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Seeking Health Optimal Liposomal Glutathione is a dietary supplement containing reduced glutathione in the highly assimilable liposomal form, at the dose of 250 mg and also vitamin B2, selenium, molybdenum and pyrroloquinoline quinone (PQQ), demonstrating synergistic effect. Optimal level of glutathione in the organism is essential to maintain oxidation-reduction potential in cells and for proper processes of detoxification.
Glutathione (GSH) is a tripeptide made of cysteine, glycine and glutamic acid. It is present in all tissues and organs of the human being. The majority is located in the liver, where it is coupled with xenobiotics (the unfamiliar substances for the organism), i.a. with free radicals, unsaturated aliphatic hydrocarbons, halogen aliphatic and aromatic hydrocarbons or epoxides. Xenobiotics coupled with glutathione are excreted with urine (after being transformed to mercapturic acids) or bile. These processes take place in the II phase of xenobiotic biotransformation. An incredibly important role in this processes is played by the group of enzymes, glutathione S-transferase (GST). These enzymes are found i.a. in the liver, kidneys, intestines and lungs. They catalyze reactions of coupling of nucleophilic glutathione with electrophilic molecules of xenobiotics, created in the I phase of biotransformation. The coupling of xenobiotics with glutathione has mainly detoxicating character. By means of this process, glutathione protects cells from the harmful effect of free radicals and other reactive molecules.
The amount of glutathione in the liver is correlated with the antioxidant capacity of this organ. Its deficiency results in non-complete metabolism of xenobiotics. A classic example is the reaction of glutathione with an active metabolite of paracetamol – N-acetyl-p-benzoquinone imine (NAPQI), which is hepatotoxic. In case of excessively low amount of NAPQI, it is not totally bound and inactivated, which results in liver necrosis.
Riboflavin (vitamin B2) is the most important B-group vitamin. The main function of riboflavin is its participation in the processes of oxidation and reduction. It constitutes a prosthetic group (non-protein enzyme part) of flavoproteins, to which there belong, i.a. NADH reductase of cytochrome C, amino acid oxidase, acetyl-CoA dehydrogenase. Acetyl-CoA dehydrogenase takes part in fatty acid metabolism. Riboflavin, by the influence on the availability of NADPH, indirectly influences the concentration of glutathione. Moreover, it is essential for biochemical changes of vitamin B6 and folic acid, for the synthesis of niacin from tryptophan and also for the proper functioning of the eyesight.
Along with vitamin B6, B12 and folic acid, riboflavin takes part in homocysteine metabolism, lowering its level. Homocysteine constitutes a marker for many diseases. Increased concentration of homocysteine may contribute to the development of many diseases, i.a. cardiovascular diseases, neurodegenerative diseases, depression and cancers. Excessively high level of homocysteine, causing oxidative stress, leads to depleting the supplies of glutathione.
Selenium is a microelement, which is essential for the proper functioning of the organism. Its proper biological role is its participation in antioxidant systems of cells and transformations of thyroid and steroid hormones. It is the component of four glutathione peroxidase isoenzymes. Appropriate concentration of selenium in blood serum conditions optimal pace of glutathione peroxidase reaction.
Selenium, as an element of the antioxidant system of the organism, takes part in metabolic transformations of each cells and decreases toxic influence of xenobiotics, especially heavy metals. Moreover, by being the component of proteins dependent on selenium, it positively influences the immune system. Deficiency of this element in the organism may lead to storing excessive amount of free radicals, which entails negative consequences for the organism.
Molybdenum is an element, appearing in the organism in trace amounts. It constitutes a cofactor for many enzymes of the organism. It is engaged in the metabolism of sulfuric compounds, the level of which has influence on the concentration of glutathione, the most abundantly appearing intracellular thiol in mammals (the substance containing sulfur).
PQQ (pyrroloquinoline quinone) is a recently discovered substance. In structure, it is close to coenzyme Q10 and vitamin K. In the era of mitochondrial medicine development, the role of PQQ is increased. This compound may have positive influence on energy processes taking place in mitochondria. It stimulates biogenesis of mitochondria in aging cells. It fights free radicals and is a strong antioxidant.
