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NOW GABA Pure Powder is a mono-preparation providing a pure form of γ-aminobutyric acid (GABA) without redundant additional substances. By mitigating irritation and nervousness caused by daily stress and quietening excessively agitated organism caused by the lifestyle, it enables restoring psychological balance quickly during the day full of experiences. When taken in the evening, it quietens the organism, enabling fuller relax and better sleep during the night rest. The powdered form of the product enables easy application of the active substance by dissolving it in the small amount of water or another drink.
GABA – a shortened name of γ-aminobutyric acid, a neurotransmitter which is produced endogenously in the human organism by GABAergic neurons located in the cerebral cortex and cerebellum and then stored in synaptic vesicles of GABAergic neurons. Glutamate constitutes a substrate for a given reaction. This process, in turn, is catalyzed by glutamate decarboxylase accompanied by Pyridoxal-5-Phosphate (P5P) – an active form of vitamin B6, playing a role of the cofactor. Its internal breakdown enables the activity of the proper transaminase, also using P5P. Since for a long time GABA has been known mainly as a compound appearing in high concentrations in plants and bacteria and as a substance taking part in Krebs cycle, regardless of identifying its large amounts in the nervous systems of mammals, until the year 1960 it had been considered only a metabolite circulating in the organism. Only after this date, a few studies were published which changed the perception of GABA’s role in the organism and it was included in the group of neurotransmitter. Contrary to its starting compounds, GABA is considered a quietening neurotransmitter. The effects of its activity in the organism are visible thanks to the influence on its receptors.
GABA receptors – protein receptors, whose ligand is γ-aminobutyric acid. Due to their localization, they were classified to membrane receptors. We may differentiate two classes of these receptors: ionotropic receptors, such as GABA(A) and GABA(C) and metabotropic receptors, to which GABA(B) belongs. The most often discussed receptors are GABA(A) and GABA(B).
GABA(A) receptors – receptors classified to the group of ionotropic receptors, the regulator of which is gamma-aminobutyric acid. Their activation is caused by binding GABA to a proper sub-entity of the receptor, which enables opening the ion channel built in the membrane of a cell and transporting chloride ions to the insides of neurons. This leads to hyperpolarization of the membrane, caused by intensifying the difference of potentials at its both sides, which consequently considerably decreases effectiveness of transmission of impulses by the cells of the nervous system.
GABA(B) receptors – polypeptide receptors belonging to the group of ionotropic receptors. Their activity is presented by the activation of G protein, for the stimulation of which it is essential to bind a required ligand by a given receptor in the form of gamma-butyric acid. The effects caused by the stimulation of GABA(B) receptors take place with the engagement of potassium and calcium channels and by the influence on the excitability of adenylyl cyclase and phospholipase C. The activation of given receptors leads to inhibiting the secretion of some neurotransmitters, including noradrenaline and dopamine as well as decreasing the activity of certain secondary transmitters, i.a. cyclic AMP (cAMP).
Properties of GABA
Decreases stress and anxiety
By means of GABA(A) receptors, reducing the strength of nerve conduction, it decreases the intensity of impulses sent in response to a stress stimulus, which allows to face a stress stimulus in a calmer way. During increasing the available amount of gamma-aminobutyric acid, increased appearance of alpha brainwaves is noticeable, which is associated to relaxation of the organism with the simultaneous reduction of beta brainwaves, the increased activity of which is observed in a stressful environment. Moreover, narrowed pupils and minimal concentration of chromogranin are observed. The level of cortisol is also decreased, as a result of which we may observe decreased stress and anxiety in favor of the state of relaxation.
Improved concentration and alertness during permanent stress
The organism with long-lastingly agitated nerve transmission caused by excessive burden with stress factor distracts attention from a given activity and loses mind clarity and the related ability to properly process information. GABA, by introducing the valance between alpha and beta brainwaves, ensures conditions enabling proper course of thinking processes taking place at optimal rate, which is reflected in mind clarity, which is visible mainly in a stressful environment.
