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Phenibut (β-phenyl-γ-aminobutyric acid) is a phenyl derivative of GABA – the primary inhibitory neurotransmitter. The compound was first synthesized in Russia. Phenibut shows agonism to GABA-B receptors, which makes its mechanism of action similar to baclofen, registered as a drug in spastic conditions of various origins. Phenibut has several dozen times weaker activity than baclofen.
Penetration through the blood-brain barrier
Unlike exogenously ingested GABA, Phenibut can cross the blood-brain barrier, which is why it can increase GABA levels in the brain. This results in a stronger effect than supplements containing GABA.
The impact on the GABA-ergic system
Phenibut, stimulating GABA-B receptors, mimics the action of GABA. GABA has an inhibitory effect on the nervous system, which is manifested by the relief of anxiety and stress, sedation, calming down, and reduction of the excessive tension of skeletal muscles.
Positive effect on mood
Phenibut exerts a slight dopaminergic effect, which is often manifested by an improvement of well-being, an increase of the sense of pleasure, and a reduction of social stress. Hence, it is often used by shy people with social anxiety. Nevertheless, note that phenibut has some addictive potential.
Calm, relaxing sleep
Muscle relaxation and reduction of stress levels undoubtedly facilitate falling asleep. Calm and deep sleep is essential for optimal body regeneration, well-being, and high productivity.
However, regardless of the goal, it is advised to start the supplementation with the smallest portion to assess the effective dose – the effect intensity may vary depending on the body. Phenibut should only be used on an ad hoc basis. To avoid the development of tolerance or withdrawal syndrome, it should not be used too often (up to 2-3 times a week).
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Labolic offers a wide range of products specially tailored to satisfy customers’ needs and exceed expectations. Our store offers substances of the non-steroidal selective androgen receptor modulator (SARM) group. It is a class of androgen receptor (AR) ligands that bind AR and display tissue-selective activation of androgenic signalling, demonstrating anabolic potential in skeletal muscle. We also offer substances other than SARMs with similar properties and effects. Additionally, we have top-quality yohimbine and α-yohimbine preparations, which are commonly used to support fat burning.
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Phenibut (β-phenyl-γ-aminobutyric acid) - a chemical compound which is a derivative of two substances with important influence on psychological state of a human being: gamma-aminobutyric acid and phenylethylamine. It demonstrates a calming effect, facilitates relaxation and is recommended in the therapy of anxiety states. At the same time, it does not cause deterioration of sensorimotor abilities and does not increase the level of sleepiness, enabling normal functioning (however, it needs to be highlighted that there are no reliable sources regarding the influence of Phenibut on the ability to drive vehicles).
Some sources also say that Phenibut is able to increase the level of dopamine. Therefore, β-phenyl-γ-aminobutyric acid may increase the level of motivation and willingness to act.
The organism of a human being can quickly develop tolerance to Phenibut, therefore it is not suitable for constant supplementation. It is effective only as a temporary measure - its activity is much weaker as early as in the second day of application.
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