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P5P PLUS is a dietary supplement which contains pyridoxal-5-phosphate (P-5-P), metabolically active form of vitamin B6, which does not have to undergo initial transformations in the liver, in contrary to other forms. Vitamin B6 in form of a coenzyme is quickly absorbed by the body system, and the presence of vitamin B2 and magnesium increases bioavailability and enhances preparation action.
Vitamin B6 is one of 8 B-vitamins which is involved in many enzymatic reactions, including metabolic processes. It supports transformations of proteins, fats and carbohydrates, participates in gluconeogenesis and glycogenolysis as well as promotes the proper use of energy obtained from food. Pyridoxine is also responsible for the development of the nervous system and the proper functioning of the cardiovascular system.
Increased demand for the vitamin is observed in people with impaired kidney functions (patients on dialysis, after kidney transplantation), autoimmune diseases (Crohn’s disease, ulcerative colitis, coeliac disease and rheumatoid arthritis), using particular drugs (e.g. isoniazid, penicillamine and oral contraceptives) and alcoholics.
The consequences of vitamin B6 deficiency
Symptoms of vitamin B6 deficiency include mainly dermatological lesions – pruritus, rash, cracking corners of the mouth and inflammation of tongue mucous membrane. Other symptoms are muscle weakness, depressive symptoms, concentration problems, temporary memory loss, weak immunity and irritation. Possible are also very sensitive hearing and anaemia caused by impaired haem synthesis.
Support for the cardiovascular system
Vitamin B6, together with folic acid and vitamin B12, affects reduction in homocysteine level, which is an amino acid whose high level is one of the risk factors of cardiovascular diseases. Moreover, it is a coenzyme for an enzyme involved in haem synthesis, which is 5-aminolevulinic acid synthase, which is why it supports haemoglobin production and its ability to bind with oxygen.
Improvement in cognitive skills
Vitamin B6 is essential for the proper functioning and development of the brain, prevents premature nervous cells ageing and participates in neurotransmitters biosynthesis (serotonin and dopamine), so that it improves mood and cognitive skills. Its deficiency results in neurological disorders, which are caused by i.a. improper synthesis of catecholamines, decline in gamma-aminobutyric acid (GABA) and impaired composition of amino acids in particular brain areas. It was demonstrated that higher level of pyridoxine in blood in elderly people promotes memory improvement.
Relieving symptoms of PMS
Some scientific studies demonstrated that vitamin B6 can be beneficial in case of premenstrual syndrome (PMS). The vitamin can reduce such symptoms as irritation, mood swings, anxiety and bloating.
Efficient immune system
Vitamin B6 determines the proper functioning of the immune system. It is involved in production of antibodies, lymphocytes and IL-2. Moreover, many key enzymatic reactions depend on the presence of the coenzymatic form of vitamin B6. Vitamin deficiencies weaken defence mechanisms of the body system and increases vulnerability to infections.
Support in case of pregnancy nausea
Vitamin B6 can relieve morning sickness associated with pregnancy (and not only). However, you should consult your doctor.
To sum it all up, P5P PLUS is a dietary supplement of wide spectrum of applications. Basic indications for use are deficiencies of vitamin B6.
Moreover, it improves circulatory system and immunity as well as can be useful in case of PMS and pregnancy nausea. Benefits from preparation use in case of cognitive skills improvements make it usefuls for pupils, students and white collar workers as well as for people with depression and sleeping disorders.
It is assumed that optimal dose of vitamin B6 for an adult amounts for 50–100 mg (1–2 capsules), maximally 3 times a day. To achieve the expected effects, it is worth to start the supplementation with the smallest dose (1 capsule a day) and then gradually increase it. You should remember that prolonged use of big doses (more than 200 mg) can result in neuropathy and pyridoxine addiction, which is why it is recommended to take breaks.
Demand for vitamin B6 is determined by the amounts of consumed protein. It is assumed that people on high-protein diets have increased demand for vitamin B6.
