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Glucosamine & Chondroitin Extra Strength is a dietary supplement that helps to maintain the normal structure of the musculoskeletal system and improve the condition of joints. The preparation contains a unique, highly assimilable composition of glucosamine sulphate, and chondroitin sulphate of natural origin (bovine cartilage).
Glucosamine is a natural substance, a glucose derivative, synthesised in the organism from glucose and glutamine molecules in the presence of the enzyme glucosamine synthetase. Glucosamine is produced in the organism in little amounts, and the ability to synthesise it decreases with age. A relatively high content of glucosamine in joint cartilage was a signal for scientists that the substance can prove very beneficial when it comes to osteoarthritis.
Glucosamine is a substrate for the production of glycosaminoglycans and proteoglycans, which constitute a component of the intracellular substance in cartilage. As glucosamine cannot be found in any food product, it must be delivered in the form of supplements.
Benefits from using glucosamine
Chondrocytes (cartilage tissue cells) have been demonstrated to use glucosamine for integrating its molecules into glycosaminoglycan chains. Glucosamine also has the ability to reduce the activity of selected enzymes (for example matrix metalloproteinases), which participate in the degradation of joint cartilage.
The beneficial effects of glucosamine have also been observed in the case of cartilage tissue with osteoarthritis. As a result of improper regenerative processes, dividing chondrocytes have trouble reaching the damaged areas of the cartilage, the reason being for example that the capability of adhesion to intracellular matrix proteins is decreased. It has been demonstrated that glucosamine sulphate taken in the dosage of 50-500 µmol helps to improve the adhesive properties of proteins (especially fibronectin) in chondrocytes obtained from bones with degenerative lesions, thanks to which it supported the regenerative processes of damaged tissues.
Glucosamine is also believed to be able to help to inhibit the activity of pro-inflammatory cytokines IL-1β and reduce the synthesis of prostaglandins (PGE2) and nitrates, which can explain its beneficial effect on improving regenerative processes.
People who took glucosamine were demonstrated to have a milder course and pains than patients who struggled with regular discomfort caused by their joints. Other tests showed pain reduction, a less pressing need to take analgesics, and a general improvement of well-being in people with osteoarthritis of the knee. Moreover, it turned out that supplementation enhances joint mobility and general physical activity in patients.
Chondroitin is an organic compound of the glycosaminoglycan group. It is a mucopolysaccharide consisting of alternating glucuronic acid residues and N-acetylgalactosamine. Chondroitin is part of joint cartilage and helps to reduce friction between the mobile elements of the joint.
Activity of chondroitin
Chondroitin exhibits anti-inflammatory properties and stimulates the production of synovial fluid, thanks to which it supports joint mobility, increases cushioning, and reduces inflammations and pain.
Chondroitin is a compound produced in the organism, so it is constantly used during movement. The substance can be delivered with food, although it is found mainly in bovine and shark cartilage, which are products with strongly limited availability; therefore, both chondroitin and glucosamine are worth supplementing in the comfortable and efficient form of tablets.
To sum up, Now Foods Glucosamine & Chondroitin is a dietary supplement recommended especially for physically active people. The preparation is an indispensable element of everyday supplementation among people exposed to an increased risk of fractures, falls, and other injuries that lead to pain and discomfort during exercising.
Excessive joint exploitation does not only concern sportspeople, so the preparation is also recommended for overweight people, the elderly, and those who do heavy physical work. The supplement can also prove fantastic in the case of joint pains and their limited mobility that accompany osteoarthritis.
The commonly used, efficient doses of glucosamine and chondroitin are respectively 1,500 and 1,200 mg. What’s very important, the doses are contained in the portions recommended by the manufacturer (2 capsules). In order to obtain as many benefits from using the preparation as possible, take it regularly for 6-12 weeks, especially if you are in the risk group (sportspeople, seniors, blue-collar workers) and when first symptoms occur signalling the deterioration of the musculoskeletal system.
Now Foods is a company with years of experience in the industry that offers a wide range of nutrients and dietary supplements. Brand is known for its high-quality products designed for hair and nails and supplements supporting the immune system. The offer includes the antioxidant supplements, antibacterial supplements, reducing appetite supplements, products supporting the reduction of body fat and improving digestion. All products are made from natural ingredients.
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Cellulose, Stearic Acid (vegetable source), Magnesium Stearate (vegetable source), Silica and Vegetable Coating.
Calories are the conventional name of the unit expressing the energy value of food, the demand and energy expenditure in human body, which in fact is 1 kilocalorie (1 kcal). 1 kilocalorie is the amount of thermal energy required to heat 1 g of water and 1 degree Celsius. The SI unit of thermal energy is 1 joule (1J), equal to approximately 4,185 kcal.
The energy value is determined by the chemical composition of the food product, by means of the so-called. physiological equivalents. Most often Atwater equivalent is used: ratio for protein 4 kcal / g, for carbohydrates 4kcal / g, and for fat - 9kcal / g.
The energy value carried out with the so-called. "Caloric bomb" is equivalent to the physical energy, amounting to 4.1 kcal per 1 g carbohydrate to 5.65 kcal per 1 g protein, 9.45 kcal per 1 g of fat.
