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Humaslin Humaslin

Condemned HumaSLIN is a unique product which increases the use of glucose by muscle cells. By providing active compounds activating the insulin pathways and enzymes increasing saccharides breakdown in the digestive tract, it intensifies the use of carbohydrates provided with a meal as an important source of energy and the use of energy substrates stored in form of glycogen. It provides glucose to myocytes instead of adipocytes, which accelerates muscle regeneration and reduces formation of adipose tissue.

CONDEMNED HumaSLIN contains:
Cinnamon bark ‒ the powdered inner bark obtained from the tree species from the genus Cinnamomum, a subtropical plant belonging to the family Lauraceae growing on the moist soils in South East Asia. Because of its unusual taste and beneficial properties, for centuries it has been valued as a unique spice and an agent supporting the health of the human body, appreciated mainly by the traditional Chinese medicine. Cinnamon contains many important chemical compounds, including cinnamon aldehydes, responsible for its aroma, and health-promoting methyl hydroxy chalcone polymers (MHCP). Its antioxidant activity reduces oxidative stress and declines the level of adverse changes caused by the products of lipid peroxidation. Reducing the activity of NF-κB, iNOS and COX-2 suppresses inflammations. Cinnamon delays the intestinal glucose absorption after meal, as it inhibits the activity of some enzymes, mainly pancreatic α-amylase and α-glycosidase. It stimulates cellular glucose uptake, as it promotes translocation of glucose transporter 4 (GLUT4), accelerates glucose metabolism and increases glycogen synthesis, which slows down glucose synthesis in the body system during gluconeogenesis and affects important regulating enzymes. It increases insulin secretion and enhances its action as well as directly stimulates the activity of insulin receptor, which results in insulin-mimetic properties. Cinnamon supports insulin-carbohydrate management and thus promotes the maintenance of the proper blood sugar level and body weight. It affects regulation of insulin-carbohydrate management, which reduces the levels of triglycerides, cholesterol and LDL, while it raises HDL level and thus promotes the proper lipid profile, beneficial for the health of the cardiovascular system. Cinnamon helps to reduce high blood pressure, however this mechanisms are not fully investigated yet. Moreover, it relaxes the vascular muscles, probably by affecting the functions of channels involved in the transport of calcium ions. It maintains the proper functioning of the circulatory system. Furthermore, it regulates the mRNA level and expression of collagen protein, as it i.a. increases phosphorylation of IGF-1 receptor and supports collagen structures in the body system. It inhibits tau aggregation and fibre formation as well as promotes the breakdown of tau fibres, which supports the proper condition of the nervous system and promotes neuronal signalisation. Cinnamon shows wide antibacterial properties, also against Helicobacter pylori, it has antifungal and antiparasitic potential, reduces the level of harmful microbes and other heterotrophs as well as supports the digestive system.

Gymnema extract ‒ obtained from plants of Gymnema species. The name refers to Gymnema sylvestris, (or Meshashringi and Gurmar), a species belonging to the Apocynaceae family, a slowly growing plant characteristic for the tropical areas of India, Africa, and Australia. Due to its health-promoting properties, it has been used in the traditional Hindi medicine. The active substances contained in the plant include triterpenoid gymnemosides, belonging to glycosides known also as gymnemic acids. It slows down glucose absorption, by blocking particular receptors in the intestines as well as raises the effectiveness of insulin action, thanks to modulation of incretin activity and promoted regeneration of pancreatic islets cells responsible for secretion of particular hormones. Moreover, it increases glucose secretion by raising the activity of enzymes involved in glucose metabolism i.a. glyceraldehyde 3-phosphate dehydrogenase GAPDH), stimulating phosphorylase activity and reducing the activity of gluconeogenic enzymes and sorbitol dehydrogenase. Gymnema shows hypoglycaemic properties promoting the proper blood sugar level and insulin-carbohydrate management. It reduces receptor activity in the taste buds responsible for sweet taste reception in the presence of sugar molecules provided with food, and thus it reduces satisfaction resulting from sugar consumption, which facilitates the control over body weight. By decreasing the rate of cartilage degradation and by reducing joint swelling and pain by inhibiting inflammatory cell responses or by blocking the release of inflammatory mediators, including IL-Ib and TNF-a cytokines, GM-CSF, interferon and PGDF, it helps to maintain optimal condition of the articular system. Improving the concentration of cholesterol, triglycerides, LDL and HDL promotes the proper lipid profile. Its immunostimulating properties resulting from the influence on the neutrophil activity promote the proper functioning of the immune system. Reducing the development of many bacteria species (including S. aureus, E. Coli, or B. Subtilis), however without affecting the Gram-negative bacteria, results in wide bactericide properties. Fighting the plaque Gram-positive bacteria (i.a. S. aureus, S. mitis and S. Mutans) and Candida albicans fungi (responsible for demineralisation of tooth enamel) reduces the risk of tooth decay.

