Since 2005
You are currently:
Choose language:
Need help?
Leave message
Choose language:
Select currency: $ £
Since 2005
You are currently:
  • Popular
    Poland.
    Germany.
    United Kingdom.
    Ireland.
  • A
    Australia
    Austria
  • B
    Belarus
    Belgium
    Bolivia
    Brazil
    Bulgaria
  • C
    Canada
    Chile
    Croatia
    Cyprus
    Czech Republic
  • D
    Denmark
  • E
    Estonia
  • F
    Finland
    France
  • G
    Greece
  • H
    Hungary
  • I
    Iceland
    Israel
    Italy
  • J
    Japan
  • K
    Korea, Republic of
  • L
    Latvia
    Liechtenstein
    Lithuania
    Luxembourg
  • M
    Malta
    Mexico
    Monaco
  • N
    Netherlands
    New Zealand
    Norway
  • P
    Portugal
  • R
    Romania
    Russian Federation
  • S
    San Marino
    Slovak Republic
    Slovenia
    South Africa
    Spain
    Sweden
    Switzerland
  • T
    Turkey
  • U
    Ukraine
    United States
sales@mz-store.co.uk
wysylka
Select currency: $ £
Choose language:
0 £ 0.00
Since 2005  sales@mz-store.co.uk  7767803657
N-A-G 700mg N-A-G 700mg
  • Eases pain caused by degenerative joint disease
  • Substrate for the synthesis of many biologically relevant compounds
  • May inhibit inflammatory processes of joint cartilage
  • Used to repair cartilage matrix
  • High bioavailability
  • Safe to use

Jarrow N-A-G is a dietary supplement with N-acetyl glucosamine, an aminosaccharide which is an essential precursor for the synthesis of hyaluronic acid – an important component of connective tissue.

N-Acetyl glucosamine is a compound widely used by the body because it is a building block for cartilage, connective tissue proper and functional proteins of the extracellular compartment.

Absorption, transport and excretion
N-Acetyl glucosamine is absorbed in the small intestine and is transported by the same GLUT proteins as glucose. This is probably due to the fact that this aminosaccharide is its derivative. Sources indicate that its bioavailability (during oral delivery) may reach even 90%. A low amount of administered N-acetyl glucosamine undergoes first-pass metabolism in the liver and the rest is distributed in the body and serves biological functions. The excretion of the “pure” form of this compound is observed via the intestinal route because it is subject to many metabolic processes in the body.

Biosynthesis
Apart from oral delivery, an endogenous form of this aminosaccharide is produced in tissues (mainly connective). Its precursor is glucose (which may come from food and breakdown of glycogen) which undergous enzymatic transformations and binds its parent molecule to an amine group of glutamine and acetyl-CoA. This results in the formation of N-acetyl glucosamine. The latter, also subject to a couple of biochemical reactions, can be used for building important constituents of connective tissue – glycosaminoglycans and consequently proteoglycans. These last elements of the reaction chain show a beneficial impact of this glucose derivative.

Impact on joint function
There are three types of cartilage. The one that builds the joint surface is hyaline cartilage. It is mainly composed of cells (building and remodelling cartilage) and organic extracellular matrix (among others, type I and II collagen, glycosaminoglycans and proteoglycans). This tissue is characterised by high resistance to mechanical factors due to the presence of aggrecan – the main proteoglycan composed of hyaluronic acid that make non-covalent interactions with other proteins of bone matrix, which helps it bind a large amount of water, and has a protective effect. As already mentioned, one of the elements necessary for the synthesis of hyaluronic acid is N-acetyl glucosamine which has thus an indirect protective effect on the joint surface.

The oral delivery of N-acetyl glucosamine in degenerative joint disease, which is also an inflammatory process, causes a decrease in the production of proinflammatory agents (including interleukin-1 and cyclooxygenase 2). This leads thus to reduced migration of inflammatory cells which produce enzymes that break down collagen in the cartilage during the course of a disease. This contributes to its degradation which is felt as pain during movement. In addition, supplementation may help replenish aggrecan.

