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Caralluma Caralluma

Hi-Tech Caralluma is a dietary supplement with an extract from Caralluma – an exotic plant with a wide range of uses in folk medicine. Nonetheless, it is used commonly to curb the appetite.

Caralluma fimbriata is a plant with a range of substances which may help treat different diseases. However, the most important ones are pregnane glycosides which reduces cravings for snacking between meals and promotes body fat loss by having a central and peripheral effect.

Origin and general effects
Caralluma is a plant growing commonly in India. It is used in traditional medicine to treat different diseases –– rheumatism, diabetes, leprosy and aother inflammatory diseases. Caralluma fimbriata, which is believed to curb the appetite, has become especially popular. Owing to its action, it is used in supplements which promotes weight loss.

Effects of this plant are due to particular chemical compounds accumulated in its tissues – many kinds of glycosides, luteolin, chromium and beta-sitosterol. However, the predominant ones are believed to be pregnane glycosides.

Central control of appetite
Hypothalamus is a part of the brain composed of nuclei (a cluster of grey matter), responsible for autonomic control of processes vital to normal functioning because it regulates the body’s temperature, thirst, hunger, fight-or-flight response, aggression and sexual behaviour.

The reception of signals for hunger and satiety depends mainly from the functioning of two clusters of neurons near the arcuate nucleus (orexigenic – related to hunger, secreting NPY and AgRP, as well as anorexigenic –  associated with satiety, releasing POMC and CART). They are controlled both by substances produced both in the central nervous system (in its different parts) and peripheral nervous system.

Many “signals” of satiety are produced in the hypothalamus. In addition, they function also as hormones. This refers toα-MSH which is the result of post-translational cleavage of the peptide POMC. They include also some liberins (CHR and THR), somatostatin, vasopressin and oxytocin. Their receptor antagonist is BDNF.

Other parts of the brain are connected by endings of the vegus nerve with the digestive system and receive direct signals about the capacity of the stomach and digestive tract.

What is more, mediators, which regulate this balance, are secreted in the periphery. One of these is leptin, considered the “satiety hormone” because it is released from adipocytes and gastric cells and thus activates POMC/CART neurons, thereby reducing the appetite. Insulin, which is secreted by the pancreas, has a similar action. The same effect is in turn produced by, although via a slightly different mechanism, pancreatic polypeptide, peptide YY, GLP-1 and cholecystokinin, which acts also on the vagus nerve. Ghrelin has a antagonistic effect on these compounds – it triggers AgRP/NPY neurons and agonists of cannabinoid receptors located in the digestive tract, consequently stimulating the appetite.

Impact on appetite suppression
The regulation of the appetite in Caralluma supplementation is possible due to the content of pregnane glycosides. Studies suggest a triple mechanism of action. It has been observed that mRNA levels in the hypothalamus decreased for the peptide AgRP and increased for BDNF. This shows clearly that food intake is inhibited via the central nervous system. At the molecular level, glycosides helps increase the production of intracellular ATP which is a signal of normal energy homeostasis of the body. What is more, the emptying of the stomach is delayed which allows you to feel satiety for longer.

To sum up, Hi-Tech Caralluma is a supplement designed especially for individuals who want to reduce excess body fat. Caralluma extract will help them control better satiety and reduce hunger, resulting in a better mood and motivation, which are important factors for maintaining negative energy balance for longer.

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Since 2005
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Caralluma Caralluma 60 caps.
Hi-tech
£ 21.78

Caralluma 60 caps.

features

Mass:
Endurance:
Fat loss:
Concentration:

- Delivery even day after tomorrow

- Foreign shippment from £ 4.48 Every £ 66.01 reduces shipping costs by £ 2.20

You have got questions about the product

sales@mz-store.co.uk

01709231594 (mon.-fri 900-1700)

- Delivery even day after tomorrow

- Foreign shippment from £ 4.48 Every £ 66.01 reduces shipping costs by £ 2.20

You have got questions about the product

sales@mz-store.co.uk

01709231594 (mon.-fri 900-1700)

Description
  • May facilitate the release of mediators that produce a feeling of satiety
  • Helps curb the appetite and cravings for food
  • May slow down the emptying of the stomach from gastric contents
  • Promotes body fat loss
  • Contains plant ingredients
  • Safe to use

Hi-Tech Caralluma is a dietary supplement with an extract from Caralluma – an exotic plant with a wide range of uses in folk medicine. Nonetheless, it is used commonly to curb the appetite.