Fenugreek extract ‒ standardised for the high content of saponins, obtained from Trigonella foenum-graecum seeds. It is an annual small plant from the Fabaceae family, originated from Asia and East Europe, however present all over the world. The numerous active substances contained in the plant include saponins, which are substances classified as glycosides, containing sapogenins and saccharides. Raising the level of triiodothyronine (T3) and thyroxine (T4) promotes combustion of energy substrates, reduces their initial level and further accumulation. Reducing degradation of pancreatic cells and promoting insulin secretion supports the proper functioning of the pancreas. Raising PI3K activity increases uptake of carbohydrates from blood by myocytes, which increases muscle cell tolerance to glucose and reduces insulin resistance of the body system. Increased glucose inflow into muscle cells promotes formation and accumulation of energy substrates in form of glycogen. Normalised carbohydrate management counteracts spikes of blood sugar. The substance affects appetite, which reduces consumption of fats. Reduced absorption of cholesterol from digestive tract promotes the proper lipid profile. Higher activity of androgen receptors supports formation of muscle structures. Reduced activity of 5-α-reductase slows down testosterone transformation to dihydrotestosterone (DHT), which reduces androgen receptors stimulation within the prostate and slows down prostatic hyperplasia. The substance enhances sex drive. As it affects the serotonergic system activity, it can reduce pain. Higher effectiveness of antioxidant barrier, resulting from increased stimulation of antioxidant enzymes, reduces oxidative damage within liver structures and promotes better functioning of this organ.

Alpha lipoic acid (ALA) ‒ or 6,8-dithiooctanoic acid, is a sulphuric compound classified as a saturated fatty acid. Due to the presence of one stereocenter, it is classified as a chiral substance of two forms, R and S, while the isoform R is active. It is present in large quantities in yeasts, liver, kidneys, beef hearts, spinach, broccoli and potatoes. The main effects of this fatty acid result mainly from its antioxidant properties. It is a direct reducer of reactive oxygen species and it restores other antioxidant substances, i.a. coenzyme Q10, vitamins C and reduced glutathione (GSH). It stimulates the Nrf2 path, which raises the level of cysteine that can be used by appropriate enzymes catalysing the production of GSH. It chelates numerous metals, including: Zn2+, Cu2+ and Pb2+, and its reduced form (DHLA) binds also Fe3+ and Hg2+, which slows down the production of free radicals. Moreover, ALA increases the capacity of antioxidant barrier. It is soluble in both fat and water, so that it can show its antioxidant activity all over the body system, in- and outside of cells. Due to its multidirectional antioxidant mechanism, the compound is considered to be the best antioxidant. It reduces oxidative stress and inflammations. It is an important cofactor of mitochondrial catalytic subunits, i.a. a complex splitting glycine and numerous α-keto acid dehydrogenases. ALA is responsible for the proper energy management. It reduces insulin breakdown and beta pancreatic cells degradation, which stimulates the activity of kinase activated by AMP (AMP-activated protein kinase). This facilitates glucose transporter 4 (GLUT4) transport to the surface of cell membranes as well as promotes glucose combustion and supports insulin-carbohydrate management. It minimises insulin resistance and supports glucose tolerance, which promotes the optimal blood sugar level. The proper insulin-carbohydrate management facilitates the control over body weight. Its antioxidant properties protect the structures of vascular endothelium from oxidative damage. ALA reduces vascular inflammations and blood pressure, as it promotes eNOS phosphorylation responsible for nitric oxide synthesis, which relaxes vascular smooth muscles and keeps the cardiovascular system in good condition. Raising the effectiveness of antioxidant barrier prolongs the lifetime of neurons. It easily crosses the blood-brain barrier, so that it protects brain structures from oxidative stress and excessive amounts of iron ions. This supports the high brain efficiency. It increases the level of GSH in the liver, which improves protection against free radicals, heavy metals (Pb, Hg and Cd), alcohol and some toxins. This results in hepatoprotective properties.

Corosolic acid derived from Banaba ‒ a pentacyclic triterpen structurally similar to ursolic acid, most often extracted from the leaves of Lagerstroemia speciosa, a plant popularly known as Banaba, a tropical and subtropical tree originating from South Asia. It inhibits hydrolysis of carbohydrates, as it reduces glycosidase activity, especially α-amylase, slows down absorption of monosaccharides into bloodstream, which reduces sudden spikes in blood sugar levels. By increasing phosphorylation of insulin receptor and the activity of glucose transporter 4 (GLUT4) in myocytes, it reduces insulin resistance, which increases the efficiency of glucose uptake by cells and the effectiveness of sugar use as well as reduces their excessive accumulation. It accelerates the metabolism of carbohydrates, as it supports glycolysis and increases the activity of glucokinase, without affecting the activity of glucose-6-phosphatase. Corosolic acid increases expression of receptors activated by proliferator of peroxisomes PPAR-α in the liver and PPAR-γ in the white adipose tissue, which improves fat metabolism. It inhibits cholesterol acyltransferase, reduces cholesterol level and thus improves lipid profile. It shows anti-inflammatory properties and supports the maintenance of oxidative balance. Stimulating osteoblast differentiation, resulting from activation of the mitogen-activated protein kinase (MAPK), NF-κB and activating protein-1 promotes the health of skeletal system.

