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Ornithine – a non-proteinogenic amino acid which plays an important role in the urea cycle. It neutralizes ammonia, which is a metabolic waste.
The toxic ammonia is a metabolic product of amino acid deamination – a reaction sequence by which proteins (amino acids) are broken down in order to obtain keto acids which make it possible to generate energy during cellular respiration.
Mechanism of ornithine action:
Ornithine is a product of the action of enzymes on L-arginine. Then, it combines with carbamoyl phosphate (a compound that consists of ammonia and carbo dioxide) forming citruline, which takes part in further metabolic changes that lead to the precipitation of urea.
Ornithine detoxicates the liver:
Ornithine (in a form of LOLA – L-Ornithine L-aspartate) is used to improve the process of ammonia reduction, as it accelerates the ammonia synthesis in the urea cycle that takes place in the liver. It improves the process of detoxication of liver and brain calls, it has a positive effect on protein, fat and carbohydrates metabolism and it can regenerate already damaged liver cells.
Ornithine improves the quality of sleep:
The psychoactive mechanism of ornithine action has not been explained yet, but the research show that ornithine improves the quality of sleep, reduces mental stress and increases the secretion of growth hormone.
By applying ornithine in the evening or just before sleep, you will improve the quality of your sleep, reduce stress and annoyance, relax and calm yourself down. (In the research, the dose was 500 mg of ornithine hydrochloride.)
The participants of the experiment fell asleep faster, they slept longer and they woke up feeling rested and refreshed. During the day, they also felt better.
Ornithine reduces cortisol concentration in blood:
Cortisol is probably the most hated hormone in the world of sculpting sports. It is hardly surprising, because although its proper level has a positive effect during body shaping, persistently high level of this hormone (for example caused by training and lack of rest) increases catabolic breakdown of muscle and promotes fat storage.
It is very interesting, however, the fact that ornithine can lower the cortisol level in blood requires further research. Some research has been already done on this subject – one group consisted of people who drank alcohol in the evening. In comparison to placebo recipients, the cortisol level in the morning, after waking up, was lower in the group of people who were using ornithine.
To sum it all up, Swanson L-Ornithine is a dietary supplement that has numerous prohealth and therapeutic properties. The product is recommended for people who overload their liver metabolism (with alcohol, unhealthy diet, medicines) and for those who suffer from sleeping problems and chronical stress.
Taking ornithine and arginine at the same time we may contribute to lowering the risk of diarrhea occurrence, which is a common side effect of using arginine on its own.
SWANSON is a well known company operating since 1969, which offers a wide selection of diet and nutritional supplements. Among their products are antioxidants, amino acid supplements, products improving immunity, probiotics, minerals and vitamins. At SWANSON you can also purchase of supplements enhancing your cardiovascular stamina, urinary, nervous and digestive systems. The offer includes products designed specifically for women or men, as well as supplements helping to loose weight.
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Ornithine belongs to endogenous non-protein amino acids, it is produced by transformation of the amino acid arginine and glutamic acid. It is an intermediate in a metabolic cycle urea synthesis from ammonia and carbon dioxide. The degradation of amino acids in the liver making the first removes nitrogen (alpha amino groups are transferred to alpha-ketoglutarate) and leads to the formation of glutamate, transformed into the form of ammonium ions. It is necessary to neutralize the highly toxic ammonia, which is carried out by aspartate, creating argininosuccinate. A further phase of change is the formation of arginine and fumarate. Then the cycle is repeated. In the transition process, ornithine is the starting material for the enzyme that catalyses a particular stage of the urea synthesis. It is also an acceptor for the synthesis of citrulline. Ornithine, through the synthesis of polyamines, has a regenerating effect on the liver.
Ornithine is available as mono-preparation (often included with the other ingredients of supporting liver function) and multi-component supplements containing ornithine aspartate. Indispensable in sports supplementation in no-boosters (pre-workout products) as it stores the arginine, it slows down its expenditure and allows for more effective use in the synthesis of nitric oxide. Available in the full range at: www.muscle-zone.pl
Dosage: There are no specific standards for daily consumption. 200 - 1500 mg / 24h, commonly used in supplementation.
Chlorine (chemical element from the group of halogens) - in the natural form of gas it is poisonous and water-soluble (until recently used as a disinfectant in the water supply system, now replaced by fluorination). It is chemically active element. It is used in the form of sodium chloride (NaCl) and potassium (KCl). It participates in the process of digestion and maintains acid-base balance in the body, removes toxic products of metabolism in the liver (antitoxin). Natural source of chlorine for the body is salt and bladderwrack.
Chlorine deficiency can occur due to excessive sweating, vomiting, causing digestive tract problems. It also causes loss of hair and teeth.
Excess chlorine, for example. Drink excessive amounts of chlorinated water, destroys bacterial flora and vitamin E.
Dosage: Daily dose should not exceed 15 grams.
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