Caralluma fimbriata is a plant with a range of substances which may help treat different diseases. However, the most important ones are pregnane glycosides which reduces cravings for snacking between meals and promotes body fat loss by having a central and peripheral effect.

Origin and general effects
Caralluma is a plant growing commonly in India. It is used in traditional medicine to treat different diseases –– rheumatism, diabetes, leprosy and aother inflammatory diseases. Caralluma fimbriata, which is believed to curb the appetite, has become especially popular. Owing to its action, it is used in supplements which promotes weight loss.

Effects of this plant are due to particular chemical compounds accumulated in its tissues – many kinds of glycosides, luteolin, chromium and beta-sitosterol. However, the predominant ones are believed to be pregnane glycosides.

Central control of appetite
Hypothalamus is a part of the brain composed of nuclei (a cluster of grey matter), responsible for autonomic control of processes vital to normal functioning because it regulates the body’s temperature, thirst, hunger, fight-or-flight response, aggression and sexual behaviour.

The reception of signals for hunger and satiety depends mainly from the functioning of two clusters of neurons near the arcuate nucleus (orexigenic – related to hunger, secreting NPY and AgRP, as well as anorexigenic –  associated with satiety, releasing POMC and CART). They are controlled both by substances produced both in the central nervous system (in its different parts) and peripheral nervous system.

Many “signals” of satiety are produced in the hypothalamus. In addition, they function also as hormones. This refers toα-MSH which is the result of post-translational cleavage of the peptide POMC. They include also some liberins (CHR and THR), somatostatin, vasopressin and oxytocin. Their receptor antagonist is BDNF.

Other parts of the brain are connected by endings of the vegus nerve with the digestive system and receive direct signals about the capacity of the stomach and digestive tract.

What is more, mediators, which regulate this balance, are secreted in the periphery. One of these is leptin, considered the “satiety hormone” because it is released from adipocytes and gastric cells and thus activates POMC/CART neurons, thereby reducing the appetite. Insulin, which is secreted by the pancreas, has a similar action. The same effect is in turn produced by, although via a slightly different mechanism, pancreatic polypeptide, peptide YY, GLP-1 and cholecystokinin, which acts also on the vagus nerve. Ghrelin has a antagonistic effect on these compounds – it triggers AgRP/NPY neurons and agonists of cannabinoid receptors located in the digestive tract, consequently stimulating the appetite.

Impact on appetite suppression
The regulation of the appetite in Caralluma supplementation is possible due to the content of pregnane glycosides. Studies suggest a triple mechanism of action. It has been observed that mRNA levels in the hypothalamus decreased for the peptide AgRP and increased for BDNF. This shows clearly that food intake is inhibited via the central nervous system. At the molecular level, glycosides helps increase the production of intracellular ATP which is a signal of normal energy homeostasis of the body. What is more, the emptying of the stomach is delayed which allows you to feel satiety for longer.

To sum up, Hi-Tech Caralluma is a supplement designed especially for individuals who want to reduce excess body fat. Caralluma extract will help them control better satiety and reduce hunger, resulting in a better mood and motivation, which are important factors for maintaining negative energy balance for longer.

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Composition

Composition

Container size: 60 capsulesServing size: 1 capsuleServings per container: 60
per portion (1 capsule)amount%DV
Caralluma Fimbriata Extract 20:1500 mg**

Other ingrednients

Gelatin, dicalcium phosphate, silica, FD&C Blue #1.

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