Vanadium ‒ a chemical element, classified as a transient metal. In nature, it occurs mainly in dispersible form. Its role in the human body system is not fully researched yet, however it is considered to be a micronutrient. It has been demonstrated that the element is highly involved in the activity of numerous metabolic paths, activating particular enzymes, such as phosphatase and ATPase. It blocks the activity of protein tyrosine phosphatase 1B (PTP-1B), enhances the activity of insulin-like growth factor I receptor (IGF-IR) that increases the level of GLUT-4 transporters which results in better glycogen regeneration and supports the efficiency of glucose synthesis in gluconeogenesis reactions. It inhibits protein kinase A activity, slows down release of glucose from glycogen and thus optimises blood sugar level. It increases the activity of enzymes promoting fatty acid formation and thus it affects energy management and supports the proper blood sugar level. Vanadium supports regeneration of pancreatic beta cells, promotes efficient functioning of the pancreas and thus the proper insulin-carbohydrate management. Its role is similar to the insulin role, as it is involved in insulin-carbohydrate management on different levels as well as supports proliferation and differentiation of cells as well as facilitates the quick growth and restoration of numerous structures in the body system. Reducing cholesterol level promotes the optimal lipid profile. It affects the concentration of 2,3- phosphoglyceric acid formed in erythrocytes and the affinity of hemoglobine to oxygen, which positively influences the efficiency of the circulatory system. The non-organic form of vanadium, vanadium sulphate, is widely a recognised chemical form of this micronutrient.

Chromium ‒ a transient metal. It is an important, but poorly absorbable mineral, which is provided in form of both organic and non-organic compounds, present in large quantities in cocoa, chocolates, wholegrain products, fishes, red meat and green vegetables, e.g. broccoli. It is present in active centres of enzymes, which is why it plays a core role in numerous metabolic processes. It increases the number of insulin receptors, improves insulin bounding with cells as well as stimulates particular kinases and reduces insulin resistance of cells. Chromium promotes glucose use by the body system, which maintains optimal blood sugar level. It is involved in insulin-carbohydrate management, which supports weight control. It promotes glucose absorption and ensures effective glycogen accumulation. It stabilises RNA, which prevents interferences in genetic material. It is involved in metabolism of carbohydrates and fats as well as optimises lipidogram. It is present in form of chromium picolinate, an organic form with chromium on oxidation stage 3+, which ensures efficient use of this micronutrient.

The complex of enzymes supporting digestion:
Invertase ‒ also known as β-fructofuranosidase or β-D-fructofuranoside fructohydrolase, commonly referred to as saccharase; an enzyme from the group of hydrolases. It is a glycoprotein catalysing the cleavage of β-D-fructofuranosidase residue from the non-reducing end of β-D-fructofuranosides. It allows for the breakdown of saccharose, raffinose, kestose, nystose, oligofructose and inulin. Among the invertase activators, the most common are magnesium, calcium and cobalt ions. Invertase is considered to be the earliest known enzyme. In 1860, M. Bertholet isolated the molecule from the yeast Saccharomyces cerevisiae. On large scale, it is obtained from yeasts by using mold and bacteria. In the industry, it is used in the production of invert sugar and artificial honey. The enzyme is valued in the prebiotic synthesis of oligosaccharides, including FIS and lactosaccharose, which allows for the development of probiotic bacteria.

Amylases ‒ is an umbrella term for several groups of enzymes: α-amylase (an endoamylase) and exoamylases. α-amylase, initially called diastase, is an enzyme randomly cleaving the α bound (1 → 4) in starch and glycogen. Products of its activity include maltose, maltotriose, glucose and α-dextrins. The enzyme does not hydrolyse the α bounds (1→6), which are characteristic for amylopectins. Amylase activators are calcium, chloride, strontium, barium, manganese and cadmium ions. In turn, its inhibitors are: iodine ions, chelators of bivalent ions, oxalate and citrate. The studies on this protein were started by Kirchhoft in 1811 and continued by Dubrunfant in 1830. It has been discovered that it can break down starch by using wheat extracts and barley malt.

