• Standardized Cissus quadrangularis extract
• Guaranteed 40% bioactive ketosterones
• Strong anti-inflammatory and analgesic activity
• Accelerates bony healing
• Supports treatment of sports injuries
• Reduces the risk of developing osteoporosis
• Stimulates regeneration of connective tissue
• Perfect for physically active people
• Promotes muscle mass growth
• Strengthens motor system

PURE Cissus is a dietary supplement that includes a highly standardized extract from the African plant Cissus quadrangularis, containing 40% bioactive ketosterones.

The product helps to improve the condition of the musculoskeletal system, strengthens the skeleton, tendons, and ligaments. It has a strong anti-inflammatory and analgesic effect. It is highly recommended for people recovering from injuries or fractures. It is also used in the prevention of sports injuries and osteoporosis. An interesting feature of the supplement’s bioactive substance is its anabolic activity, valued by athletes working on their body definition.

Cissus quadratus (Cissus quadrangularis) is a plant widespread in Africa and partly also in Asia. Indigenous people have been using it for centuries to alleviate dysfunctions of the musculoskeletal system and to relieve pain in the joints. In phytotherapy, all parts of the plant are used. The root, stem, and leaves are characterized by a high content of ascorbic acid, carotene, and flavonoids. They also provide unique compounds belonging to the group of tetracyclic triterpenoids, so-called ketosteronów.

Strengthening musculoskeletal system
One of the most popular uses of Cissus extracts is the prevention and treatment of the motor system dysfunctions. The bioactive substances of the plant display a strong anti-osteoporotic effect, facilitate wound healing, promote closing up of bone cracks and accelerate the fracture healing. They have s strong anti-inflammatory activity, so they are also helpful in case of joint or tendon disorders, such as Achilles tendonitis or bursitis.

The mechanism of action of the substances contained in Cissus encompasses few important elements. They stimulate bone metabolism, as well as the activity of the most important connective tissue cells and enhance the uptake of minerals (especially calcium) by osteoblasts. Consequently, the process of restoration of the correct bone composition, disturbed by injury (cracking, fracture), is quicker. In addition, Cissus stimulates the activity of fibroblasts, which are responsible for the synthesis of collagen fibers and chondroblasts, involved in the formation of cartilage.

Faster pace in healing of broken bones under the influence of Cissus extracts was observed in rodents. Animals that received Cissus extracts usually recovered in less than 4 weeks, while a group treated with standard methods needed 6 or more weeks.

Prevention of osteoporosis
Cissus can be recommended to women during menopause, when the risk of developing osteoporosis increases rapidly. Traditional pharmacological treatments, especially hormone-based, have a fairly high risk of side effects. Yet the research shows that taking Cissus extracts brings effects comparable to estrogen therapy. In both cases the same increase in bone thickness and improvement in their mineral density were reported. Importantly, when supplementing with Cissus extracts, in none of the tested women occurred side effects.

Analgesic and anti-inflammatory activity
Indigenous peoples of Africa and Asia have been using Cissus for centuries to relieve pain in the osteoarticular system. Scientists studying the plant have proved that the potency of its action can be compared to that exhibited by pharmacologic drugs from the NSAID group. In rodent tests, it was showed that Cissus can inhibit both neurogenic pain caused by nerve damage and pain caused by inflammation resulting from injury.

The bioactive compounds isolated from the plant have the ability to regulate the production of inflammatory substances, such as TNF-α factor or interleukins IL-1 and IL-6. In addition, they have a significant antioxidant potential, and as is well known, the excess of free radicals closely correlates with intensifying of inflammation.

Cissus for physically active people
The fact is that motor system of physically active people is exposed to an extremely heavy load. As a result, the risk of injury increases. By strengthening the osteoarticular system, Cissus can reduce the risk of sports injury and reduce the possible pain caused by overloading.

An interesting feature of the plant is its anabolic potential, which can also be used to in chasing dreamt silhouette. It appears that ketosterones stimulate the activity of systemic anabolic hormones, which may considerably facilitate building lean mass and loss of body fat.

In summary, PURE Cissus is an excellent solution for athletes, whose dysfunctions in the motor system are the result of excessive loads from intense physical activity. It is also a great alternative for women during menopause, at high risk of osteoporosis. Supplements can also be used by convalescents recovering after bone fractures.