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Hi-Tech Caralluma is a dietary supplement with an extract from Caralluma – an exotic plant with a wide range of uses in folk medicine. Nonetheless, it is used commonly to curb the appetite.
Caralluma fimbriata is a plant with a range of substances which may help treat different diseases. However, the most important ones are pregnane glycosides which reduces cravings for snacking between meals and promotes body fat loss by having a central and peripheral effect.
Origin and general effects
Caralluma is a plant growing commonly in India. It is used in traditional medicine to treat different diseases –– rheumatism, diabetes, leprosy and aother inflammatory diseases. Caralluma fimbriata, which is believed to curb the appetite, has become especially popular. Owing to its action, it is used in supplements which promotes weight loss.
Effects of this plant are due to particular chemical compounds accumulated in its tissues – many kinds of glycosides, luteolin, chromium and beta-sitosterol. However, the predominant ones are believed to be pregnane glycosides.
Central control of appetite
Hypothalamus is a part of the brain composed of nuclei (a cluster of grey matter), responsible for autonomic control of processes vital to normal functioning because it regulates the body’s temperature, thirst, hunger, fight-or-flight response, aggression and sexual behaviour.
The reception of signals for hunger and satiety depends mainly from the functioning of two clusters of neurons near the arcuate nucleus (orexigenic – related to hunger, secreting NPY and AgRP, as well as anorexigenic – associated with satiety, releasing POMC and CART). They are controlled both by substances produced both in the central nervous system (in its different parts) and peripheral nervous system.
Many “signals” of satiety are produced in the hypothalamus. In addition, they function also as hormones. This refers toα-MSH which is the result of post-translational cleavage of the peptide POMC. They include also some liberins (CHR and THR), somatostatin, vasopressin and oxytocin. Their receptor antagonist is BDNF.
Other parts of the brain are connected by endings of the vegus nerve with the digestive system and receive direct signals about the capacity of the stomach and digestive tract.
What is more, mediators, which regulate this balance, are secreted in the periphery. One of these is leptin, considered the “satiety hormone” because it is released from adipocytes and gastric cells and thus activates POMC/CART neurons, thereby reducing the appetite. Insulin, which is secreted by the pancreas, has a similar action. The same effect is in turn produced by, although via a slightly different mechanism, pancreatic polypeptide, peptide YY, GLP-1 and cholecystokinin, which acts also on the vagus nerve. Ghrelin has a antagonistic effect on these compounds – it triggers AgRP/NPY neurons and agonists of cannabinoid receptors located in the digestive tract, consequently stimulating the appetite.
Impact on appetite suppression
The regulation of the appetite in Caralluma supplementation is possible due to the content of pregnane glycosides. Studies suggest a triple mechanism of action. It has been observed that mRNA levels in the hypothalamus decreased for the peptide AgRP and increased for BDNF. This shows clearly that food intake is inhibited via the central nervous system. At the molecular level, glycosides helps increase the production of intracellular ATP which is a signal of normal energy homeostasis of the body. What is more, the emptying of the stomach is delayed which allows you to feel satiety for longer.
To sum up, Hi-Tech Caralluma is a supplement designed especially for individuals who want to reduce excess body fat. Caralluma extract will help them control better satiety and reduce hunger, resulting in a better mood and motivation, which are important factors for maintaining negative energy balance for longer.
The supplement is intended for persons who are willing to lose excess pounds in the form of body fat on a diet with caloric restriction. Without counting properly calories in your meals, this agent may not fulfill its function which is primarily to provide mental support for a person on a fat-reducing diet. Apart from taking this supplement, you should remember about consuming food with a high satiety index and rich in fibre. Unfortunately, its effects are not immediate and adaptation may last about a month. Because of that, do not discontinue supplementation after a few days.
The company Hi-Tech Pharmaceuticals was founded 1994 and it has grown to be a leader in the industry. It creates, manufactures and sells high-quality herbal products sold by the large, major retailers across the United States. The company has 45 supplements that develop muscle and strength, fat loss, sexual performance and healthcare. All products are aimed at improving life-quality and our supplements have unmatched in quality and efficacy. All their products are designed to improve the quality of life, and supplements are second to none in terms of quality and effectiveness. Hi-tech is a response to the needs of women and men, from active lifestyle to good sports condition. Hi-Tech Pharmaceuticals produces better products than the competition. Try it and you will not be disappointed.
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|per portion (1 capsule)||amount||%DV|
|Caralluma Fimbriata Extract 20:1||500 mg||**|
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