Pectinases ‒ an umbrella term for enzymes breaking down complex pectin structure. They are divided by their mechanism of action into three groups: esterases, hydrolases and lyases. Pectinesterase induces deesterification of pectin methoxyl group and allows for the release of pectic acid. Polygalacturonase and polymethylgalacturonase, classified as hydrolases, cleave the α-1,4-glycosidic bounds in pectic acid and pectin. Polygalacturonate and polymethylgalacturonate lyases catalyse the breakdown of the α-1.4-glycosidic bound in pectic acid and pectin, thanks to trans-elimination and formation of unsaturated galacturonates and methyl galacturonates. About a half of pectinases comes from yeasts, the smaller part from bacteria, while only about 10% ‒ from plants and animals. They break down pectins to reducing sugars and release numerous compounds from their structures, e.g. polyphenols. Because of their properties, they are widely used in food industry, i.a. for reducing viscosity of fruit and vegetable products or improving clarification of juices and oils.

Alpha-galactosidase – or α-D-galactoside galactohydrolase. It is an enzyme classified as a glycoside hydrolase catalysing the breakdown of the α-D-glycoside bound in selected saccharides, glycoproteins and glycolipids. On industry scale, it is microbiologically obtained with participation of particular species of mold and bacteria strains. The enzyme improves the breakdown of raffinose and stachyose in the digestive tract. Such effects are particularly helpful in the diet rich in legumes containing stachyose, as they reduce bloating.

Glucoamylase ‒ also known as: α-1,4-glucan glucohydrolase and amyloglucosidase. It is an enzyme classified as amylase (exoamylase). It breaks down the 1,4- and the 1,6-glycoside bounds. It allows for the total breakdown of amylopectin and glycogen to glucose. Traditionally, the enzyme is obtained with participation of the thread-like fungi. In food industry, it is one of the oldest commonly used enzymes. It is used in processing starch and dextrin, for saccharification of this compound to glucose, which is then used for fermentation of food products.

To sum it all up, Condemned HumaSLIN is a unique product raising the effectiveness of glucose use by muscle cells. It provides different forms of carbohydrates, improves digestion and absorption of carbohydrates in digestive tract. It promotes insulin secretion, increases translocation of glucose transporter 4 (GLUT4), stimulates the receptor of insulin-like growth factor I (IGF-IR) and improves the activity of insulin receptor. By reducing the insulin resistance of myocytes, it provides glucose into muscle cells instead of fat cells. It improves insulin tolerance of myocytes, reduces fat uptake from digestive tract and stimulates the activity of triiodothyronine (T3) and thyroxine (T4) releasing energy substrates. It increases expression of receptors activated by proliferator of peroxisomes PPAR-α in the liver and PPAR-γ in the white adipose tissue, which intensifies metabolism of fats and improves lipid profile. The product affects insulin-carbohydrate and fat management and provides energy for intensive activities and muscle regeneration, which minimises energy substrates accumulation in form of stored fat. Moreover, it shows antioxidant, anti-inflammatory and detoxifying properties as well as supports many systems (cardiovascular, nervous, digestive and skeletal systems). It takes care of prostate, pancreas and liver.

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Humaslin Humaslin 60 caps.
CONDEMNED
£ 30.41

Humaslin 60 caps.

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Description
  • A product raising the use of glucose by muscles
  • Increases insulin secretion and improves its action
  • Raises the efficiency of glucose transport to myocytes
  • Promotes glycogen restoration in the muscles
  • Improves biological regeneration of muscles
  • Reduces fat accumulation
  • Improves lipid profile
  • Antioxidant properties
  • Reduces inflammations
  • Improves body system detoxification
  • Supports the condition of many systems
  • Takes care of prostate, pancreas and liver

Condemned HumaSLIN is a unique product which increases the use of glucose by muscle cells. By providing active compounds activating the insulin pathways and enzymes increasing saccharides breakdown in the digestive tract, it intensifies the use of carbohydrates provided with a meal as an important source of energy and the use of energy substrates stored in form of glycogen. It provides glucose to myocytes instead of adipocytes, which accelerates muscle regeneration and reduces formation of adipose tissue.

CONDEMNED HumaSLIN contains:
Cinnamon bark ‒ the powdered inner bark obtained from the tree species from the genus Cinnamomum, a subtropical plant belonging to the family Lauraceae growing on the moist soils in South East Asia. Because of its unusual taste and beneficial properties, for centuries it has been valued as a unique spice and an agent supporting the health of the human body, appreciated mainly by the traditional Chinese medicine. Cinnamon contains many important chemical compounds, including cinnamon aldehydes, responsible for its aroma, and health-promoting methyl hydroxy chalcone polymers (MHCP). Its antioxidant activity reduces oxidative stress and declines the level of adverse changes caused by the products of lipid peroxidation. Reducing the activity of NF-κB, iNOS and COX-2 suppresses inflammations. Cinnamon delays the intestinal glucose absorption after meal, as it inhibits the activity of some enzymes, mainly pancreatic α-amylase and α-glycosidase. It stimulates cellular glucose uptake, as it promotes translocation of glucose transporter 4 (GLUT4), accelerates glucose metabolism and increases glycogen synthesis, which slows down glucose synthesis in the body system during gluconeogenesis and affects important regulating enzymes. It increases insulin secretion and enhances its action as well as directly stimulates the activity of insulin receptor, which results in insulin-mimetic properties. Cinnamon supports insulin-carbohydrate management and thus promotes the maintenance of the proper blood sugar level and body weight. It affects regulation of insulin-carbohydrate management, which reduces the levels of triglycerides, cholesterol and LDL, while it raises HDL level and thus promotes the proper lipid profile, beneficial for the health of the cardiovascular system. Cinnamon helps to reduce high blood pressure, however this mechanisms are not fully investigated yet. Moreover, it relaxes the vascular muscles, probably by affecting the functions of channels involved in the transport of calcium ions. It maintains the proper functioning of the circulatory system. Furthermore, it regulates the mRNA level and expression of collagen protein, as it i.a. increases phosphorylation of IGF-1 receptor and supports collagen structures in the body system. It inhibits tau aggregation and fibre formation as well as promotes the breakdown of tau fibres, which supports the proper condition of the nervous system and promotes neuronal signalisation. Cinnamon shows wide antibacterial properties, also against Helicobacter pylori, it has antifungal and antiparasitic potential, reduces the level of harmful microbes and other heterotrophs as well as supports the digestive system.