In the studies on rats, PQQ caused considerable improvement of memory. PQQ also influences the decrease of CRP level (C-reactive protein), appearing in blood under the influence of inflammation, produced in the liver, adipose cells and arterial vessels. Marking CRP level is an element of diagnostics of circulatory system diseases. Moreover, CRP is conducive to storing fatty tissue and inhibits the development of muscle tissue. Human organism cannot synthesize PQQ, therefore more and more often it is classified to the group of vitamins.
Liposomes are vesicles spontaneously appearing from phospholipids (lipids creating cell membranes). In pharmaceutics, they found application as innovative drug carriers. A substance “closed” in a liposome freely permeates biological membranes of cells, due to the similarity in structure. It is very beneficial from the point of view of bioavailability. A substance closed in a liposome is protected by this structure from oxidative degradation and demonstrates longer effect.
To sum up, Seeking Health Optimal Liposomal Glutathione is a dietary supplement containing effective ingredients supporting one of the strongest antioxidant systems of the organism – glutathione. It is especially recommended to sportsmen, people taking medicines, with lowered immunity, prone to the harmful environmental factors and toxins, i.e. heavy metals, in order to support the work of the liver and optimization of metabolic processes.
The supplement contains PQQ, which influences facilitation of lipid balance and supports fat burning. It also influences the increase of the amount of mitochondria. Therefore, it is a very good additive to supplementation for sportsmen, especially in case of endurance disciplines and people working on shaping their silhouettes.
Seeking Health is a brand which makes sure that the products it produces are characterized by high quality and purity, therefore the majority of their products is free from magnesium stearate, allergens and GMO.
This brand is directed at fighting the causes and not the symptoms, therefore the aim of the company is primarily to help in ensuring optimal work of the digestive system, among others by launching on the market high-class products supporting digestion and regenerating and nourishing the intestines, which consequently improves bioavailability of the substances beneficial to health and increases organism’s resistance to the effect of toxins coming from external environment.
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|per portion (5 ml)||amount||%DV|
|Total Carbohydrates||1 g|
|Riboflavin (as riboflavin-5-phosphate)||10 mg||769%|
|Selenium (as selenomethionine)||50 mcg||91%|
|Molybdenum (as molybdenum amino acid chelate)||50 mcg||111%|
|PQQ (pyrroloquinoline quinone)||2 mg||**|
|Phosphatidylcholine and phosphatidylethanolamine complex (from non-GMO sunflower oil)||400 mg||**|
Purified water, natural flavors , glycerin, xanthan gum, gum arabic, and potassium sorbate (0.1%).
Calories are the conventional name of the unit expressing the energy value of food, the demand and energy expenditure in human body, which in fact is 1 kilocalorie (1 kcal). 1 kilocalorie is the amount of thermal energy required to heat 1 g of water and 1 degree Celsius. The SI unit of thermal energy is 1 joule (1J), equal to approximately 4,185 kcal.
The energy value is determined by the chemical composition of the food product, by means of the so-called. physiological equivalents. Most often Atwater equivalent is used: ratio for protein 4 kcal / g, for carbohydrates 4kcal / g, and for fat - 9kcal / g.
The energy value carried out with the so-called. "Caloric bomb" is equivalent to the physical energy, amounting to 4.1 kcal per 1 g carbohydrate to 5.65 kcal per 1 g protein, 9.45 kcal per 1 g of fat.
Nutritional value, determines the suitability of a food product for realizing life functions of human, the higher it is - the higher bioavailability and lower quantity for consumption for obtaining the effects.
Carbohydrates are an essential nutrient. They are divided into: simple sugars (monosaccharides), disaccharides and polysaccharides. In terms of the human bioavailability of carbohydrates is divided into: digestabe, those which are digested in the gastrointestinal tract by transferring energy to the tissues or cells (such as starch, fructose) and indigestable, resistant to digestive enzymes (e.g. cellulose) . Affects blood glucose levels (glycemic index) and the metabolism of insulin (insulin index). The greatest demand for carbohydrates occurs before physical activity or in the middle of it, because they increase the exercise capacity, consumed after exercise provide regeneration. In the sports diet the absorption rate it is important of carbohydrates and reactions of the organism. Available in mono-preparation supplements and part of the energetic supplements, creatine stacks, nitrogen boosters.
