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- Increases the level of acetylcholine
- Better than galantamine and donepezil
- Improves cognitive functions
- Improves working memory
- Improves learning efficiency
- No side effects
- Natural plant extract
- Improves intellectual capabilities
- Stimulates the production of growth hormone
Huperzine A - an alkaloid which exhibits the capability of reversible inhibition of acetylcholinesterase (AChE), i.e. the enzyme responsible for the breakdown of one of the main neurotransmitters - acetylcholine. Therefore, it shows a similar effect to drugs which stimulate cholinergic transmission, used in the treatment of Alzheimer's disease and dementia symptoms. Those drugs are, e.g., galantamine, donepezil, rivastigmine or tacrine.
Huperzine as a potential nootropic
Currently, huperzine A is subject to clinical studies which have demonstrated that, compared with the above-listed substances, registered as AChE-inhibiting drugs, it crosses the blood-brain barrier more effectively, is more bioavailable and absorbable after oral administration, and its effect lasts longer and stays at a relatively constant level. Moreover, no symptoms of toxicity and adverse reactions have been observed.
In order to understand how beneficial huperzine supplementation is, the reader needs to know some facts about acetylcholine, whose level increases after taking the substance.
A mysterious and complex cholinergic system
Acetylcholine (ACh) is a chemical neurotransmitter which stimulates the parasympathetic nervous system; therefore, it is an antagonist of noradrenaline which stimulates the sympathetic nervous system. ACh’s synthesis takes place at the ends of cholinergic neurons as a result of attaching choline to the rest of acetic acid (acetyl radical),which occurs with choline acetyltransferase’s help, i.e. the enzyme which moves the acetyl group from acetyl-CoA to choline. The speed of the synthesis depends on choline concentration.
Acetylcholine molecules, freed from synaptic vesicles to a synaptic cleft as a result of exocytosis, link to a cholinergic receptor in a postsynaptic membrane and are afterwards very quickly broken down by the enzyme of specific cholinesterase (acetylcholinesterase - AChE) to choline and acetic acid. In that form, they are absorbed into blood vessels.
There are two types of cholinergic receptors - nicotinic (N) and muscarinic (M1, M2 - in the heart, M3, M4 - in glands, M5).
Nerve-muscle synapses and contractility of muscles
In every motor unit there is one nerve cell which is connected with muscle cells by its axon ending. The point of contact between the neuron's protrusions and a muscle cell is called a nerve-muscle synaptic terminal, and the tiny gap between the presynaptic and the folded postsynaptic membranes of a neuron is called a synaptic cleft.
No other than acetylcholine is the neurotransmitter which links with a receptor in the postsynaptic membrane of a nerve cell and which causes the muscle to contract. Raising its level is a common method applied in strength sports.
Acetylcholine in practice
That neurotransmitter has been gaining much attention and popularity. That is because it is responsible for proper communication between nerves and muscles and motor functions (which is particularly important for sportspeople, who have to reach maximum speed, reflex and coordination).
Back to huperzine
Clinical studies have shown a clear improvement in working (short-term) memory in people who take Huperzine A.
Short-term (working) memory is the one with a low capacity; it mediates in remembering information and recalling it from the long-term memory. Registered information is lost in the period of several seconds to several minutes; in that period, the received information is filtered through the mechanisms connected with concentration and through a comparison with information stored earlier in long-term memory.
Working memory is very important in everyday life. It is the basis for current thought connection, learning and communication - thanks to its activity, humans remember the beginning of an uttered sentence, whom they met in the street a while before, as well as they can delay some actions without the risk of forgetting what they were supposed to do. The memory's headquarters is a part of the cerebrum - the hippocampus.
By preventing the breakdown of acetylcholine, huperzine improves neurotransmission in the cholinergic system, thanks to which it improves memory, associating facts and concentration, as well as prevents Alzheimer's disease and dementia. That is because diseases like Alzheimer's are connected with the decrease of cholinergic abilities (that is the production of acetylcholine) in neurons. Moreover, by reducing the level of toxic glutamate and the activity of caspase-3, it protects the nervous system and prevents neuron apoptosis.
To sum up, Source Naturals Huperzine A is a dietary supplement recommended, above all, for people who need to increase their intellectual abilities and cognitive functions. Huperzine allows to learn and carry out everyday duties more efficiently.
|Product name:||Huperzine A 100mcg|
|Container size:||120 tablets|
|Serving size:||1 tablet|
|Servings per container:||120|
|Supplement facts:||per 1 tablet||amount||%DV|
|Huperzine A (Huperzia serrata leaf standardized extract)||100 mcg||-|
1 tablet 1 to 2 times daily.
Source Naturals is an American vitamin and herbal supplements provider created in year 1982 to support each individual’s potential to enjoy optimal health. The company subsequently introduced numerous of award-winning formulas, recognized for their excellence in independent surveys and nutritional analyses.
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