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Apollo's Hegemony Acticissus is a dietary supplement containing the patented ActiCissus® extract from veld grape, standardized for the content of 10% ketosteroids and 1% calcium. The extract was developed by the Sabinsa brand. The product supports the osteoarticular system health, shows analgesic properties and supports regeneration after the injuries.
The veld grape (Cissus quadrangularis) is a plant that has been used in a natural medicine for many years. Its extracts show a lot of pro-health properties. The cissus gained popularity in the phytotherapy of musculoskeletal disorders thanks to the ability to accelerate the regeneration of bones and joints by means of many mechanisms. In addition, the plant has documented anti-inflammatory, analgesic and antioxidant properties. It also supports the reduction of the excessive body weight and fat, supports the fight against the metabolic syndrome, overweight and obesity.
Chemical composition of cissus quadrangularis
Cissus has a wide range of active compounds that determine the unique action of the plant. They are primarily classified as tetracyclic triterpenoid ketosteroids, as well as flavonoids, vitamins C and E and calcium.
Influence on the musculoskeletal system
Cissus is helpful both as an element of prophylaxis and phytotherapy of osteoporosis - a disease involving the reduction of the bone mass, which increases the susceptibility to fractures and injuries. It was shown that the plant extracts increase bone mineralization, through improving the calcium uptake and by reducing the level of proinflammatory cytokines, including IL-1 and IL-6, involved in the bone remodeling process and increasing their resorption.
In an animal study, the ability of the cissus extract to alleviate the induced chondrocyte lesions (cartilage cells) and to stimulate the cell growth and division was demonstrated. Cissus also affects the production of collagen by fibroblasts. In addition, meta-analyzes of studies conducted on humans have shown that the plant positively affects the regeneration of bone tissue. Regular supplementation with cissus extracts can shorten the time needed to heal a broken bone.
Cissus in sports supplementation
Thanks to the analgesic and anti-inflammatory activity and the impact on the joint health, cissus is particularly recommended in sports supplementation. It is helpful in the joint pain caused by overload, allowing faster recovery and supporting mobility of the motor system. In addition, cissus effectively supports the post-workout recovery.
Help in obtaining a healthy body weight
Cissus is also helpful in achieving the dream figure. The ketosteroids present in the plant have an anabolic effect, thanks to which they promote building of the muscle mass. In addition, cissus supports the reduction of adipose tissue - it has been shown (in an animal study) that taking the extract from the plant caused a decrease in the body weight and adipose tissue as well as a decrease in the adipocytes size.
In vitro studies have shown that the active ingredients of the plant have the ability to inhibit the pancreatic lipase activity, they affect the regulation of adipose tissue function and gene activity associated with the lipogenesis processes.
In conclusion, Apollo's Hegemony Acticissus is a natural and safe help for the osteoarticular system. The product is recommended especially for the athletes and physically active people to relieve injuries and to speed up regeneration, for women during menopause to protect against osteoporosis, for the elderly to support the health of joints and for convalescents after the injuries and broken bones.
For an optimal performance, preparations containing cissus quadrangularis should be regularly supplemented for a period of minimum 6-8 weeks.
In numerous studies on the safety of the plant, it was shown that even very high doses of the extract (5000 mg / kg) did not give noticeable side effects. The standard amount of the extract in dietary supplements is much smaller, which indicates a high safety profile of preparations based on cissus.
Apollo’s Hegemony is a manufacturer of dietary supplements whose composition is based on the latest scientific research and experience. The company is constantly expanding its range of products and taking care that they are of top quality.
It offers formulations which have multiple effects on the body and those with more targeted effects – e.g. boosting alertness and focus, increasing the tolerance to stress, promoting peaceful sleep and maintaining the health of the liver and adrenal glands.
Dietary supplements by Apollo’s Hegemony are effective owing to carefully selected composition which comprises the most potent forms and their precise doses. What is more, herbal supplements contain standardised extracts.
All products of this brand comply with good manufacturing practices (GMP) and their ingredients are vegan and vegetarian friendly.
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Microcrystalline cellulose, rice flour, hypromellose (capsule shell).
The product has not been tested for substances banned by the World Anti-Doping Agency (WADA).
Cissus quadrangularis (Asthisamharaka) - a plant originating from India, a relative of vines. Used in ancient medicine as an anti-inflammatory medicament and bringing the regeneration of bone tissue, it is currently recommended in cases of osteoporosis as well as supporting the bones after sports injuries. It contains a number of active substances (including triterpenoids, alpha-sitosterol). Inhibits the activity of cortisol and affects the development of muscle tissue.
Calcium (element chem. symbol Ca, atomic no. 20, the group of alkaline earth metals) is the basic building substance of bones and teeth, in which stored is 99% of the element, in the form of hydroxylapatite. When building bones and teeth, phosphorus is very important in the right proportion. It is a base-forming element and activator of many enzymes (ATPase) necessary to release the energy of ATP. It has a significant effect on blood clotting and regulates blood pressure and neuromuscular conductivity. Thanks to the reduced permeability of cell membranes, it soothes the symptoms of food allergies. Calcium is actively involved in the metabolism of iron interacts with vitamins A, C and D and phosphorus, magnesium. Natural source of calcium are animal products (dairy products, sardines, salmon, sprats eaten with bones) and plant products (nuts, soybeans, sunflower seeds). Absorption takes place in the small intestine (less in the colon), it has an effect on the level of lactose, insoluble fibre, organic acids, alkalinity (low pH). The best absorption have organic compounds (lactates, amino acid chelates etc.). Obstructing the absorption of calcium is caused by: phytic acid and oxalic acid as well as excess fat. Scientific studies have confirmed that the combination of calcium, magnesium, boron and vitamin D in dose 3 mg / 24h effectively prevent osteoporosis. Supplements on the market are both mono-preparation supplements (enriched with vitamin D3) and multi-component supplements, available at www.muscle-zone.pl.
Calcium deficiency disorders manifested in the construction of the bones (osteoporosis) and iron metabolism. The symptoms are: rickets, cramps and muscle tremor, osteoporosis.
Excess resulting from an overdose of calcium supplements containing vitamin D3 for children and adults overdose of calcium (hypercalcemia). Symptoms of hypercalcemia are: lack of appetite, vomiting and constipation.
The dosage administered in various publications are inconsistent: 800 - 1000 mg / 24 h (100 - 500 mg / 24h)
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