Dosage: according to the statistics of the Institute of Food and Nutrition, carbohydrates should comprise about 50% of daily energy intake. In some diets, used residual carbohydrate consumption, not exceeding 30g / 24h.
Selenium (element, chemical symbol Se, atomic no. 34, from chalcogenide, it is present in several allotropic forms). It is supplied the body with food in the form of seleno-amino acids (selenomethionine - gathering supplies, and selenocysteine – a component of glutathione peroxidase, deiodinase and seleno-proteins). Regulates the functioning of the thyroid gland. It affects the growth and development, including sexual development (by increasing production and sperm motility). It affects the flexibility of the tissue, removes some of the toxins from the body and destroys cancer cells and reduces the severity of menopause in women. Natural products containing selenium are seafood (sea fish, oysters, bladderwrack) and vegetable products (broccoli, onions, wheat germ, bran, tomatoes) and animal products (poultry, eggs). It is also included in the composition of vitamin-mineral and mineral supplements. Selenium supplementation is recommended as a dietary supplement of active people having diet poor in this element, and as a factor increasing the body's immunity.
Selenium deficiency increases the risk of developing cancer and heart disease. Symptoms of selenium deficiency are: cardiomyopathy, growth stoppage, disorders of detoxification processes which may lead to damage to the kidneys and liver.
An excess of selenium can lead to selenosis (the disease, the symptoms are: loss of hair, nail cracks, lesions).
daily demand of selenium for pregnant women 65 mcg; nursing mothers 75 mcg; men 7 mcg.
Molybdenum (the element of the chromium groups, atomic no. 42, a chemical symbol Mo) - a trace element involved in the metabolic conversion of carbohydrates and fats and increases the absorption of iron. It is used to treat anaemia. Well affects the mood.. It is a component of many dietary supplements and in foods such as lettuce, cabbage and other leafy green vegetables, whole grains (corn, sunflower, etc.).
Phosphatidylcholine – a group of phospholipids whose molecule contains choline. It can be synthesised endogenously in the human body, is a building block of cell membranes and thus influences beneficially their functioning. Since it is found commonly in the body, phosphatidylcholine supplementation shows many health benefits.
This phospholipid has a beneficial impact on the functioning of liver tissues. It has hepatoprotective properties, consequently preventing damage to this organ caused by toxic agents, and helps treat its diseases. It reduces oxidative stress in the liver and has therefore a beneficial impact on the viability of hepatocytes.
Because of the presence of phosphatidylcholine molecules in cell membranes, whose efficiency is critical to maintaining normal neurotransmission, this compound is indicated to influence positively neuronal function. It is suggested that phosphatidylcholine may be effective especially in disorders associated with too low acetylcholine concentrations in the body.
It is also said to promote lipolysis. Such activity of this compound is observed only in topical administration. There are no reliable sources which describe that this phospholipid is capable of speeding up body fat loss in oral delivery.
Phosphatidylethanolamine (cephalin) is a phospholipids (lipid complex) from the group, which also includes phosphatidylcholine, phosphatidylinositol, occurring in the brain. They form a lecithin, or is synthesized from other phospholipids (phosphatidylserine). It affects the stability of cell membranes, by stimulating lipid profile. Ethanolamine, which is derived from phosphatidylethanolamine, affects the metabolism of fats. Phosphatidylethanolamine is a component of a nutritional, functional and vitamin supplements, usually with together other composite fats.
Sunflower oil produced from sunflower (Helianthus annus) is a source of fatty acids of Omega 6 (linoleic acid) and Omega 9 (oleic acid). It has a number of biologically active components such as carotenoids, lecithin, waxes. It is an oil rich in vitamin E content in the proper proportion in consumption in conjunction with Omega 3 and Omega 6 reduces the level of bad cholesterol (LDL). It is an antioxidant.
Sunflower oil is used in nutritional and functional supplements available at www.muscle-zone.pl
Dosage: 5 - 15 g / 24h
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