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|Servings: 30 caps.|
Life Extension NAD+ Cell Regenerator™ with Resveratrol is a unique formula with promotes longevity and reduces negative effects of the body’s ageing. It helps maintain youthfulness, fitness and mental health and adds energy and vitality. It may reduce the incidence of age-related diseases.
The supplement is based on Niagen®, a patented derivative of vitamin B3, and resveratrol. For even better efficacy, the product has been fortified with a blend of ingredients of plant origin which have synergistic effects with resveratrol, stimulate its activity and slow down its metabolic breakdown.
Nicotinamide riboside is a niacin derivative. A natural source of this compound is, among others, brewer’s yeast and cow’s milk. It is a precursor to two key coenzymes in the body (NAD and NADP) which are critical to cellular respiration and facilitates the conversion of consumed food into energy essential to your life.
Resveratrol is a natural chemical compound which belongs to polyphenols. It is a strong antioxidant, has a cardioprotective effect and may extend your lifespan and slow down ageing owing to its ability to activate the SIRT1 protein.
Quertecin is a flavonoid that is characteristic of some fruits and vegetables. It has anti-inflammatory and antioxidant properties. It acts in synergy with resveratrol and also increases its bioavailability and prolongs its activity in the body (inhibits the activity of enzymes responsible for converting resveratrol into biologically inactive metabolites).
Pterostilbene is a phytoalexin that is structurally similar to resveratrol. However, it has better absorption and is characterised by greater pharmacological effects due to the content of methoxyl groups. It has a very beneficial effect on metabolic functions owing to the ability to modulate gene expression.
Fisetin is a chemical compound from a group of polyphenols, a type of pigment responsible for the colour of many fruits and vegetables. It is an effective activator of the longevity gene (SIRT1) and shows also strong neuroprotective properties. It has synergistic effects with resveratrol and protects its from breakdown in the body.
Red grape and wild blueberry blend is a rich source of polyphenols, anthocyanins and oligomeric proanthocyanidins (OPC). They are one of the strongest known antioxidants and are used as a general preventive measure and for cardiovascular prevention.
The supplement prevents drops in energy and promotes youthful vitality regardless of age. Nicotinamide riboside in this formula is a precursor to nicotinamide adenine dinucletodide (NAD+) which is critical to the body’s energy balance. A decrease in NAD+ levels, which is characteristic of an ageing body, leads to metabolic disorders manifested by fatigue and lack of motivation. It has been demonstrated that nicotinamide riboside helps replenish NAD+ in cells and stimulates mitochondrial activity. Mitochondria are the most important “energy centres” in the body and their number and condition influence our health, mental and physical efficiency and life expectancy.
The supplement may slow down ageing. This process depends greatly on the activity of proteins known as sirtuins. By modulating their activity, it is possible to delay ageing and extend lifespan. It has been believed so far that resveratrol is the most effective stimulator of SIRT1 and SIRT3. However, sirtuins activated by resveratrol need NAD+ as an energy substrate. NAD+ levels can be increased easily by enriching your diet with nicotinamide riboside.
The supplement promotes cardiovascular health. Polyphenols in this formula have scientifically proven efficacy in preventing cardiovascular diseases. The most recognised representative of this group is resveratrol and the structurally similar pterostilbene. There is a lot of talk about pro-health properties of anthocyanins and oligomeric proanthocyanidins (OPC) extracted from berries. They are very strong antioxidants which help regulate cholesterol levels, prevent blood clotting, normalise blood pressure and improve the condition of blood vessels.
The supplement demonstrates neuroprotective properties and strengthens cognitive functions. Scientists have proven that NAD+ levels decrease gradually with age, consequently impairing efficiency and brain performance. By providing the body with enough substrate for NAD+ production, we can preserve healthy cognitive functions till old age. In addition, compounds from this product, prevent beta-amyloid accumulation in the brain and protect neurons against degeneration. This means that they eliminate the main causes of Alzheimer’s disease.
The supplement helps maintain genome stability and has anti-cancer properties. Cells’ DNA is exposed everyday to damage by various external factors (UV rays, pharmaceuticals, toxins) and internal ones (excessive free radicals). If damaged DNA is not repaired in time, it can cause cell death or trigger carcinogenesis. Nicotinamide riboside from this supplement functions as a precursor to NAD+ and substrate for PARP-1. NAD+ stabilises genome and increases the resistance to factors which damage DNA. The enzyme PARP-1 detects DNA abnormalities and stimulates repair processes within the damaged area.
