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Agmatine is a biogenic amine that occurs naturally in the human body and is formed by the decarboxylation of L-arginine. Agmatine is best known for its ergogenic properties, which is why it is especially appreciated by athletes and strength trainers. However, not everyone knows that agmatine has unique properties for the nervous system - it has a procognitive and neuroprotective effect as well as an antidepressant potential.
Agmatine increases the concentration of nitric oxide (NO), responsible for vasodilation, i.e. the muscle pump. Agmatine increases NO levels in a different way than L-arginine, the precursor to NO. Agmatine activates endothelial nitric oxide synthase (eNOS) mainly through α2-adrenergic receptors, leading to increased production of NO. The phenomenon of the muscle pump enables optimal muscle nutrition, which translates into an increase in endurance during training.
The widely documented neuroprotective properties of agmatine result, among others, from from the inhibition of NMDA receptors. NMDA receptors belong to the glutamatergic system, and their blockade protects against the so-called glutamate excitotoxicity - excessive stimulation of NMDA receptors by glutamic acid, leading to damage to various structures of the nervous system, and in the long term contributing to the development of diseases of the nervous system.
Improving your mood
Agmatine has a positive effect on the mood and has antidepressant potential. Agmatine increases the secretion of the most active opioid peptide - β-endorphin, which has a positive effect on mental well-being and reduces the feeling of pain. This is very important, for example, during intensive training.
Sensitivity to stimulants
Agmatine has a unique feature of increasing the body's sensitivity to stimulants. It is especially important for people who regularly use stimulants, e.g. in the form of pre-training preparations. Frequent use may lead to an increase in tolerance to stimulants and, as a result, to the need to increase doses, which is not beneficial for health in the long run.
Due to the sensitizing effect on stimulants, it is worth adding agmatine to the pre-training preparation used. This will prevent the development of tolerance.
It is not recommended to take agmatine with a meal containing larger amounts of protein, as protein may reduce its absorption.
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|per portion (1 capsule)||amount||%DV|
|Agmatine sulfate||500 mg||-|
Microcrystalline cellulose, rice flour, gelatin (capsule shell).
Agmatine sulfate is a compound of agmatine, and hence the substance resulting from the processing of arginine.
It meets the body's range of functions, including increases levels of nitric oxide responsible for vasodilation and thus improves blood circulation. It stimulates the release of growth hormone and testosterone. It increases the amount of nutrients delivered to the muscles, and normalizes blood glucose levels, thereby mimicking the operation characteristic of insulin; improves the functioning of the central nervous system; fights free radicals; reduces depot body fat, and also affects the metabolism of calcium, thus providing a better functioning of the heart, brain and muscles.
Dosage: 500-1500 mg, the best half an hour before training.