Since 2005
You are currently:
Choose language:
Need help?
Leave message
Choose language:
Select currency: $ £
Since 2005
en
GBP
Order:£ 42.00£ 84.00£ 126.00£ 168.00
Shipping:-£ 2.00-£ 4.00-£ 6.00-£ 8.00
Login/Register sales@mz-store.co.uk  ‭+44 7507 981511‬
0 £ 0.00
Since 2005  sales@mz-store.co.uk  ‭+44 7507 981511‬
N-A-G 700mg N-A-G 700mg
  • Eases pain caused by degenerative joint disease
  • Substrate for the synthesis of many biologically relevant compounds
  • May inhibit inflammatory processes of joint cartilage
  • Used to repair cartilage matrix
  • High bioavailability
  • Safe to use

Jarrow N-A-G is a dietary supplement with N-acetyl glucosamine, an aminosaccharide which is an essential precursor for the synthesis of hyaluronic acid – an important component of connective tissue.

N-Acetyl glucosamine is a compound widely used by the body because it is a building block for cartilage, connective tissue proper and functional proteins of the extracellular compartment.

Absorption, transport and excretion
N-Acetyl glucosamine is absorbed in the small intestine and is transported by the same GLUT proteins as glucose. This is probably due to the fact that this aminosaccharide is its derivative. Sources indicate that its bioavailability (during oral delivery) may reach even 90%. A low amount of administered N-acetyl glucosamine undergoes first-pass metabolism in the liver and the rest is distributed in the body and serves biological functions. The excretion of the “pure” form of this compound is observed via the intestinal route because it is subject to many metabolic processes in the body.

Biosynthesis
Apart from oral delivery, an endogenous form of this aminosaccharide is produced in tissues (mainly connective). Its precursor is glucose (which may come from food and breakdown of glycogen) which undergous enzymatic transformations and binds its parent molecule to an amine group of glutamine and acetyl-CoA. This results in the formation of N-acetyl glucosamine. The latter, also subject to a couple of biochemical reactions, can be used for building important constituents of connective tissue – glycosaminoglycans and consequently proteoglycans. These last elements of the reaction chain show a beneficial impact of this glucose derivative.

Impact on joint function
There are three types of cartilage. The one that builds the joint surface is hyaline cartilage. It is mainly composed of cells (building and remodelling cartilage) and organic extracellular matrix (among others, type I and II collagen, glycosaminoglycans and proteoglycans). This tissue is characterised by high resistance to mechanical factors due to the presence of aggrecan – the main proteoglycan composed of hyaluronic acid that make non-covalent interactions with other proteins of bone matrix, which helps it bind a large amount of water, and has a protective effect. As already mentioned, one of the elements necessary for the synthesis of hyaluronic acid is N-acetyl glucosamine which has thus an indirect protective effect on the joint surface.

The oral delivery of N-acetyl glucosamine in degenerative joint disease, which is also an inflammatory process, causes a decrease in the production of proinflammatory agents (including interleukin-1 and cyclooxygenase 2). This leads thus to reduced migration of inflammatory cells which produce enzymes that break down collagen in the cartilage during the course of a disease. This contributes to its degradation which is felt as pain during movement. In addition, supplementation may help replenish aggrecan.

Precursor for other compounds
The main task of supplemented N-acetyl glucosamine is to reduce inflammation in the cartilage. However, this compound itself is recognised by the body as a direct or indirect substrate in the synthesis of glycoproteins – mucins, integrins and serum proteins.

Mucins are found on the surface of mucous membranes of the digestive tract and the respiratory and genitourinary system. As as a component of mucus (along with water and electrolytes), they protect the body from irritants.

Integrins belong to proteins which are involved in the migration of cells during embryogenesis and also facilitate the transfer of immune cells to the inflamed area.

Serum proteins are a wide group of proteins which serve as transporters (for metal ions and drugs), have immunological properties (antibodies) and hormonal and enzymatic functions and even take part in blood clotting.

To sum up, Jarrow N-A-G is a supplement designed for individuals who want to take care of their joints. Supplementation is recommended especially for joint degenerative disease caused by inflammation because it may inhibit significantly degenerative changes in the cartilage and relieve discomfort due to pain. 

 

 

OutOfStock
Since 2005
Notify me of availability
N-A-G 700mg N-A-G 700mg 120 caps.
Jarrow Formulas
£ 16.19

N-A-G 700mg 120 caps.

Servings: 120 caps.
1-2
Location:
EU Stock
Availability:
NONE
Working days
from the dispatch
For free shipping is missing: £ 11.00
£ 16.19With VAT

From 3 units only £ 15.86 /Units. -2%

We can let you know you when the product will be available again
Save

Customer Service

(mon.-fri 900-1700

You have got questions about the product

Description
  • Eases pain caused by degenerative joint disease
  • Substrate for the synthesis of many biologically relevant compounds
  • May inhibit inflammatory processes of joint cartilage
  • Used to repair cartilage matrix
  • High bioavailability
  • Safe to use

Jarrow N-A-G is a dietary supplement with N-acetyl glucosamine, an aminosaccharide which is an essential precursor for the synthesis of hyaluronic acid – an important component of connective tissue.

N-Acetyl glucosamine is a compound widely used by the body because it is a building block for cartilage, connective tissue proper and functional proteins of the extracellular compartment.

Absorption, transport and excretion
N-Acetyl glucosamine is absorbed in the small intestine and is transported by the same GLUT proteins as glucose. This is probably due to the fact that this aminosaccharide is its derivative. Sources indicate that its bioavailability (during oral delivery) may reach even 90%. A low amount of administered N-acetyl glucosamine undergoes first-pass metabolism in the liver and the rest is distributed in the body and serves biological functions. The excretion of the “pure” form of this compound is observed via the intestinal route because it is subject to many metabolic processes in the body.

