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Since 2005
Optimal Methylate Chewable 60 tab.Seeking Health |
30.78 €
|
 |
B6 P-5-P + Pyridoxine 60 caps. Labs212 |
12.74 € |
Seeking Health Optimal Methylate Chewable is a dietary supplement containing a complex of methylation supporting ingredients. Carefully selected, lower doses of individual substances allow gentle optimization of the methylation process, without overloading the system that could result in the phenomenon of "overmethylation" (also known as excess methyl groups, called "re-methylation").
Riboflavin conditions the activation of the MTHFR enzyme involved in folic acid metabolism.
Niacin is another MTHFR cofactor.
Vitamin B6 participates in the process of transsulfuration involving the transformation of harmful homocysteine into cysteine.
Folate and vitamin B12, by participating in the methylation process, regulate homocysteine metabolism and also support cell division.
Choline and betaine are involved in homocysteine remethylation with the help of the BHMT enzyme.
Magnesium is involved in the production of SAM – a substrate in methylation processes.
Zinc is a cofactor for the BHMT enzyme.
Molybdenum contributes to the maintenance of normal metabolism of sulfur amino acids, which may reduce the side effects of using methylation support supplements.
Pyrroloquinoline quinone reduces oxidative stress that may interfere with the methylation process.
Methylation in a nutshell
Methylation is an extremely important biochemical reaction that conditions the proper functioning of the body. It consists in transferring the methyl group to the appropriate molecule, which enables its activation. This process determines e.g., the proper gene expression, distribution of toxic homocysteine or transformation of vitamin B12 and folic acid into a bioavailable form.
Support in MTHFR gene mutations
Mutations in the MTHFR gene that encodes an enzyme necessary for the methylation process lead to its deficiency, which adversely affects the functioning of the body. There is a decrease in the levels of active forms of vitamin B12 and folate, which subsequently may lead to e.g. disorders of hematopoietic processes. The level of homocysteine also increases, and it predisposes to the occurrence of civilization diseases. To prevent these adverse effects, people with the MTHFR gene mutation should support the methylation process through appropriate supplementation.
To sum up, Seeking Health Optimal Methylate Chewable is a comprehensive preparation optimizing the methylation process. It is mainly addressed to people with the MTHFR gene mutation who are simultaneously hypersensitive to too high doses of methylation supporting substances found in many such supplements.
| per 1 tablet | amount | %DV* |
|---|---|---|
| Calories | 5 | |
| Total Carbohydrates | 1 g | < 1% |
| Riboflavin (50% as riboflavin and 50% as riboflavin 5'-phosphate sodium) | 2.5 mg | 192% |
| Niacin | 2.5 mg | 16% |
| Vitamin B6 (50% as pyridoxal 5'-phosphate and 50% as pyridoxine HCl ) | 2.5 mg | 147% |
| Folate [80% as Quatrefolic® (6S)-5-methyltetrahydrofolate, glucosamine salt and 20% as calcium folinate] | 170 mcg DFE (100 mcg) | 43% |
| Vitamin B12 (50% as methylcobalamin, 39% as hydroxocobalamin, and 11% as adenosylcobalamin) | 38 mcg | 1,583% |
| Choline (as choline bitartrate) | 25 mg | 5% |
| Magnesium (as magnesium citrate) | 25 mg | 6% |
| Zinc (as Zinc Bisglycinate Chelate) | 1.25 mg | 11% |
| Molybdenum (as Molybdenum Glycinate Chelate) | 12 mcg | 27% |
| Betaine Anhydrous (trimethylglycine) | 62.5 mg | ** |
| Pyrroloquinoline Quinone Disodium Salt | 1.5 mg | ** |
| *% DV (Daily Value) based on standard 2,000 calorie daily intake | ||
| **Daily Value not established |
Xylitol, natural flavors, ascorbyl palmitate, silica, stevia leaf extract, sea salt, monk fruit extract, citric acid, and malic acid.
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