Precursor for other compounds
The main task of supplemented N-acetyl glucosamine is to reduce inflammation in the cartilage. However, this compound itself is recognised by the body as a direct or indirect substrate in the synthesis of glycoproteins – mucins, integrins and serum proteins.

Mucins are found on the surface of mucous membranes of the digestive tract and the respiratory and genitourinary system. As as a component of mucus (along with water and electrolytes), they protect the body from irritants.

Integrins belong to proteins which are involved in the migration of cells during embryogenesis and also facilitate the transfer of immune cells to the inflamed area.

Serum proteins are a wide group of proteins which serve as transporters (for metal ions and drugs), have immunological properties (antibodies) and hormonal and enzymatic functions and even take part in blood clotting.

To sum up, Jarrow N-A-G is a supplement designed for individuals who want to take care of their joints. Supplementation is recommended especially for joint degenerative disease caused by inflammation because it may inhibit significantly degenerative changes in the cartilage and relieve discomfort due to pain. 

 

 

UK Stock
Since 2005
Add to Cart
N-A-G 700mg N-A-G 700mg 120 caps.
JARROW FORMULAS
£ 17.28

N-A-G 700mg 120 caps.

EU Stock

features

Strength:
Endurance:
Health:
Regeneration:

- Delivery even day after tomorrow

- Foreign shippment from £ 4.49 Every £ 65.62 reduces shipping costs by £ 2.19

You have got questions about the product

sales@mz-store.co.uk

01709231594 (mon.-fri 900-1700)

- Delivery even day after tomorrow

- Foreign shippment from £ 4.49 Every £ 65.62 reduces shipping costs by £ 2.19

You have got questions about the product

sales@mz-store.co.uk

01709231594 (mon.-fri 900-1700)

Description
  • Eases pain caused by degenerative joint disease
  • Substrate for the synthesis of many biologically relevant compounds
  • May inhibit inflammatory processes of joint cartilage
  • Used to repair cartilage matrix
  • High bioavailability
  • Safe to use

Jarrow N-A-G is a dietary supplement with N-acetyl glucosamine, an aminosaccharide which is an essential precursor for the synthesis of hyaluronic acid – an important component of connective tissue.

N-Acetyl glucosamine is a compound widely used by the body because it is a building block for cartilage, connective tissue proper and functional proteins of the extracellular compartment.

Absorption, transport and excretion
N-Acetyl glucosamine is absorbed in the small intestine and is transported by the same GLUT proteins as glucose. This is probably due to the fact that this aminosaccharide is its derivative. Sources indicate that its bioavailability (during oral delivery) may reach even 90%. A low amount of administered N-acetyl glucosamine undergoes first-pass metabolism in the liver and the rest is distributed in the body and serves biological functions. The excretion of the “pure” form of this compound is observed via the intestinal route because it is subject to many metabolic processes in the body.

Biosynthesis
Apart from oral delivery, an endogenous form of this aminosaccharide is produced in tissues (mainly connective). Its precursor is glucose (which may come from food and breakdown of glycogen) which undergous enzymatic transformations and binds its parent molecule to an amine group of glutamine and acetyl-CoA. This results in the formation of N-acetyl glucosamine. The latter, also subject to a couple of biochemical reactions, can be used for building important constituents of connective tissue – glycosaminoglycans and consequently proteoglycans. These last elements of the reaction chain show a beneficial impact of this glucose derivative.

Impact on joint function
There are three types of cartilage. The one that builds the joint surface is hyaline cartilage. It is mainly composed of cells (building and remodelling cartilage) and organic extracellular matrix (among others, type I and II collagen, glycosaminoglycans and proteoglycans). This tissue is characterised by high resistance to mechanical factors due to the presence of aggrecan – the main proteoglycan composed of hyaluronic acid that make non-covalent interactions with other proteins of bone matrix, which helps it bind a large amount of water, and has a protective effect. As already mentioned, one of the elements necessary for the synthesis of hyaluronic acid is N-acetyl glucosamine which has thus an indirect protective effect on the joint surface.

