• Stabilized S-adenosylmethionine (SAMe) in capsules
• Nervous system support
• Beneficial effect on mental well-being
• Improvement of cartilage tissue metabolism
• Cognitive enhancement
• Joint health support

NOW® SAMe is a dietary supplement that contains a stable and highly bioavailable form of S-adenosylmethionine (SAMe). The preparation comes in the form of easy-to-swallow capsules, also suitable for vegetarians or vegans.

S-adenosylmethionine (SAMe) is adenosine- and methionine derivative, which is formed in the human body with the help of vitamins B9 and B12. It is responsible for the proper course of key biochemical reactions and is one of the most important substrates in methylation processes.

The preparation contains a stable form of SAMe, derived from S-adenosyl-L-methionine disulfate tosylate. It does not require the use of a special coating resistant to gastric juice and thus it could be enclosed in easy-to-swallow capsules. Note that S-adenosyl-L-methionine belongs to unstable chemical substances and is easily degraded, which is quite a challenge for manufacturers of dietary supplements and therapeutic products.

SAMe supports the functioning of the nervous system. It shows an antidepressant effect and may also prove helpful in mild cognitive impairment. It has a large impact on the formation of key neurotransmitters, including serotonin, dopamine, and noradrenaline. Besides, being a versatile donor of methyl groups, SAMe is involved in the synthesis of phosphatidylcholine, which enters the structure of cell membranes and is a key component of nerve tissue.

SAMe is of great importance for bone and joint health. It is used in the treatment of osteoarthritis, arthritis, or osteomyelitis. It exerts strong anti-inflammatory and analgesic properties and has a beneficial effect on joint mobility. Scientists point to several potential mechanisms responsible for these effects. They include, e.g. inhibiting the production of inflammatory mediators, increasing glutathione synthesis, maintaining normal DNA methylation, as well as direct or indirect effects on the synthesis and metabolism of articular cartilage and regeneration of cartilage tissue.

In summary, NOW® SAMe is a preparation that contains a compound that plays many important roles in the body. It can be used to improve the mood and mental well-being as well as the condition of the osteoarticular system.