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d-Limonene 500mg d-Limonene 500mg
  • Has a soothing effect on reflux oesophagitis
  • May help relieve tension caused by stress
  • Excellent bioavailability in oral delivery
  • May inhibit cancer development
  • May show anti-inflammatory properties
  • Isolated from orange peel

Jarrow Formulas d-Limonene is a dietary supplement with d-Limonene – an organic compound classified as a terpene, which is a natural component of citrus essential oils (including orange, mandarin, lime, lemon and grapefruit).

D-Limonene found in the formula is steam-distilled from orange peel and purified.

D-Limonene is a compound isolated from citrus. Due to a pleasant, citrus fragrance, it is used as an aroma and flavour enhancer. As it turns out, d-Limonene may also be used to support the treatment of some diseases.

It exerts thus a soothing effect on reflux oesophagitis and supports also liver function. It has been shown to be effective in the prevention and treatment of cancer.

Chemical structure and metabolism
Limonene belongs to a group of organic compounds known as monoterpenes which give plants their fragrance properties. Their name comes from terpentine because they have a similar chemical structure and are produced by plants. They comprise an isoprene unit which is also a component of, among others, vitamin A or cholesterol.

There are three main modes of delivery of limonene – oral, inhalation and percutaneous. The first one is characterised by almost complete bioavailability whereas the other ones are of more marginal importance. After reaching the bloodstream, the compound enters the liver where it is used by enzymes from the CYP2C family for the formation of its metabolites – derivatives of perillic acid, distributed in tissues and then excreted via the kidneys.

Modification of the cell cycle
The cell cycle is the series of events in a cell which lead to its division. It comprises interphase, which is divided into a few phases (G1, replication, G2), and division phases whose smooth transition is controlled by cyclins and cyclin-dependent kinases (CDKs).

Cancer processes result from the loss of control of the cell cycle which leads to, among others, uncontrolled cell division. It is reported that Limonene and its metabolites may stabilise cell signalling pathways.

They include a p-21 dependent pathway whose activation (facilitated by monoterpene) helps halt the cycle at the G1 phase and repair DNA damage.

The second one are TGF-β signalling pathways. This cytokine has immunosuppressive properties and its impaired secretion leads to the development of autoimmune diseases and cancer. There are a few pathways which rely on the transduction of signals between a dozen proteins (one protein affects the other, the second one affects the next one, until the desired effect is reached) and lead to the expression of genes which initiates, among others, the apoptosis (promoting limonene activity) or proliferation of different cells (e.g. related to cancer).

In addition, Limonene also interferes with the pathway of mevalonic acid at the stage of the formation of geranyls and farnesyls that bind to proteins and consequently help them reach the cell membrane and serve their receptor function (transmission of signals inside the cell). The lack of binding of this group makes it impossible to “attach” receptors to the membrane and precludes the transduction of signals, which is a key element of the treatment of some types of cancer.

Impact on gastrointestinal health
Since limonene is a chemical compound structurally similar to cholesterol, it has been used clinically to dissolve cholesterol bilestones.

Taking into account its soothing effect, it was used to relieve heartburn and gastrointestinal reflux disease. In terms of anti-cancer properties, it has been demonstrated that monoterpene had a cytotoxic effect on stomach cancer caused by a particular cell line by inducing its apoptosis.

It is stipulated that supplementation with this compound may aid in the treatment of non-alcoholic fatty liver disease (caused by, among others, obesity and diabetes) – a decrease in lipid droplet concentration inside the hepatocytes normalises liver function.

Other properties of Limonene
It has been shown in clinical studies that the compound may reverse considerably cancerous changes in women with breast cancer (this is associated with the activation of the pathway which involves TGF-β and degradation of IGF-II as an agent stimulating the growth of cancer).

It is also possible that limonene has an anti-inflammatory effect and may also reduce stress by affecting the balance between the sympathetic and parasympathetic nervous system, releasing significantly tension in the first one.

Jarrow Formulas d-Limonene is a supplement designed mainly for individuals who suffer from pain associated with hyperacidity and want to promote a healthy digestive system. It may be used also as a preventive measure due to its anti-cancer effect.