To sum up, Life Extension NAD+ Cell Regenerator™ with Resveratrol is an effective supplement with health-promoting and antiageing properties. It may improve life comfort of individuals who feel negative consequences of passing time. It is also an excellent preventive agent for diseases of affluence.
The supplement is based on natural compounds and safe even for prolonged use. Due to the content of nicotinamide riboside, it will not be suitable for individuals with liver dysfunction only.
There is no risk of a so-called Niacin flush while taking supplements with nicotinamide riboside because it occurs only when you supplement with vitamin B3 as nicotinic acid.
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|per portion (1 capsule)||amount||%DV|
|NIAGEN® Nicotinamide Riboside||250 mg||**|
|Quercetin (as quercetin dihydrate)||150 mg||**|
|Trans-Resveratrol [from Japanese knotweed (root)]||100 mg||**|
|Red grape (fruit) and wild blueberry (fruit) blend||40 mg||**|
|[providing polyphenols, anthocyanins, OPCs]|
|Fisetin [from wax tree extract (stem)]||10 mg||**|
|Trans-Pterostilbene (from pTeroPure®)||0.5 mg||**|
Vegetable cellulose (capsule), microcrystalline cellulose, silica, vegetable stearate, maltodextrin.
Niagen (nicotinamide riboside) is a derivative of vitamin B3, required for many many metabolic processes of NAD+ which is involved in many metabolic pathways of our body and is of utmost importance for its normal functioning. NAD+ has an impact on the function of mitochondria, namely cell organelles which are very active when doing sport. It regulates energy metabolism and is vital to normal functioning of the nervous system.
Since niagen helps increase directly NAD+ levels in the body, it contributes to the activation of more proteins – sirtuins which are essential to processes that affect the lifespan. Because of that, this compound may delay ageing of the body. SIRT proteins are also capable of repairing damaged DNA or regulating transcription.
According to scientists, this compound may be used in the future to regenerate the body after radiotherapy and for neurological disorders (Alzheimer’s disease) and kidney and liver diseases.
Quercetin - flavonoid glycoside, which is a natural pigment occurring in plant foods (fruits, vegetables and herbs). A particularly rich source of quercetin are apples, onions and tea. By inhibiting the hyaluronidase enzyme, it protects hyaluronic acid against returning into its monomer. It has a beneficial effect on the cardiovascular system, strengthens the walls of blood vessels. It is an antioxidant. Causes a decrease in histamine showing an antiallergic action. It has anti-inflammatory potential. It is used to treat asthma, diabetes and for weight loss. The supplementation occurs only in combination with hesperidin, rutin and ascorbic acid, in health-related programs, supporting the immunity of the body in the form of creatine stacks and no-boosters. Available at the www.muscle-zone.pl
Dosage: the lack of standards for daily consumption recommended: as customary taken in sport
Resveratrol - is a natural phenolic, compound produced as an antagonist of pathogens. It can be found, among others, in grapes, peanuts and red wine. It is oxidizing, preventing forming of free radicals of oxygen, supports the operation of systems: the hormone (binds to receptors of estrogenic and reduces the activity of the enzyme 5-alpha-reductase, is an aromatase inhibitor), blood (oxygenation of organism), and immune. In the sports supplementation used in silhouetted disciplines due to reduce of fat tissue. It is a component of supplements to support the functioning of the endocrine system (increases testosterone levels, lowering estrogen levels), antioxidant complexes and detoxifying the organism supplements, available at www.muscle-zone.pl
Dosage: the lack of strict standards of daily consumption.
Pterostilbene is a modified form of resveratrol which is better absorbed by the body. It is a compound which may have a beneficial impact on detoxification process of the body, prevents the development of cancer and influences mitochondrial function, fat burning process and the function of nerve and muscle cells, which may be important to athletes.
Studies have shown that pterostilbene is a strong antioxidant and that is why it may help reduce oxidative stress in the body caused by oxygen free radicals. It inhibits their oxidation by increasing the secretion of antioxidant enzymes.
Scientists have also demonstrated that pterostilbene may have a major anti-cancer effect. It may inhibit the proliferation of melanocytes and block enzymes which activate carcinogens. It probably blocks the formation of prostaglandin E2 (PGE2) – a hormone involved in the initiation of an inflammatory response. Because of that, we can presume that it will be an effective anti-inflammatory agent.
According to some sources, pterostilbene may stimulate the activity of fat-sensing complexes (caloric restriction), which results in a decrease in blood lipid and sugar levels and thus promotes body fat reduction. Results of one study have also shown that pterostilbene helps increase muscle gain and strength because it promotes anabolic processes.