The oral delivery of N-acetyl glucosamine in degenerative joint disease, which is also an inflammatory process, causes a decrease in the production of proinflammatory agents (including interleukin-1 and cyclooxygenase 2). This leads thus to reduced migration of inflammatory cells which produce enzymes that break down collagen in the cartilage during the course of a disease. This contributes to its degradation which is felt as pain during movement. In addition, supplementation may help replenish aggrecan.

Precursor for other compounds
The main task of supplemented N-acetyl glucosamine is to reduce inflammation in the cartilage. However, this compound itself is recognised by the body as a direct or indirect substrate in the synthesis of glycoproteins – mucins, integrins and serum proteins.

Mucins are found on the surface of mucous membranes of the digestive tract and the respiratory and genitourinary system. As as a component of mucus (along with water and electrolytes), they protect the body from irritants.

Integrins belong to proteins which are involved in the migration of cells during embryogenesis and also facilitate the transfer of immune cells to the inflamed area.

Serum proteins are a wide group of proteins which serve as transporters (for metal ions and drugs), have immunological properties (antibodies) and hormonal and enzymatic functions and even take part in blood clotting.

To sum up, Jarrow N-A-G is a supplement designed for individuals who want to take care of their joints. Supplementation is recommended especially for joint degenerative disease caused by inflammation because it may inhibit significantly degenerative changes in the cartilage and relieve discomfort due to pain. 

 

 

Directions for use
Manufacturer
Reviews (0)

Composition

Composition

Container size: 120 capsulesServing size: 1 capsuleServings per container: 120
per portion (1 capsule)amount%RDA
N-Acetyl-D-Glucosamine700 mg**

Other ingrednients

Cellulose, silicon dioxide and magnesium stearate (vegetable source). Capsule consists of hydroxypropylmethylcellulose.

Similar products
Best to combine with
Unbeatable
Unbeatable Discount
DEDICATED NUTRITION

The complex of ingredients, universally promoting energy level. It increases effort abilities and strength.

£ 30.40 £ 26.03
Read more
Vital(X)Pack
Vital(X)Pack
TREC

A multi-component supplement that protects the body against the effects of nutritional deficiencies.

£ 12.03
Read more
Methyl Folate
Methyl Folate
JARROW FORMULAS

Highly bioavailable, active 4th generation folate Quatrefolic®.

£ 19.47
Read more
L-Citrulline
L-Citrulline
NOW FOODS

Citrulline supports protein metabolism and healthy immune system function

£ 27.34
Read more
Citrate Magnesium 100mg with potassium and B6
Citrate Magnesium 100mg with potassium and B6
ALINESS

Perfectly absorbable magnesium and potassium in capsules, enriched with the active form of vitamin B6.

£ 7.20
Read more
Magnesium Citrate
Magnesium Citrate
NOW FOODS

Magnesium in capsules. It supports heart function, strengthens bones, prevents cramps and improves mood.

£ 19.47
Read more

Customer service

Cooperations

Complaints

+48 510-054-586
Interested in cooperation?
mail us: sales@mz-store.co.uk JOIN MZ
Premiere in Muscle-Zone!
APOLLO'S HEGEMONY
Synephrine HCL
£ 12.90
APOLLO'S HEGEMONY
CDP Choline
£ 23.84

Reponsible for content on the site is

Supps4You LLC

16192 Coastal Hwy
Lewes, 19958 Delaware
USA

Copyright © 2018 by MZ-STORE. All rights reserved.

MZ SUPPLEMENTS LTD
FARFIELD PARK ROTHERHAM S63 5DB
shop@mz-store.co.uk +48 501 537 027>