Gymnema extract ‒ obtained from plants of Gymnema species. The name refers to Gymnema sylvestris, (or Meshashringi and Gurmar), a species belonging to the Apocynaceae family, a slowly growing plant characteristic for the tropical areas of India, Africa, and Australia. Due to its health-promoting properties, it has been used in the traditional Hindi medicine. The active substances contained in the plant include triterpenoid gymnemosides, belonging to glycosides known also as gymnemic acids. It slows down glucose absorption, by blocking particular receptors in the intestines as well as raises the effectiveness of insulin action, thanks to modulation of incretin activity and promoted regeneration of pancreatic islets cells responsible for secretion of particular hormones. Moreover, it increases glucose secretion by raising the activity of enzymes involved in glucose metabolism i.a. glyceraldehyde 3-phosphate dehydrogenase GAPDH), stimulating phosphorylase activity and reducing the activity of gluconeogenic enzymes and sorbitol dehydrogenase. Gymnema shows hypoglycaemic properties promoting the proper blood sugar level and insulin-carbohydrate management. It reduces receptor activity in the taste buds responsible for sweet taste reception in the presence of sugar molecules provided with food, and thus it reduces satisfaction resulting from sugar consumption, which facilitates the control over body weight. By decreasing the rate of cartilage degradation and by reducing joint swelling and pain by inhibiting inflammatory cell responses or by blocking the release of inflammatory mediators, including IL-Ib and TNF-a cytokines, GM-CSF, interferon and PGDF, it helps to maintain optimal condition of the articular system. Improving the concentration of cholesterol, triglycerides, LDL and HDL promotes the proper lipid profile. Its immunostimulating properties resulting from the influence on the neutrophil activity promote the proper functioning of the immune system. Reducing the development of many bacteria species (including S. aureus, E. Coli, or B. Subtilis), however without affecting the Gram-negative bacteria, results in wide bactericide properties. Fighting the plaque Gram-positive bacteria (i.a. S. aureus, S. mitis and S. Mutans) and Candida albicans fungi (responsible for demineralisation of tooth enamel) reduces the risk of tooth decay.

Fenugreek extract ‒ standardised for the high content of saponins, obtained from Trigonella foenum-graecum seeds. It is an annual small plant from the Fabaceae family, originated from Asia and East Europe, however present all over the world. The numerous active substances contained in the plant include saponins, which are substances classified as glycosides, containing sapogenins and saccharides. Raising the level of triiodothyronine (T3) and thyroxine (T4) promotes combustion of energy substrates, reduces their initial level and further accumulation. Reducing degradation of pancreatic cells and promoting insulin secretion supports the proper functioning of the pancreas. Raising PI3K activity increases uptake of carbohydrates from blood by myocytes, which increases muscle cell tolerance to glucose and reduces insulin resistance of the body system. Increased glucose inflow into muscle cells promotes formation and accumulation of energy substrates in form of glycogen. Normalised carbohydrate management counteracts spikes of blood sugar. The substance affects appetite, which reduces consumption of fats. Reduced absorption of cholesterol from digestive tract promotes the proper lipid profile. Higher activity of androgen receptors supports formation of muscle structures. Reduced activity of 5-α-reductase slows down testosterone transformation to dihydrotestosterone (DHT), which reduces androgen receptors stimulation within the prostate and slows down prostatic hyperplasia. The substance enhances sex drive. As it affects the serotonergic system activity, it can reduce pain. Higher effectiveness of antioxidant barrier, resulting from increased stimulation of antioxidant enzymes, reduces oxidative damage within liver structures and promotes better functioning of this organ.

