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Swanson AjiPure L-Methionine is a dietary supplement providing 500 mg of L-methionine amino acid in one portion. The preparation was created in cooperation with a Japanese company Ajinomoto, which produces amino acids with pharmaceutical quality. A patented method of production - AjiPure® based on fermentation of natural materials ensures almost 100% pureness of the substances.
L-methionine is an exogenous amino acid containing in its molecule a sulfur atom. Exogenous amino acids need to be provided to the organism from outside, as the organism does not have the enzymatic systems that would enable their synthesis. L-methionine constitutes a substrate for the synthesis of many active substances taking part in many important metabolic processes. Optimal efficiency of these processes is essential to maintain proper functioning of the organism.
L-methionine becomes converted in the organism to S-adenosyl L-methionine (SAMe), as a result of transporting adenosyl group ATP on the molecule of methionine. This process is catalyzed by the enzyme called methionine adenyltransferase. SAMe is a biologically active form of methionine, functioning as a universal donor of methyl groups in the organism. It takes part in many reactions of transmethylation, for which substrates are proteins, nucleic acids and phospholipids.
Methylation dependent on SAMe conditions the synthesis of phosphatidylcholine, a compound essential to maintain the structure and functions of cell membranes. It constitutes the source of choline, which is a precursor for the key transmitter in the nervous system – acetylcholine, which has massive influence on the processes of memorization and mood. Choline is also essential to create myelin sheaths, which ensure optimal pace of transmitting nerve impulses and protect neurons, which positively influence intellectual abilities and cognitive functions.
There are some reports on antidepressant properties of SAMe. It is related to increasing the amount of serotonin in the brain by SAMe (which constitutes the mechanism of activity of tricyclic antidepressants). One of the theories of developing depression are metabolism disorders of one of carbons related to transmethylation in the processes of neurotransmitter synthesis. Control research shows that SAMe is more effective in the treatment of depression than placebo and comparable to the effect of tricyclic antidepressants (TCAs).
L-methionine is used for the synthesis of glutathione. Glutathione is a tripeptide which constitutes an incredibly important antioxidant system of the organism. It appears most abundantly in the liver, where it enables the elimination of the harmful substances. It is coupled with xenobiotics (unfamiliar substances to the organism), i.a. with free radicals, inactivating them, making them harmless to the organism. Glutathione deficiency results in non-complete metabolism of these foreign substances, the example of which is the reaction with the active, hepatotoxic metabolite of paracetamol – N-acetyl-p-benzoquinone imine (NAPQI). Insufficient amount of glutathione causes that NAPQI is not completely bound, which leads to liver necrosis.
To sum up, Swanson AjiPure L-Methionine is a high-quality dietary supplement. It positively influences the comfort of life. It is especially recommended to people with depression, bad mood and mood fluctuations, in order to support liver, improve memory and intellectual abilities and also as prophylaxis.
Studies published for the „Journal of Psychiatry & Neuroscience” say that the preparations composed of methionine increase the level of SAMe to a larger extent that the supplements containing SAMe.
For better effects of supplementation, it is recommended to additionally apply a good-quality complex of B-group vitamins.
SWANSON is a well known company operating since 1969, which offers a wide selection of diet and nutritional supplements. Among their products are antioxidants, amino acid supplements, products improving immunity, probiotics, minerals and vitamins. At SWANSON you can also purchase of supplements enhancing your cardiovascular stamina, urinary, nervous and digestive systems. The offer includes products designed specifically for women or men, as well as supplements helping to loose weight.
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|per portion (1 capsule)||amount||%DV|
|AjiPure® PharmaceuticalGrade L-Methionine||500 mg||†|
Rice flour, cellulose (vegetable capsule), may contain one or both of the following: magnesium stearate, silica.
Exogenous methionine is an amino acid containing sulphur in its composition. It provides multi metabolism, with the indispensable help of vitamin B6. Participates in the synthesis of phospholipids (e.g. Lecithin), carnitine responsible for transport in the body of long-chain fatty acids, burned in the mitochondria cells (organelles in cells with a separate kernel), along with cystine forms cysteine. It is in the body antioxidant function. Natural source of acquisition of methionine are high-protein foods of animal origin (eggs, meat, fish), vegetable (sesame seeds, grain products). Available in all protein and carbohydrate protein and amino acid supplements such EAA and contain so-called all-day amino acids, supporting the liver preparations and cosmetics supporting the growth and condition of hair, skin and nails.
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