 

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Since 2005
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d-Limonene 500mg d-Limonene 500mg 120 softgels
Jarrow Formulas
£ 8.26

d-Limonene 500mg 120 softgels

Servings: 120 softgels
1-2
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Availability:
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For free shipping is missing: £ 64.00
£ 8.26With VAT
£ 0.07 / serving

From 3 units only £ 8.09 /Units. -2%

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Description
  • Has a soothing effect on reflux oesophagitis
  • May help relieve tension caused by stress
  • Excellent bioavailability in oral delivery
  • May inhibit cancer development
  • May show anti-inflammatory properties
  • Isolated from orange peel

Jarrow Formulas d-Limonene is a dietary supplement with d-Limonene – an organic compound classified as a terpene, which is a natural component of citrus essential oils (including orange, mandarin, lime, lemon and grapefruit).

D-Limonene found in the formula is steam-distilled from orange peel and purified.

D-Limonene is a compound isolated from citrus. Due to a pleasant, citrus fragrance, it is used as an aroma and flavour enhancer. As it turns out, d-Limonene may also be used to support the treatment of some diseases.

It exerts thus a soothing effect on reflux oesophagitis and supports also liver function. It has been shown to be effective in the prevention and treatment of cancer.

Chemical structure and metabolism
Limonene belongs to a group of organic compounds known as monoterpenes which give plants their fragrance properties. Their name comes from terpentine because they have a similar chemical structure and are produced by plants. They comprise an isoprene unit which is also a component of, among others, vitamin A or cholesterol.

There are three main modes of delivery of limonene – oral, inhalation and percutaneous. The first one is characterised by almost complete bioavailability whereas the other ones are of more marginal importance. After reaching the bloodstream, the compound enters the liver where it is used by enzymes from the CYP2C family for the formation of its metabolites – derivatives of perillic acid, distributed in tissues and then excreted via the kidneys.

Modification of the cell cycle
The cell cycle is the series of events in a cell which lead to its division. It comprises interphase, which is divided into a few phases (G1, replication, G2), and division phases whose smooth transition is controlled by cyclins and cyclin-dependent kinases (CDKs).

Cancer processes result from the loss of control of the cell cycle which leads to, among others, uncontrolled cell division. It is reported that Limonene and its metabolites may stabilise cell signalling pathways.

They include a p-21 dependent pathway whose activation (facilitated by monoterpene) helps halt the cycle at the G1 phase and repair DNA damage.

The second one are TGF-β signalling pathways. This cytokine has immunosuppressive properties and its impaired secretion leads to the development of autoimmune diseases and cancer. There are a few pathways which rely on the transduction of signals between a dozen proteins (one protein affects the other, the second one affects the next one, until the desired effect is reached) and lead to the expression of genes which initiates, among others, the apoptosis (promoting limonene activity) or proliferation of different cells (e.g. related to cancer).

In addition, Limonene also interferes with the pathway of mevalonic acid at the stage of the formation of geranyls and farnesyls that bind to proteins and consequently help them reach the cell membrane and serve their receptor function (transmission of signals inside the cell). The lack of binding of this group makes it impossible to “attach” receptors to the membrane and precludes the transduction of signals, which is a key element of the treatment of some types of cancer.

Impact on gastrointestinal health
Since limonene is a chemical compound structurally similar to cholesterol, it has been used clinically to dissolve cholesterol bilestones.

Taking into account its soothing effect, it was used to relieve heartburn and gastrointestinal reflux disease. In terms of anti-cancer properties, it has been demonstrated that monoterpene had a cytotoxic effect on stomach cancer caused by a particular cell line by inducing its apoptosis.

It is stipulated that supplementation with this compound may aid in the treatment of non-alcoholic fatty liver disease (caused by, among others, obesity and diabetes) – a decrease in lipid droplet concentration inside the hepatocytes normalises liver function.

Other properties of Limonene
It has been shown in clinical studies that the compound may reverse considerably cancerous changes in women with breast cancer (this is associated with the activation of the pathway which involves TGF-β and degradation of IGF-II as an agent stimulating the growth of cancer).

It is also possible that limonene has an anti-inflammatory effect and may also reduce stress by affecting the balance between the sympathetic and parasympathetic nervous system, releasing significantly tension in the first one.

Jarrow Formulas d-Limonene is a supplement designed mainly for individuals who suffer from pain associated with hyperacidity and want to promote a healthy digestive system. It may be used also as a preventive measure due to its anti-cancer effect.

 

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Composition

Container size: 120 softgelsServing size: 1 softgelServings per container: 120
per portion (1 softgel)amount%RDA
d-Limonene (from orange peel oil)500 mg**

Other ingrednients

Softgel consists of gelatin, glycerin and water, with caramel and carob (as a light barrier).

No wheat, no gluten, no soybeans, no dairy, no egg, no fish/shellfish, no peanuts/tree nuts.

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