Biosynthesis
Apart from oral delivery, an endogenous form of this aminosaccharide is produced in tissues (mainly connective). Its precursor is glucose (which may come from food and breakdown of glycogen) which undergous enzymatic transformations and binds its parent molecule to an amine group of glutamine and acetyl-CoA. This results in the formation of N-acetyl glucosamine. The latter, also subject to a couple of biochemical reactions, can be used for building important constituents of connective tissue – glycosaminoglycans and consequently proteoglycans. These last elements of the reaction chain show a beneficial impact of this glucose derivative.

Impact on joint function
There are three types of cartilage. The one that builds the joint surface is hyaline cartilage. It is mainly composed of cells (building and remodelling cartilage) and organic extracellular matrix (among others, type I and II collagen, glycosaminoglycans and proteoglycans). This tissue is characterised by high resistance to mechanical factors due to the presence of aggrecan – the main proteoglycan composed of hyaluronic acid that make non-covalent interactions with other proteins of bone matrix, which helps it bind a large amount of water, and has a protective effect. As already mentioned, one of the elements necessary for the synthesis of hyaluronic acid is N-acetyl glucosamine which has thus an indirect protective effect on the joint surface.

The oral delivery of N-acetyl glucosamine in degenerative joint disease, which is also an inflammatory process, causes a decrease in the production of proinflammatory agents (including interleukin-1 and cyclooxygenase 2). This leads thus to reduced migration of inflammatory cells which produce enzymes that break down collagen in the cartilage during the course of a disease. This contributes to its degradation which is felt as pain during movement. In addition, supplementation may help replenish aggrecan.

Precursor for other compounds
The main task of supplemented N-acetyl glucosamine is to reduce inflammation in the cartilage. However, this compound itself is recognised by the body as a direct or indirect substrate in the synthesis of glycoproteins – mucins, integrins and serum proteins.

Mucins are found on the surface of mucous membranes of the digestive tract and the respiratory and genitourinary system. As as a component of mucus (along with water and electrolytes), they protect the body from irritants.

Integrins belong to proteins which are involved in the migration of cells during embryogenesis and also facilitate the transfer of immune cells to the inflamed area.

Serum proteins are a wide group of proteins which serve as transporters (for metal ions and drugs), have immunological properties (antibodies) and hormonal and enzymatic functions and even take part in blood clotting.

To sum up, Jarrow N-A-G is a supplement designed for individuals who want to take care of their joints. Supplementation is recommended especially for joint degenerative disease caused by inflammation because it may inhibit significantly degenerative changes in the cartilage and relieve discomfort due to pain. 

 

 

Directions for use
Manufacturer
Reviews (0)

Composition

Container size: 120 capsulesServing size: 1 capsuleServings per container: 120
per portion (1 capsule)amount%RDA
N-Acetyl-D-Glucosamine700 mg**

Other ingrednients

Cellulose, silicon dioxide and magnesium stearate (vegetable source). Capsule consists of hydroxypropylmethylcellulose.

Similar products
Best to combine with
5% Nutrition
£ 32.58

Universal formulation combining in itself the most important ingredients for athletes. It contains caffeine.

Buy
Gat
£ 32.58

Pre-workout supplement that provides the effect of the strong muscle pump, increasing muscle strength and endurance.

Buy
Life Extension
£ 22.34

Methylcobalamin is the form of vitamin B12 active in the central nervous system.

Buy
Scitec
£ 20.29

A concentrated source of essential amino acids, l-citrulline. It supports physical and mental performance.

Buy
  • Popular
Alphamind
Apollo's Hegemony
£ 26.43
(23)

Extremely effective product, which ensures safe weight loss

Buy
Hi-tech
£ 40.78

An advanced pre-workout supp, intensively stimulates and promotes exercise capacity.

Buy

Latest on blog

The herbs and spices you should have in your cooking toolkit (Part 2)

The herbs and spices you should have in your cooking toolkit (Part 2)

As I was writing my previous blog on herbs and spices I quickly realised that there is so much to say about them that I needed to create a Part 1 and now a Part...

Read more
The Marathon Fuel

The Marathon Fuel

What you eat, and when you eat it, in the days before a marathon may influence your race time. Two studies show: what to eat in the days before the race. Loading...

Read more
Squat Jump

Squat Jump

The squat jump is the ultimate combination exercise and it’s a real ass-kicker to boot, taking the mechanics of a squat and adding the power component of a...

Read more
Past Failure – who can train like that?

Past Failure – who can train like that?

It seems every day someone comes along with a new and improved system of weight training scientifically designed to stimulate the muscle fibres unlike any other...

Read more
To avoid migrene, use the proper diet!

To avoid migrene, use the proper diet!

An anti-migraine diet can help people who are struggling with migraine headaches. Migraine attacks can be caused by some foods and alcohol. There is also hunger...

Read more
Selenium and coenzyme Q10 increase IGF-1 concentration

Selenium and coenzyme Q10 increase IGF-1 concentration

IGF-1 is a key signaling molecule associated with growth hormone (GH) that increases protein synthesis in skeletal muscle. Mice modified for IGF-1 expression...

Read more

Sign up for our newsletter
And receive coupons, news, special offers and much more!

Customer service

MZCatalog - recommended dietitians

MZCatalog - recommended trainers

MZCatalog - recommended clubs

Supps4You LLC
16192 Coastal Hwy Lewes, Delaware 19958
sales@mz-store.co.uk +44 7767803657