Acetylcholine is one of the most important neurotransmitters used, among others, by these areas of the brain that are involved in the processes of long-term planning, concentration, motor skills education, effective learning skills.
An inrease of the level of this neuromediator improves memory functions, and the results of various tests of intelligence. However, the amount of this unique signal transmitter in the cholinergic system is limited by the enzyme called acetylcholinesterase (AChE), which destroys ACh to choline and acetic acid residue.
Substances preventing this phenomenon are called AChE inhibitors, which increase the level of acetylcholine, extend its activity time and increase a transduction in the cholinergic system. This category includes both natural substances (eg. huperzine A) and synthetic (eg. donepezil).
Galantamine is an allosteric agonist of nicotinic receptors and has been used as a nootropic