Vitamin B6 can be helpful in case of morning sickness associated with pregnancy. The recommended dose amounts for 50 mg a day. Before starting the supplementation, both pregnant and breast feeding women should consult a doctor.
Apollo’s Hegemony is a manufacturer of dietary supplements whose composition is based on the latest scientific research and experience. The company is constantly expanding its range of products and taking care that they are of top quality.
It offers formulations which have multiple effects on the body and those with more targeted effects – e.g. boosting alertness and focus, increasing the tolerance to stress, promoting peaceful sleep and maintaining the health of the liver and adrenal glands.
Dietary supplements by Apollo’s Hegemony are effective owing to carefully selected composition which comprises the most potent forms and their precise doses. What is more, herbal supplements contain standardised extracts.
All products of this brand comply with good manufacturing practices (GMP) and their ingredients are vegan and vegetarian friendly.
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Microcrystalline cellulose, rice flour, capsule shell.
The product has not been tested for substances banned by the World Anti-Doping Agency (WADA).
Vitamin B6 (pyridoxine, pyridoxal, pyridoxamine) is soluble in the liquid. It participates in the metabolism of proteins, fats and carbohydrates. By reducing the amount of fat in the blood do not enable deposition of the body. It helps the absorption of magnesium and vitamin B12 (cobalamin). It works on the muscle antispasmodic and anti-inflammatory pain in the joints. It acts anti. It provides efficient operation of the brain. It increases energy increasing vigor of a man. The demand for vitamin B6 increases during pregnancy and breast-feeding infants. The natural product is: yeast, eggs, wheat germ, meat (liver), wheat bran, nuts, peanuts peanuts, soybeans. There is a hypothesis that can be synthesized by intestinal bacteria.
Deficiency of vitamin B6 causes abnormal metabolism of proteins, decrease in lymphocytes in the blood, causes a feeling of lethargy and fatigue intensifies.
Dosage: 1.5-2.5 mg daily (increased demand during pregnancy and lactation).
Magnesium (element from the group of alkaline earth metals, atomic no. 12, a chemical symbol - Mg), one of the most important health microelements, participates in the synthesis process of the disintegration of high energy compounds and processes of transformation of hydrocarbons and fats. It affects the dilation of blood vessels and lower blood pressure, prevents hypercoagulable state. Shortages affect cardiac arrhythmias, malignant muscle cramps, insomnia and anxiety. It is a component of many dietary supplements and found in foods such as whole grain bread, legumes, buckwheat, rice, fish, meat, as well as chocolate, cocoa and nuts.
Dosage of 100 - 500 mg / day
Magnesium malate - a form of magnesium which is well-absorbed in the human organism, from which we may derive additional benefits thanks to the presence of malic acid residue. It is engaged in the transformations aiming at energy extraction in the organism, thanks to which supplementation with malate may positively influence energy metabolism.
Another advantage of magnesium malate distinguishing this form among other numerous forms of this element is its ability to bind and neutralize toxic heavy metals. It may be an antidote for their aggregation in the organism, demonstrating neuroprotective effect.
Taking care of the proper magnesium supply is important due to the health of the cardiovascular system. Its insufficient amounts in diet may cause the increase of pressure and disorders of the rhythm of the heart work. Researchers indicate the correlation between magnesium deficiencies and increased risk of heart attack. Because of the health of the circulatory system, the positive influence of magnesium on lipid profile is also important.
Moreover, magnesium is an important element to maintain optimal sugar metabolism. Benefits from its supplementation will be also noticed by people dealing with diabetes, as it was proven that it may limit the development of diabetic polyneuropathy.
Proper supply of magnesium is important also due to the endurance of bone tissue in the organism. Magnesium belongs to the group of elements that build and strengthen the structure of bones.
When talking about magnesium activity, we must not forget about its positive influence on the functions of the nervous system. It is conducive to proper nervous transmission and neuromotor coordination.
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