk, brown rice and cheese.
Daily demand: 100-300 mg per day
Vitamin C (ascorbic acid) it is a vitamin soluble in body fluids, can be taken from foods (fruits and vegetables), or as drug derived synthetically. The largest of its resources can be found in broccoli, Brussels sprout, kale, black currant fruit and hawthorn, citrus fruits, tomatoes, Savoy cabbage, potatoes. In fact, intake of vitamin C of the food products does not limit the absorbed quantity. Vitamin C (ascorbic acid) is a potent antioxidant, it is an antitoxic, increasing the immune system due to the elimination of risk of bacterial contamination. Vitamin C prevents rupture of blood vessels, affects the blood cholesterol level. It substantially increases the absorption of iron. Inhibits the growth of cancer cells. Lowers stress levels.
Vitamin C deficiency causes abnormal development of connective tissue, cracking capillaries, abnormal calcification of bone tissue, impaired absorption of iron, scorbutus. With the lack of vitamin C, all kinds of injuries do not heal up properly. Vitamin C deficiency can be caused by smoking; each cigarette is destroying up to 100 mg of vitamin C.
Dosage: The demand is 60-80 mg daily. It does not limit the ability to consume higher doses. Some side effects may occur only with longer taking of synthetic vitamin C.