Alpha lipoic acid (ALA) ‒ or 6,8-dithiooctanoic acid, is a sulphuric compound classified as a saturated fatty acid. Due to the presence of one stereocenter, it is classified as a chiral substance of two forms, R and S, while the isoform R is active. It is present in large quantities in yeasts, liver, kidneys, beef hearts, spinach, broccoli and potatoes. The main effects of this fatty acid result mainly from its antioxidant properties. It is a direct reducer of reactive oxygen species and it restores other antioxidant substances, i.a. coenzyme Q10, vitamins C and reduced glutathione (GSH). It stimulates the Nrf2 path, which raises the level of cysteine that can be used by appropriate enzymes catalysing the production of GSH. It chelates numerous metals, including: Zn2+, Cu2+ and Pb2+, and its reduced form (DHLA) binds also Fe3+ and Hg2+, which slows down the production of free radicals. Moreover, ALA increases the capacity of antioxidant barrier. It is soluble in both fat and water, so that it can show its antioxidant activity all over the body system, in- and outside of cells. Due to its multidirectional antioxidant mechanism, the compound is considered to be the best antioxidant. It reduces oxidative stress and inflammations. It is an important cofactor of mitochondrial catalytic subunits, i.a. a complex splitting glycine and numerous α-keto acid dehydrogenases. ALA is responsible for the proper energy management. It reduces insulin breakdown and beta pancreatic cells degradation, which stimulates the activity of kinase activated by AMP (AMP-activated protein kinase). This facilitates glucose transporter 4 (GLUT4) transport to the surface of cell membranes as well as promotes glucose combustion and supports insulin-carbohydrate management. It minimises insulin resistance and supports glucose tolerance, which promotes the optimal blood sugar level. The proper insulin-carbohydrate management facilitates the control over body weight. Its antioxidant properties protect the structures of vascular endothelium from oxidative damage. ALA reduces vascular inflammations and blood pressure, as it promotes eNOS phosphorylation responsible for nitric oxide synthesis, which relaxes vascular smooth muscles and keeps the cardiovascular system in good condition. Raising the effectiveness of antioxidant barrier prolongs the lifetime of neurons. It easily crosses the blood-brain barrier, so that it protects brain structures from oxidative stress and excessive amounts of iron ions. This supports the high brain efficiency. It increases the level of GSH in the liver, which improves protection against free radicals, heavy metals (Pb, Hg and Cd), alcohol and some toxins. This results in hepatoprotective properties.

Corosolic acid derived from Banaba ‒ a pentacyclic triterpen structurally similar to ursolic acid, most often extracted from the leaves of Lagerstroemia speciosa, a plant popularly known as Banaba, a tropical and subtropical tree originating from South Asia. It inhibits hydrolysis of carbohydrates, as it reduces glycosidase activity, especially α-amylase, slows down absorption of monosaccharides into bloodstream, which reduces sudden spikes in blood sugar levels. By increasing phosphorylation of insulin receptor and the activity of glucose transporter 4 (GLUT4) in myocytes, it reduces insulin resistance, which increases the efficiency of glucose uptake by cells and the effectiveness of sugar use as well as reduces their excessive accumulation. It accelerates the metabolism of carbohydrates, as it supports glycolysis and increases the activity of glucokinase, without affecting the activity of glucose-6-phosphatase. Corosolic acid increases expression of receptors activated by proliferator of peroxisomes PPAR-α in the liver and PPAR-γ in the white adipose tissue, which improves fat metabolism. It inhibits cholesterol acyltransferase, reduces cholesterol level and thus improves lipid profile. It shows anti-inflammatory properties and supports the maintenance of oxidative balance. Stimulating osteoblast differentiation, resulting from activation of the mitogen-activated protein kinase (MAPK), NF-κB and activating protein-1 promotes the health of skeletal system.

Vanadium ‒ a chemical element, classified as a transient metal. In nature, it occurs mainly in dispersible form. Its role in the human body system is not fully researched yet, however it is considered to be a micronutrient. It has been demonstrated that the element is highly involved in the activity of numerous metabolic paths, activating particular enzymes, such as phosphatase and ATPase. It blocks the activity of protein tyrosine phosphatase 1B (PTP-1B), enhances the activity of insulin-like growth factor I receptor (IGF-IR) that increases the level of GLUT-4 transporters which results in better glycogen regeneration and supports the efficiency of glucose synthesis in gluconeogenesis reactions. It inhibits protein kinase A activity, slows down release of glucose from glycogen and thus optimises blood sugar level. It increases the activity of enzymes promoting fatty acid formation and thus it affects energy management and supports the proper blood sugar level. Vanadium supports regeneration of pancreatic beta cells, promotes efficient functioning of the pancreas and thus the proper insulin-carbohydrate management. Its role is similar to the insulin role, as it is involved in insulin-carbohydrate management on different levels as well as supports proliferation and differentiation of cells as well as facilitates the quick growth and restoration of numerous structures in the body system. Reducing cholesterol level promotes the optimal lipid profile. It affects the concentration of 2,3- phosphoglyceric acid formed in erythrocytes and the affinity of hemoglobine to oxygen, which positively influences the efficiency of the circulatory system. The non-organic form of vanadium, vanadium sulphate, is widely a recognised chemical form of this micronutrient.