Supports maintaining good mood
By limiting intensity of signalization of stimulating neurotransmitter and at the same time by decreasing nervous tension caused by excessive number of stress factors as well as by facilitating relaxation and improving efficiency of the night rest, it supports the organism in introducing internal balance, which is considerably reflected in the improvement of psychological well-being, maintaining good mood and the creation of new powers and positive attitude to undertake new challenges.
Ensures better sleep
By quietening neurotransmission and at the same time by limiting the stimulating effect caused by the excessive activity of stimulating neurotransmitters, it quietens and relaxes the organism, preparing the organism for the night rest. Thanks to calming down the organism, it enables shortening the time of falling asleep. By creating proper environment of neurotransmission and preferring domination of a certain type of brainwaves, it ensures longer phase of deep sleep.
Improves night regeneration of the organism
By shortening the time of falling asleep and prolonging the phase of deep sleep, it ensures the conditions which are conducive to intensification of regeneration processes in the organism. Additionally, by increasing the amount of the chosen isoforms of somatotropin, it activates the pathways engaged in the renewal of protein structures.
Facilitates maintaining proper body composition
By supporting the release of somatotropin, a hormone initiating building proteins, i.a. muscle proteins, with the simultaneous intensification of the processes responsible for fat reduction, including lipolysis, as well as decreasing the concentration of cortisol, thanks to which is eliminates insulin-resistance, which improves the utilization of glucose by muscle tissue instead of storing it in the form of fat, it creates a comfortable environment for better control of body mass and creating its proper composition.
Supplementation with GABA
Taking gamma-aminobutyric acid orally from outside has been assessed as safe, even in the application of higher daily and single portions. It results from the fact that this compound does not cross the blood-brain barrier on its own, but it is taken up from the bloodstream and transported to the brain according to the needs, created as a result of the need to maintain balance of neuronal excitability and settings of the biological daily clock. The increased transport of GABA from the bloodstream to the central nervous system is noticed in the stressful moments and in the period of increased need of regeneration of the tired organism, e.g. with physical effort. It enables incredibly large comfort of supplementation and the creation of optimal effects for the organism. A daily portion which is appropriate to cause beneficial effects is 300-600 mg of the compound. When necessary, there is a possibility to safely increase the above mentioned portion to one gram or even a few grams, if it is required by the individual needs of the organism.
NOW GABA Pure Powder is a product which calms down, relaxes and reduces stress, anxiety and excessive nervousness caused by excessive intensity of life and stress of the environment. By providing a pure form of gamma-aminobutyric acid, it enables inhibition of nerve transmission according to the needs of the organism, creating at the same time mental balance, which has been previously disturbed by the importunity of stress factors. By limiting excessive neurotransmission during the day, it restores the desired psychological comfort for the further, satisfactory and undisturbed actions. In the evening, in turn, it causes relaxation and allows to prepare the organism for a night sleep and introduce it in a better-quality sleep. The pure form of the compound, without redundant additives, allows its better assimilation with water or another favorite drink.
The comfortable form of the product allows to individually adjust the dose of the supplement. I recommend starting from the dose suggested by the producer and further modification according to the experiences. Some sources suggest the doses even up to 5000 mg of GABA per day (especially in order to influence metabolism of the growth hormone).
Now Foods is a company with years of experience in the industry that offers a wide range of nutrients and dietary supplements. Brand is known for its high-quality products designed for hair and nails and supplements supporting the immune system. The offer includes the antioxidant supplements, antibacterial supplements, reducing appetite supplements, products supporting the reduction of body fat and improving digestion. All products are made from natural ingredients.
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GABA (gamma amino butyric acid) is an amino acid neurotransmitter fulfilling the role of suppressing, of which precursor is the glutamate (neurotransmitter) excitatory neurotransmitter. Reduces psychophysical tension and cortisol levels, enhances the synthesis of growth hormone having anti-catabolic and regenerating properties. Higher need for GABA by the organism occurs with overtraining, mental exhaustion of the body (stress, depression). Supplementation sports and for physically active people recommended after and during intense exercise. GABA is available in the form of mono-preparation supplement and multicomponent formulations to support the regeneration of the night regenerateion and relaxation of the nervous system.
Dosage: 0,5-3g daily approx. 1 hour before bedtime (single dose, customarily in supplementation).
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