Nutritional value, determines the suitability of a food product for realizing life functions of human, the higher it is - the higher bioavailability and lower quantity for consumption for obtaining the effects.
Carbohydrates are an essential nutrient. They are divided into: simple sugars (monosaccharides), disaccharides and polysaccharides. In terms of the human bioavailability of carbohydrates is divided into: digestabe, those which are digested in the gastrointestinal tract by transferring energy to the tissues or cells (such as starch, fructose) and indigestable, resistant to digestive enzymes (e.g. cellulose) . Affects blood glucose levels (glycemic index) and the metabolism of insulin (insulin index). The greatest demand for carbohydrates occurs before physical activity or in the middle of it, because they increase the exercise capacity, consumed after exercise provide regeneration. In the sports diet the absorption rate it is important of carbohydrates and reactions of the organism. Available in mono-preparation supplements and part of the energetic supplements, creatine stacks, nitrogen boosters.
Dosage: according to the statistics of the Institute of Food and Nutrition, carbohydrates should comprise about 50% of daily energy intake. In some diets, used residual carbohydrate consumption, not exceeding 30g / 24h.
Sodium is an important component of the intracellular fluids, and is a regulator of acid-base balance. Along with potassium affects the proper of growth and provides the proper functioning of muscles and nerves. The source of acquisition is table salt (NaCl) and bladderwrack, shellfish, bacon, beef, and of plant beets and carrots. People on salt-free diet should avoid, among others, spicy sauces and smoked meats and sausages.
Sodium deficiency is very rare, at heaving sweating after a long effort (e.g. in the marathon).
Excess sodium increases blood pressure (especially for the elderly), edema and increased thirst. Exceeding the daily dose of 14g a day can cause poisoning.
Glucosamine sulphate (glucosamine) is an amino sugar present in cartilage matrix; compound needed for the glycosaminoglycans and proteoglycans, affecting its structure and flexibility, increasing immunity to overloads. Glucosamine is synthesized in the human body, it can be supplied from the outside (a component of shells of marine crustaceans, and in coatings for fungi) as supplements. Increased demand for glucosamine occurs in sports training (athletes exposed to overload the musculoskeletal system), during convalescence after injuries and contusions, moreover, in the case of older people in prevention and therapeutic of degenerative changes of the locomotor system. Glucosamine occurs as mono-preparation or multiple preparations (including, among others, hyaluronic acid and chondroitin, collagen hydrolyzate and ascorbic acid) in supplementation in supporting the functioning of the musculoskeletal system, such as d-glucosamine sulphate 2KCl; HCL Poly NAG.
Dosage: 500-1500 mg per day.
Potassium and sodium regulate the body's water resources, ensuring normal heart rhythm. Maintaining the proper level of potassium provides the proper oxidation of the brain, lowers blood pressure, increases the permeability of cell membranes (as an antagonist of calcium). It is a base-forming element. It is widely used in sports diet before and after training in the form of supplements, nutrients, vitamin-mineral preparations and minerals, concentrates and ready, isotonic and hypertonic beverages. Natural sources of acquisition of potassium are: vegetable products (bananas, citrus fruits, melons, mint leaves, green vegetables, potatoes) and animal products (sea fish, meat). Potassium is present in the form of organic compounds: citric acids, and fumarates gluconates and inorganic (chlorides, sulfates, oxides and carbonates).
Potassium deficiency (hypokalemia): excessive tiredness, headaches and irritability, problems with sleeping, muscle cramps, constipation. Potassium levels may drop sharply in the event of a reduction in blood sugar levels, prolonged starvation, severe diarrhea. They can occur when too much of strong coffee is consumed, with alcohol abuse and when eating too much sweets.
The excess of potassium (hyperkalemia) is often the cause of depression, hypotension, tingling in the extremities.
Chondroitin sulfate has chondroitin in its composition, belonging to the glycosaminoglycans, affecting the maintenance of joint stability and strength (building component of cartilage). Chondroitin sulfate proteins involved with the synthesis of proteoglycans. It is synthesized in the body or delivered in the foods of animal origin (e.g. containing tissue). It is used by athletes in the disciplines greatly aggravating the locomotor system with exercises, as well as in the treatment of sports injuries and joint recovery and rehabilitation after injuries, increased demand also occurs in people of advanced age. In the sports supplementation is a component of multi-component combined supplements, often containing hyaluronic acid, glucosamine and hydrolysed collagen, supporting the functioning of the locomotor system.
Dosage: 500-1500 mg per day.
Salt (sodium chloride, or table salt), natural source of electrolytes (chlorine and potassium), regulating water and electrolyte and acid-base balance of the body, affecting the nervous system and blood pressure. Sodium is an essential element for the proper growth. The proper dose of salt prevents overheating of the body and solar stroke. It provides the proper functioning of muscles and nerves the body. Chlorine in combination with sodium, is involved in the digestive process and maintains acid-base balance in the body, as antitoxin removes toxic products of metabolism in the liver. Salt is a flavour component and preservative of many foods, nutritional supplements and mixtures of electrolytes, available at www.muscle-zone.pl
Dosage: no specific standards of consumption, used so as to provide sufficient amount of electrolytes to the body (sodium and chloride).
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