Chromium ‒ a transient metal. It is an important, but poorly absorbable mineral, which is provided in form of both organic and non-organic compounds, present in large quantities in cocoa, chocolates, wholegrain products, fishes, red meat and green vegetables, e.g. broccoli. It is present in active centres of enzymes, which is why it plays a core role in numerous metabolic processes. It increases the number of insulin receptors, improves insulin bounding with cells as well as stimulates particular kinases and reduces insulin resistance of cells. Chromium promotes glucose use by the body system, which maintains optimal blood sugar level. It is involved in insulin-carbohydrate management, which supports weight control. It promotes glucose absorption and ensures effective glycogen accumulation. It stabilises RNA, which prevents interferences in genetic material. It is involved in metabolism of carbohydrates and fats as well as optimises lipidogram. It is present in form of chromium picolinate, an organic form with chromium on oxidation stage 3+, which ensures efficient use of this micronutrient.

The complex of enzymes supporting digestion:
Invertase ‒ also known as β-fructofuranosidase or β-D-fructofuranoside fructohydrolase, commonly referred to as saccharase; an enzyme from the group of hydrolases. It is a glycoprotein catalysing the cleavage of β-D-fructofuranosidase residue from the non-reducing end of β-D-fructofuranosides. It allows for the breakdown of saccharose, raffinose, kestose, nystose, oligofructose and inulin. Among the invertase activators, the most common are magnesium, calcium and cobalt ions. Invertase is considered to be the earliest known enzyme. In 1860, M. Bertholet isolated the molecule from the yeast Saccharomyces cerevisiae. On large scale, it is obtained from yeasts by using mold and bacteria. In the industry, it is used in the production of invert sugar and artificial honey. The enzyme is valued in the prebiotic synthesis of oligosaccharides, including FIS and lactosaccharose, which allows for the development of probiotic bacteria.

Amylases ‒ is an umbrella term for several groups of enzymes: α-amylase (an endoamylase) and exoamylases. α-amylase, initially called diastase, is an enzyme randomly cleaving the α bound (1 → 4) in starch and glycogen. Products of its activity include maltose, maltotriose, glucose and α-dextrins. The enzyme does not hydrolyse the α bounds (1→6), which are characteristic for amylopectins. Amylase activators are calcium, chloride, strontium, barium, manganese and cadmium ions. In turn, its inhibitors are: iodine ions, chelators of bivalent ions, oxalate and citrate. The studies on this protein were started by Kirchhoft in 1811 and continued by Dubrunfant in 1830. It has been discovered that it can break down starch by using wheat extracts and barley malt.

Pectinases ‒ an umbrella term for enzymes breaking down complex pectin structure. They are divided by their mechanism of action into three groups: esterases, hydrolases and lyases. Pectinesterase induces deesterification of pectin methoxyl group and allows for the release of pectic acid. Polygalacturonase and polymethylgalacturonase, classified as hydrolases, cleave the α-1,4-glycosidic bounds in pectic acid and pectin. Polygalacturonate and polymethylgalacturonate lyases catalyse the breakdown of the α-1.4-glycosidic bound in pectic acid and pectin, thanks to trans-elimination and formation of unsaturated galacturonates and methyl galacturonates. About a half of pectinases comes from yeasts, the smaller part from bacteria, while only about 10% ‒ from plants and animals. They break down pectins to reducing sugars and release numerous compounds from their structures, e.g. polyphenols. Because of their properties, they are widely used in food industry, i.a. for reducing viscosity of fruit and vegetable products or improving clarification of juices and oils.

Alpha-galactosidase – or α-D-galactoside galactohydrolase. It is an enzyme classified as a glycoside hydrolase catalysing the breakdown of the α-D-glycoside bound in selected saccharides, glycoproteins and glycolipids. On industry scale, it is microbiologically obtained with participation of particular species of mold and bacteria strains. The enzyme improves the breakdown of raffinose and stachyose in the digestive tract. Such effects are particularly helpful in the diet rich in legumes containing stachyose, as they reduce bloating.

Glucoamylase ‒ also known as: α-1,4-glucan glucohydrolase and amyloglucosidase. It is an enzyme classified as amylase (exoamylase). It breaks down the 1,4- and the 1,6-glycoside bounds. It allows for the total breakdown of amylopectin and glycogen to glucose. Traditionally, the enzyme is obtained with participation of the thread-like fungi. In food industry, it is one of the oldest commonly used enzymes. It is used in processing starch and dextrin, for saccharification of this compound to glucose, which is then used for fermentation of food products.

To sum it all up, Condemned HumaSLIN is a unique product raising the effectiveness of glucose use by muscle cells. It provides different forms of carbohydrates, improves digestion and absorption of carbohydrates in digestive tract. It promotes insulin secretion, increases translocation of glucose transporter 4 (GLUT4), stimulates the receptor of insulin-like growth factor I (IGF-IR) and improves the activity of insulin receptor. By reducing the insulin resistance of myocytes, it provides glucose into muscle cells instead of fat cells. It improves insulin tolerance of myocytes, reduces fat uptake from digestive tract and stimulates the activity of triiodothyronine (T3) and thyroxine (T4) releasing energy substrates. It increases expression of receptors activated by proliferator of peroxisomes PPAR-α in the liver and PPAR-γ in the white adipose tissue, which intensifies metabolism of fats and improves lipid profile. The product affects insulin-carbohydrate and fat management and provides energy for intensive activities and muscle regeneration, which minimises energy substrates accumulation in form of stored fat. Moreover, it shows antioxidant, anti-inflammatory and detoxifying properties as well as supports many systems (cardiovascular, nervous, digestive and skeletal systems). It takes care of prostate, pancreas and liver.

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Composition

Composition

Container size: 60 capsulesDaily serving size: 2 capsulesServings per container: 30
per daily portion (2 capsules)amount%DV
Cinnamon Bark600 mg**
Gymnema Extract400 mg**
Fenugreek Extract (standardized to 50 percent saponis)200 mg**
Alpha Lipoic Acid200 mg**
Banaba Corsolic acid50 mg**
Vanadyl Sulfate20 mg**
Chromium Picolinate500 mcg**
Invertase800 su**
Amylase23,000 du**
Pectinase15 ends PGU**
Alpha Galactosidase300 AUNITS**
Glucoamylase5000 DU**

Other ingrednients

Gelatin (capsules), Rice Flour, Magnesium Stearate, Silicon dioxide.

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Fenugreek

Information

Fenugreek (Trigonella forenum) - is a herbaceous plant of the family Fabaceae. Fenugreek seeds (semen foenugraeci) reduce the level of sugar through the action of 4-hydroxyisoleucine and cholesterol in the blood. They are a stimulant of milk production, when used – production of milk increases ninefold. It is a source of diosgenin, gitogenin, yamogenien and tigogenin steroid glycosides (saponins). They can be applied internally (are protecting and anti-inflammation on the mucous membrane of the digestive system) and externally (in the inflammatory skin diseases: boils, eczema, abscesses and peptic ulcer disease).
In the sports supplementation
it is used as a source of steroid glycosides (saponin) to increase testosterone levels. Available in the form of mono-preparation supplements and numerous supplements.
Dosage: In the sports supplementation: 200-1000 mg of extract per day (once, or in two doses).


 

ALA (Alpha-Lipoic Acid)

Information


ALA (alpha-lipoic acid) is a vitamin-like substance, a metabolite of catecholamines with strong antioxidant properties, it enhances anti-free-radicals action of some vitamins (A and E). ALA is synthesized at low levels by the body. It is a component of such products as broccoli, yeast, chicken liver, spinach. In the medicine it is used in the prevention of diabetic neuropathy (tissues shows a sensitivity to the insulin hormone, and it stimulates blood sugar levels). It has a positive effect on the functioning of the circulatory system and heart by the anti-arteriosclerosis action. It improves transport of creatine. It affects the storage of glycogen in muscle and liver.
Antioxidant properties of ALA are used in sports supplementation, along with the assimilation of nutrients. ALA is found in the form of mono-formula and is a compound of multicomponent products as: amino acids, creatine nitrogen boosters, as well as insulin-like (insulin-mimetic substances).

 

Chromium Picolinate

Information

Chromium Picolinate is a complex containing trivalent chromium and picolinic acid, for greater assimilation, it has chelating and anti-inflammatory properties. Trivalent chromium is a part of the glucose tolerance factor (GTF), supporting the anabolic effect of insulin in the creatine transport into the muscle cells. Chromium is used to treat type 1 diabetes melitus, and with insulin it is involved in the metabolism of glucose it transport of protein. It is an activator of enzymes involved in the metabolism of fats and cholesterol. Chromium picolinate is used by people active beyond sports and in sports supplementation as fat burners affecting fat reduction, weight loss, as well as a compound which enhances uptake of nutrients by muscle cells and the vitamin and mineralizing supplements, available www.muscle-zone. pl

Amylase

Information


Amylase (diastase), belong to the group of digestive enzymes (from the group of hydrolases) that catalyse the decomposition of polysaccharides (starch and glycogen) into simple sugars. They are found in saliva, pancreatic juice secreted into the small intestine continuing the digestion. In nature, found in malt, cereal grains. Included in the dietary supplement in combination with the components decomposing milk sugar (lactose), lipases (enzymes that catalyse the hydrolysis decomposition of an ester bond of fat) and proteases (enzymes that catalyse the decomposition of peptide bonds, and are involved in the digestion of protein). Products containing lipase are recommended for active people using high carbohydrate diet and eating hearty meals.

 

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